Search results for "DCA"

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons

2020

Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo

Constructing knowledge : epistemic practices in three television interview genres

2011

This study analyses epistemic practices in broadcast television interviews, focusing on three different interview genres: celebrity interviews, sports interviews and political interviews. In the analysis I examine the linguistic and interactional practices that are used to construct knowledge in the interviews. These practices include mobilization of different types of knowledge, use of assessments to invite first-hand knowledge, negotiation of epistemic stances while disaligning with the question, and use of assessments for claiming or contesting epistemic rights to authority and expertise. The study comprises four articles and a summary. Article I focuses on celebrity interviews and analy…

More Relevant Today Than Ever: Past, Present and Future of Media Performance Research

2020

Media performance is constitutive for functioning democracies. But what is the situation regarding media performance in the age of digitalisation? And how can media performance continue to be assured under the current difficult economic conditions for the news industry? In this essay, we give a short overview of how media performance research has developed from the introduction of private broadcasting to the spread of the Internet and social media. In the course of this development, the initial focus of media performance research on media content has broadened to include media quality from the user perspective. We show how the contributions to this thematic issue relate with existing lines …

Supporting student teachers’ reflection through assessment : The case of reflective podcasts

2023

Reflection is a key learning objective of teacher education, yet little is known about the ways in which it could be supported through assessment. In this case study (N = 14), we examine the potential of a novel assessment task—reflective podcasting—in supporting first-year student teachers’ reflection. We analyzed student group podcasts and corresponding student reflections and found that the task engendered reflection. Three theory-driven dimensions were constructed to emphasize the unique nature of podcasts for student reflection: experientiality, authenticity, and communality. We encourage factoring these dimensions into assessment designs that seek to foster student reflection. peerRev…

A Comparison of Physical Activity Levels in Childcare Contexts among Finnish and Dutch 3-Year-Olds

2016

The aim of the current study was to determine Finnish and Dutch three-year-old preschool children’s physical activity (PA) levels and how levels vary across gender, location, time of day and social contexts in both countries. A modified version of the Observational System for Recording Physical Activity in Children-Preschool (OSRAC-P) was used to measure children’s PA levels and contextual variables (e.g. group composition, prompts) of children attending childcare centres in Finland and the Netherlands. In total, 90 Finnish children (46 boys and 44 girls) and 97 Dutch children (46 boys and 51 girls) were observed. Three-level linear regression analyses with cross level interactions were use…

Profil współczesnej opiekunki małych dzieci

2017

Ostatnie lata przynoszą duże zainteresowanie problematyką pozarodzinnej opieki nad małym dzieckiem. Poszukując najlepszych rozwiązań w tym zakresie nie sposób pominąć instytucji opiekunki dziecięcej, która od wielu lat na trwale wpisuje się w ów system. W publikacji podjęto temat niani, zarówno w płaszczyźnie teoretycznej, z uwzględnieniem rysu historycznego a także uregulowań prawnych, jak i badawczego - przeanalizowano 98 ofert, które w ostatnich dwóch latach pojawiły się na portalu internetowym www.niania/pl/opiekunka/opole. Ich analiza pozwoliła nakreślić profil rozwojowy współczesnej opiekunki małych dzieci jako osoby młodej, wykształconej, z pewnym doświadczeniem zawodowym, gotową wyk…

Family and work-related risk factors in children's social–emotional well-being and parent–educator cooperation in flexibly scheduled early childhood …

2023

Non-standard work schedules (NSWS) have become typical, but their associations with childcare arrangements and children's well-being are unknown. This study explores how risk factors are associated with the social–emotional well-being of girls and boys using flexibly scheduled early childhood education and care. Furthermore, the study investigates whether well-functioning cooperation between parents and educators buffers the negative effects of the risk factors. This study, which is a part of a larger survey carried out in three European countries, reports Finnish parents' (N = 146) perspectives. The results showed that high parental stress was associated with low child well-being. Strong p…

Socioecological correlates of perceived motor competence in 5- to 7-year-old Finnish children

2019

We investigated child, family, and environmental factors associated with young children’s perceptions of locomotor (LM) and object control (OC) skills. The participants comprised 472 children (6.22 ± 0.63) and their parents. The children were assessed for their perception of motor competence in LM and OC skills (using the pictorial scale of Perceived Movement Skill Competence for young children), and actual motor competence (Test of Gross Motor Development 3rd edition and Körperkoordinationstest Für Kinder). Anthropometrics were calculated using the children’s body mass index standard deviation scores. A parent questionnaire included questions about child factors (sex, child’s independent w…

Unmixing methods in novel applications of spectral imaging

2014

Opiskelijoiden podcastit ja vlogit kielenoppimisen ja arvioinnin tukena

2020

Tieto- ja viestintäteknologia tarjoaa monia mahdollisuuksia kielen oppimiseen, opettamiseen ja arviointiin. Podcastit ja vlogit ovat monille opiskelijoille vapaa-ajalta tuttuja, mutta yliopisto-opetuksessa niitä on toistaiseksi käytetty vain rajallisesti. Tässä artikkelissa esittelen opetuskokeilujani, joissa olen hyödyntänyt opiskelijoiden tekemiä vlogeja ja podcasteja osana pohjoismaisten kielten kursseja. Onnistuneet kokeilut ja positiivinen opiskelijapalaute innostavat jatkamaan vlogien ja podcastien käyttöä opetuksessa ja arvioinnissa myös jatkossa. nonPeerReviewed