Search results for "DAMAGE"
showing 10 items of 1289 documents
Incipient damage identification through characteristics of the analytical signal response
2008
The analytical signal is a complex representation of a time domain signal: the real part is the time domain signal itself, while the imaginary part is its Hilbert transform. It has been observed that damage, even at a very low level, yields clearly detectable variations of analytical signal quantities such as phase and instantaneous frequency. This observation can represent a step toward a quick and effective tool to recognize the presence of incipient damage where other frequency-based techniques fail. In this paper a damage identification procedure based on an adimensional functional of the square of the difference between the characteristics of the analytical theoretical and measured sig…
Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays
2019
International audience; The human genome is replete with repetitive DNA sequences that can fold into thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular enzymes exist to cope with these structures whose stable accumulation would result in DNA damage through interference with DNA transactions such as transcription and replication. Therefore, the chemical stabilization of secondary DNA structures offers an attractive way to foster DNA transaction-associated damages to trigger cell death in proliferating cancer cells. While much emphasis has been recently given to DNA quadruplexes, we focused here on three-way DNA junctions (TWJ) and report on a strategy t…
Modelling unilateral damage effect in strongly anisotropic materials by the introduction of the loading mode in damage mechanics
1999
Abstract Damage weakens the mechanical characteristics of materials. But this weakening can disappear if the cracks close again: this is called the unilateral effect of damage. We propose a model of this phenomenon using damage mechanics in the case of a diffuse network of identical microcracks. The microcracks state is defined with two internal state variables. These two variables are control parameters of the geometry of the microcracks. They also define the loading mode in damage mechanics as in fracture mechanics. In order to limit the anisotropy induced by the microcracks, hence by the loading, we suppose that the geometry of damage spreads into preferential directions. Therefore, this…
Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)2]: study of its interaction with DNA and hydrogen peroxide
2001
A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; α=112.05(2), β=93.92(2), γ=108.30(2)° and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N s u l f o n a m i d a t e and N q u i n o l i n e atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.
Finite fracture mechanics analysis of crack onset at a stress concentration in a UD glass/epoxy composite in off-axis tension
2010
The presence of stress concentrations at holes and notches is known to reduce the strength of composite materials. Due to complexity of the damage processes at a stress raiser in a composite, different modeling approaches have been developed, ranging from empirical point and average stress criteria to involved damage mechanics or cohesive zone-based models of failure. Finite fracture mechanics approach with a coupled stress and energy failure criterion, recently developed and applied mainly to cracking in homogeneous isotropic materials, allows predicting the appearance and propagation of a crack using material strength and toughness characteristics obtained from independent tests. The pres…
Piezospectroscopic study of mechanical stress in Al2O3:Cr under swift heavy ion irradiation
2009
Abstract The spatial distribution of mechanical stresses in Al2O3:Cr single crystal irradiated with (1 ÷ 3) MeV/amu Kr, Xe and Bi ions has been studied by using laser confocal scanning microscopy technique. The stress level as a function of the ion penetration depth has been evaluated from depth-resolved photostimulated R-line luminescence spectra exploiting the piezospectroscopic method. As it was found, the stress field generated by swift heavy ion irradiation is composed of stresses with maximal magnitude comparable with the ultimate stress limit of ruby crystals. Experimental data are discussed in the framework of a model considering the Cr3+ atoms as individual piezosensors.
Nonlocal Elastic-Damage Interface Mechanical Model
2007
The paper presents a nonlocal extension of the elastic-damage interface mechanical model, which is able to describe the effects of the spatially extended microstructure on the decohesion (or fracture) process along a surface. The key feature of the proposed model is an integral constitutive relation between tractions and displacement jumps at the interface. The presence of an integral kernel brings in the model an internal length measure, which characterizes the transition from the microscale, dominated by heterogeneities and discontinuous media, to the mesoscale, characterized as an enhanced homogenized continuum with nonlocal features. The motivations and the fields of applications of the…
Systematic comparison of Artificial Neural Networks for a SHM procedure applied to Composite Structure
2014
The problems related to damage detection represents a primary concern, particularly in the framework of composite structure. In fact, for this kind of structures barely visible damage can occur. Moreover, one of the major in-service damage of composite aircraft strcutures is represented by disbonds between the stiffeners and the skin undergoing dynamic or post-buckling loads. The effective implementation of a SHM system relies on the synthesis of non-destructive technique (NDT), fracture mechanics, sensors technology, data manipulation and signal processing, and it can receive a great improvement through the use of an Artificial Neural Networks. Different architectures of Artificial Neural …
Solving the Problems of Inspection Planning under Parametric Uncertainty of Underlying Models
2013
Certain fatigued structures must be inspected in order to detect fatigue damages that would otherwise not be apparent. A technique for obtaining optimal inspection strategies is proposed for situations where it is difficult to quantify the costs associated with inspections and undetected failure. For fatigued structures for which failures (fatigue damages) are only detected at the time of inspection, it is important to be able to determine the optimal times of inspection. Fewer inspections will lead to lower fatigue reliability of the structure upon demand, and frequent inspection will lead to higher cost. When there is a fatigue reliability requirement, the problem is usually to develop an…
Assessment of Modelling Structure and Data Availability Influence on Urban Flood Damage Modelling Uncertainty
2014
Abstract In modelling application, different model structures may be equally reliable in terms of calibration ability but they may produce different uncertainty levels; moreover, available data during model calibration may influence the uncertainty linked to the predictions of the same modelling structure. In the present paper, Bayesian model-averaging was applied to several flood damage estimation models in order to identify the best model combination for urban flooding distribution analysis in Palermo city center (Italy). During the analysis, was taken into account the effect of the available data growth on the model uncertainty with respect to the different combination of models outputs.