Search results for "D11"
showing 10 items of 337 documents
Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.
2010
Signal transducer and activator of transcription (STAT)-3 inhibitors play an important role in regulating immune responses. Galiellalactone (GL) is a fungal secondary metabolite known to interfere with the binding of phosphorylated signal transducer and activator of transcription (pSTAT)-3 as well of pSTAT-6 dimers to their target DNA in vitro. Intra nasal delivery of 50 μg GL into the lung of naive Balb/c mice induced FoxP3 expression locally and IL-10 production and IL-12p40 in RNA expression in the airways in vivo. In a murine model of allergic asthma, GL significantly suppressed the cardinal features of asthma, such as airway hyperresponsiveness, eosinophilia and mucus production, after…
Casa, corte y cancillería del obispo de Valencia Hug de Llupià (1398-1427)
1998
This survey is our modest contribution to the history of a medieval episcopal court. Its objective is to know the people who were the components of the Household, Court and Chancellery of the Valencia diocese Bishop, Hugo de Llupià (1408-1425), through the different posts, trades, servants and "familia" members who performed their duties at the service of the diocese episcopal management as well as at the Bishop himself. To do this study we have made use of five records belonging to the mentioned Bishop which are kept in the Diocesan Archives of Valencia coresponding to the years 1408, 1412, 1418, 1421 and 1425.[fr] Cette étude est une modeste contribution à l’hisioire d'une cour médiévale …
Un itinerario UNESCO in crescita. ‘Palermo arabo-normanna e le cattedrali di Cefalù e Monreale’, dal riconoscimento del 2015 al dibattito attuale
2021
ITALIANO: La World Heritage List riconosce in Sicilia sette siti, ultimo in ordine di tempo è l’itinerario ‘Palermo arabo-normanna e le cattedrali di Cefalù e Monreale’ (2015) che include dieci monumenti selezionati per le «condizioni d’integrità, autenticità e buono stato di conservazione». Nel 2018 la concomitanza delle manifestazioni ‘Palermo capitale della cultura’ e ‘Manifesta’ hanno contribuito ad ampliare il dibattito sulla consapevolezza e la valorizzazione del patrimonio, attraverso una visione urbana delle reti riconosciute. / ENGLISH: The World Heritage List includes seven Sicilian sites, the last in order of time to berecognized is the ‘Arab-Norman Palermo and the Cathedral Chur…
El señorío de la Vall de Perputxent (siglos XIII-XIV)
1986
Adhesive capsulitis in a patient affected by KBG Syndrome
2021
Background and Case presentation: KBG syndrome is a multiple congenital anomaly syndrome with variable presentation. Many physical anomalies also affect the orthopaedic field. We present a case of a young woman with diagnosis of KBG syndrome that is also affected by joint stiffness and adhesive capsulitis to the shoulders. Discussion: Many other cases have been reported to present joint stiffness and formation of keloids. Adhesive capsulitis is known to be related to autoimmune pathologies and endocrinological disorders. KBG syndrome is caused by heterozygous mutation in ANKRD11 gene and few patients with hypermobility of the joints have also been reported. Conclusions: The KBG syndrome mig…
Il «faticato peregrinaggio» di Isidoro Carini negli archivi e nelle biblioteche di Spagna (1881-1882)
2021
ITALIANO: Attraverso la Relazione di Isidoro Carini sulla missione negli archivi e nelle biblioteche spagnole nel 1881-1882 e dallo studio delle vicende della pubblicazione dei suoi risultati si ricostruisce l’avvio dell’utilizzazione delle fonti iberiche per la storia medievale siciliana e nazionale e il contesto della storiografia sulla Sicilia medievale alla fine dell’Ottocento. / ENGLISH: The Relazione by Isidoro Carini about his research mission in Spain (1881-1882) and the events of its publication allow to reconstruct the beginnings of both the use of Spanish sources for the Sicilian and Italian medieval history and the context of the Sicilian medieval historiography at the end of th…
Increased frequencies of CD11b+CD33+CD14+HLA-DRlowmyeloid-derived suppressor cells are an early event in melanoma patients
2014
Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population characterized by immunosuppressive activity. Elevated levels of MDSC in peripheral blood are found in inflammatory diseases as well as in malignant tumors where they are supposed to be major contributors to mechanisms of tumor-associated tolerance. We investigated the frequency and function of MDSC in peripheral blood of melanoma patients and observed an accumulation of CD11b(+) CD33(+) CD14(+) HLA-DR(low) MDSC in all stages of disease (I-IV), including early stage I patients. Disease progression and enhanced tumor burden did not result in a further increase in frequencies or change in phenotype of MDSC. By investig…
La Llegenda del cor menjat al Decameró de Boccaccio: Estratègies de traducció al català
2013
Resum: El grau d’intervencio del traductor determina l’acostament del text al lector. Amb la comparacio de les quatre traduccions catalanes de La llegenda del cor menjat , el conte nove de la quarta jornada del Decamero de Giovanni Boccaccio, es pot comprovar que cada traductor utilitza estrategies diferents per mirar de resoldre un mateix problema de traduccio. A mes del bagatge cultural i la subjectivitat de cada un d’ells, cal tenir en compte un seguit de factors (temporals, historics, referencials, lingu?istics, socials, etc.) que determinen el resultat final. Paraules clau: llegenda; cor; menjat; Decamero ; Boccaccio; estrategia de traduccio Abstract: The extent to which translators in…
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+T cells and successful immunotherapy against chronic viral liver infection
2013
Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intrahepatic myeloid-cell aggregates for T cell population expansion') without causing immunopathology. In the liver, CTL proliferation was restricted to iMATEs that were composed of inflammatory monocyte-derived CD11b(+) cells. Signaling via tumor-necrosis factor (TNF) caused iMATE formation that facilitated costimulation dependent on the receptor OX40 for expansion of the CTL popu…
Da poeta a poeta, da traduttore a traduttore: il carteggio tra Umberto Saba e Tomàs Garcés
2015
Riassunto: Il rapporto personale tra Umberto Saba e Tomàs Garcés cominciò agli inizi degli anni Trenta e si interruppe poco prima della guerra civile spagnola. Quest’articolo analizza ed edita per la prima volta tutte le lettere scritte da Saba al poeta catalano che sono state conservate presso l’archivio della famiglia Garcés. Parole chiave: poesia, traduzione, Umberto Saba, Tomàs Garcés Abstract: The personal relationship between Umberto Saba and Tomàs Garcés began in the early thirties and stopped just before the Spanish Civil War. This article analyses and edits for the first time all the letters written by Saba to the Catalan poet that have been preserved in the archives of f…