Search results for "D2"
showing 10 items of 2418 documents
A Multi-parameter Model for Effective Configuration of Supply Chains
2015
In this paper, a mathematical model for the strategic planning and design of supply chains in the globalization context is proposed. A multi-objective function is used to address decisions about capacity sizing, sourcing, and facility location, with the scope of maximizing supply chain profits. The model is dynamic and is applied to a multi-echelon, multi-facility and multi-product supply chain in hypotheses of delocalization. The model is characterized by the specific attention given to cost, revenue and financial factor modelling, which has been obtained by means of an activity-based approach and the inclusion of two drivers that are usually neglected in the literature: energy and labour…
La Llegenda del cor menjat al Decameró de Boccaccio: Estratègies de traducció al català
2013
Resum: El grau d’intervencio del traductor determina l’acostament del text al lector. Amb la comparacio de les quatre traduccions catalanes de La llegenda del cor menjat , el conte nove de la quarta jornada del Decamero de Giovanni Boccaccio, es pot comprovar que cada traductor utilitza estrategies diferents per mirar de resoldre un mateix problema de traduccio. A mes del bagatge cultural i la subjectivitat de cada un d’ells, cal tenir en compte un seguit de factors (temporals, historics, referencials, lingu?istics, socials, etc.) que determinen el resultat final. Paraules clau: llegenda; cor; menjat; Decamero ; Boccaccio; estrategia de traduccio Abstract: The extent to which translators in…
Binding abilities of a chiral calix[4]resorcinarene: a polarimetric investigation on a complex case of study
2017
Polarimetry was used to investigate the binding abilities of a chiral calix[4]resorcinarene derivative, bearing L-proline subunits, towards a set of suitably selected organic guests. The simultaneous formation of 1:1 and 2:1 host–guest inclusion complexes was observed in several cases, depending on both the charge status of the host and the structure of the guest. Thus, the use of the polarimetric method was thoroughly revisited, in order to keep into account the occurrence of multiple equilibria. Our data indicate that the stability of the host–guest complexes is affected by an interplay between Coulomb interactions, π–π interactions, desolvation effects and entropy-unfavorable conformatio…
The effect of detergents on the basement membrane complex of a biologic scaffold material
2013
The basement membrane complex (BMC) is a critical component of the extracellular matrix (ECM) that supports and facilitates the growth of cells. This study investigates four detergents commonly used in the process of tissue decellularization and their effect upon the BMC. The BMC of porcine urinary bladder was subjected to 3% Triton-X 100, 8 mM 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS), 4% sodium deoxycholate or 1% sodium dodecyl sulfate (SDS) for 24 h. The BMC structure for each treatment group was assessed by immunolabeling, scanning electron microscopy (SEM) and second harmonic generation (SHG) imaging of the fiber network. The composition was assessed by quantif…
Chlorophyll and Suspended Solids Estimation in Portuguese Reservoirs (Aguieira and Alqueva) from Sentinel-2 Imagery
2021
Reservoirs have been subject to anthropogenic stressors, becoming increasingly degraded. The evaluation of ecological potential in reservoirs is remarkably challenging, and consistent and regular monitoring using the traditional in situ methods defined in the WFD is often time- and money-consuming. Alternatively, remote sensing offers a low-cost, high frequency, and practical complement to these methods. This paper proposes a novel approach, using a C2RCC processor to analyze Sentinel-2 imagery data to retrieve information on water quality in two reservoirs of Portugal, Aguieira and Alqueva. We evaluate the temporal and spatial evolution of Chl a and total suspended solids (TSS), between 20…
Network design for surface water quality monitoring in a road construction project using Gamma Test theory
2021
Road construction has a negative environmental impact on the surrounding aquatic environment, requiring the continuous monitoring of surface water quality. Here, optimization of the water quality monitoring network (WQMN) is an essential step in supporting the sustainable development of road construction projects. This study introduces Gamma Test theory (GTT) as a practical method for optimizing the WQMN of surface waters during road construction. The water quality index (WQI) was computed in 48 monitoring stations for six monitoring periods from 2017 to 2019; data was acquired from a primary monitoring network over a new highway in southern Norway. Based on the results, it is possible to r…
The Peace Treaty of Fredrikshamn and its Aftermath in Sweden and Finland
2010
This article analyses the Peace Treaty of Fredrikshamn (Hamina in Finnish) and its consequences in Sweden and Finland. The Russians set strict preconditions for the commencement of peace negotiations with the Swedes in the summer of 1809. These conditions were realized almost <em>in toto</em> in the final peace treaty, which consisted of just twenty-one articles. In addition to regulations directly related to the ending of hostilities, the main provisions of the agreement entailed huge territorial losses for Sweden, strictly defining the regions it was to cede to Russia, the most important of which was Finland. Sweden was also enjoined to give up its alliance with Britain and to…
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epi…
2015
The development of selective anticancer vaccines that provide enhanced protection against tumor recurrence and metastasis has been the subject of intense research in the scientific community. The tumor-associated glycoprotein MUC1 represents a well-established target for cancer immunotherapy and has been used for the construction of various synthetic vaccine candidates. However, many of these vaccine prototypes suffer from an inherent low immunogenicity and are susceptible to rapid in vivo degradation. To overcome these drawbacks, novel fluorinated MUC1 glycopeptide-BSA/TTox conjugate vaccines have been prepared. Immunization of mice with the 4’F-TF-MUC1-TTox conjugate resulted in strong im…
T cell avidity determines the level of CTL activation
2004
To investigate the influence of avidity on T cell activation in vitro and in vivo, we analyzed T cells from St40 and St42 mice, which express the same transgenic TCR specific for an E1a-derived epitope of adenovirus type 5 with different expression levels and therefore different avidities. Splenocytes from both strains showed comparable cytolytic activities and required identical peptide concentrations for efficient target cell lysis and up-regulation of activation markers. However, the kinetics of CD25 up-regulation were strikingly different: whereas the majority of the high-avidity St42 T cells up-regulated the IL-2Ralpha chain within a few hours, low-avidity St40 T cells expressed only 5…
Definition of the HLA-A2 restricted peptides recognized by human CD8+ effector T cells by flow-assisted sorting of the CD8+ CD45RA+ CD28– T cell subp…
2003
SUMMARY In response to antigenic stimulation, naive MHC-class I restricted and antigen-specific CD8+ CD45RA+ CD28+ T cells undergo clonal expansion, differentiate into CD8+ CD45RO+ memory T cells and convert to CD8+ CD45RA+ CD28− T cells displaying potent immune effector functions upon re-encounter with the nominal antigen. We show that the effector CD8+ CD45RA+ CD28– T cell subset is expanded in peripheral blood lymphocytes (PBL) from patients with human papilloma virus (HPV)+ cervical lesions as well as in PBL from patients with pulmonary tuberculosis. Flow-cytometric cell sorted CD8+ CD45RA+ CD28– and CD8+ CD45RA+ CD28– T cells were tested for recognition of HLA-A2 restricted peptides de…