Search results for "DAS"
showing 10 items of 4164 documents
Inkjet printing methodologies for drug screening
2010
We show for the first time a contactless, low-cost, and rapid drug screening methodology by employing inkjet printing for molecular dispensing in a microarray format. Picoliter drops containing a model substrate (D-glucose)/ inhibitor (D-glucal) couple were accurately dispensed on a single layer consisting of the enzymatic target (glucose oxidase) covalently linked to a functionalized silicon oxide support. A simple colorimetric detection method allowed one to prove the screening capability of the microarray with the possibility to assay with high reproducibility at the single spot level. Measurements of the optical signal as a function of concentration and of time verified the occurrence a…
Injectable in situ forming microgels of hyaluronic acid-g-polylactic acid for methylprednisolone release
2013
Abstract A hydrophobic derivative of hyaluronic acid (HA), obtained by grafting polylactic acid (PLA) to the polysaccharide, has been exploited to produce injectable in situ forming microgels. First of all, self assembling properties of HA-g-PLA copolymer have been evaluated by determining the critical aggregation concentration (CAC) value, then this copolymer has been dissolved in a mixture water/NMP 5:2 v/v with a concentration greater than CAC. When solutions at 1% or 2% w/v were injected into Dulbecco phosphate buffer solution (DPBS) pH 7.4, microgels promptly are formed. Their stability in DPBS pH 7.4 in the absence or in the presence of hyaluronidase and cell compatibility have been e…
Oral manifestations in drug users : a review
2020
Background: In the dental environment there is not much talk about the oral manifestations resulting from the use of drugs, because in general the issue of drugs is a very difficult subject to deal with. Therefore, the objective of this work is to understand what are the most obvious manifestations in the oral cavity and as the dentist can detect them. Material and Methods: In order to carry out this bibliographical review, a scientific article search was made by consulting the PubMed database. The abstracts were read to recruit only what was consistent with the chosen topic. Results: The 23 sources of information affirmed the relationship between a bad state of general health, and more in …
Interferon-alpha 2a increases serum concentration of hyaluronic acid and type III procollagen aminoterminal propeptide in patients with chronic hepat…
1994
Interferon-alpha (IFN-alpha) has become an important drug for the treatment of chronic viral liver diseases. However, the action of IFN-alpha remains unclear. We investigated whether human recombinant IFN-alpha modulates serum concentrations of hyaluronic acid (HA) and type III procollagen aminoterminal propeptide (P-III-NP) in 56 patients with chronic hepatitis-B under IFN-alpha therapy. IFN-alpha increased the HA serum level in 44 of 46 patients and, after cessation of treatment, HA serum levels returned to the pretherapy levels. The increase of HA serum level was higher in patients with active cirrhosis (aC) than in patients with chronic persistent hepatitis (CPH) and in patients with se…
Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells
2012
PLoS one 7(7), e40853 (2012). doi:10.1371/journal.pone.0040853
Valoda: nozīme un forma. Plašsaziņas līdzekļu valoda
2009
Šajā krājumā apkopotās publikācijas veidotas uz referātu pamata, kas nolasīti Latvijas Universitātes Filoloģijas un mākslas zinātņu fakultātē notikušajos semināros “Funkcionālie stili un runas žanri plašsaziņas līdzekļos” 2007. un 2008. gadā. Krājumā ietverti gan zinātniski, gan populārzinātniski raksti, kas adresēti plašam interesentu lokam. Sākumā aplūkoti vispārīgi jautājumi par publicistikas valodas vietu latviešu valodas funkcionālo paveidu sistēmā, pēc tam analizētas leksikas lietojuma īpatnības un daži plašsaziņas līdzekļu valodas gramatiskie aspekti, krājuma beigu daļā vairāki reklāmas un sludinājumu valodai veltīti raksti, kā arī pētījumi par lietišķā stila izmantojumu plašsaziņas …
Atención a mujeres inmigrantes en un programa de mediación intercultural en salud
2014
Fundamentos: la mediación intercultural es una estrategia para una atención sanitaria de calidad orientada a la disminución de desigualdades en población inmigrante. El objetivo fue analizar los principales motivos de consulta con el servicio de mediación, el perfil de las mujeres atendidas y las características de la intervención realizada. Métodos: Estudio transversal de 339 episodios de atención de dos mediadoras interculturales (MI) desde febrero de 2008 a octubre de 2011 en Valencia. Se analizaron las variables de los registros individuales de las consultas de mediación: motivos de derivación a MI y profesionales que remitieron, motivos y problemas detectados por MI, tipo de intervenci…
A peptide inhibiting the collagen binding function of integrin alpha2I domain.
1999
Integrin alpha2 subunit forms in the complex with the beta1 subunit a cell surface receptor binding extracellular matrix molecules, such as collagens and laminin-1. It is a receptor for echovirus-1, as well. Ligands are recognized by the special "inserted" domain (I domain) in the integrin alpha2 subunit. Venom from a pit viper, Bothrops jararaca, has been shown to inhibit the interaction of platelet alpha2beta1 integrin with collagen because of the action of a disintegrin/metalloproteinase named jararhagin. The finding that crude B. jararaca venom could prevent the binding of human recombinant ralpha2I domain to type I collagen led us to study jararhagin further. Synthetic peptides represe…
Cambios en la activación electromiográfica de la musculatura de codo en sujetos sanos comparada con la activación muscular en sujetos con tendinopatí…
2021
La tendinopatía es uno de los problemas de tendón más frecuente de lesión en la actualidad. En el caso de miembros superiores, la alteración en los tendones es bastante significativa tanto en deportistas como en personas que no practican deporte. Sin embargo, hay pocos estudios que reflejen cómo repercute esto en las personas que lo padecen. Objetivos: el objetivo de este estudio es examinar y comparar la actividad electromiografia, la fuerza y la calidad de vida en personas con alteración tendinosa epicondílea del músculo extensor corto de carpo entre personas sanas, además de comprobar el efecto de la punción seca como rama de tratamiento en la actividad muscular, fuerza y dolor. Material…
Profesionālās sporta leksiskas attīstība augstskolā
2016
Profesionālā leksika ir vissvarīgākais aspekts jebkuram speciālistam kādā noteiktā sfērā, īpaši profesionāliem, augsta līmeņa sportistiem, kuri ceļo un komunicē ar cilvēkiem no visas pasaules. Šī maģistra darba mērķis ir izpētīt sporta studentu profesionālās leksikas attīstības veidus ar komunikatīvo stratēģiju pielietojumu. Gadījuma izpēte ir izvēlēta kā pētījuma metode un tādi datu iegūšanas instrumenti kā aptaujas, novērošanas, intervijas un izmēģinājuma mācīšana atklāja, ka studenti ir ļoti atsaucīgi, lietojot komunikatīvo mācīšanas pieeju. Profesionālās leksikas attīstība ir visefektīvākā, ja tiek izmantoti komunikatīvi uzdevumi, kuri līdzinās reālām dzīves situācijām. Autentisku mater…