Search results for "DELE"

Smart Planning and Intelligent Cities: A New Cambrian Explosion

2014

We live in the society of knowledge, creativity and innovation: true anti-cyclical factors with respect to the crisis that has overrun the traditional development protocols and that requires powerful processes of creation and spread of knowledge. The true innovation has no boundaries, it has to affect each aspect of institutions and enterprises and operates as a mutagen of society, requiring a paradigm shift. Startups, fablabs, co-workers, makers and smart citizens have given rise to a global urban movement and most cities now have a sizeable colony: a true smart ecosystem for improving social innovation. Between them they are home to hundreds of accelerators and thousands of smart places a…

TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

2013

Signalling by the cytokine TGF-β regulates mature CD4+ T cell populations but is not involved in the survival and function of regulatory T cells.

1p36 deletion results in a decrease in glycosaminoglycans which is associated with aggressiveness in neuroblastic tumors

2018

Despite our deep understanding of neuroblastic tumors, some patients still suffer treatment failure, so pre-treatment risk stratification still requires improvement and the search for new therapeutic targets must continue. Here we correlated prognostic clinical and biological features of neuroblastic tumors with the density of extracellular matrix glycosaminoglycans (the main components of the extracellular matrix ‘ground substance’), in nearly 400 primary samples. We also studied the relationship between the density of extracellular matrix glycosaminoglycans and the expression of B3GALT6, an enzyme required for their synthesis. We associated a decrease in glycosaminoglycans with neuroblast…

Aukslēju mandeļu kriptolīzes vēlīnu rezultātu novērtēšana

2019

Darba aktualitāte: Aukslēju mandeļukriptolīze ir salīdzinoši jauna ārstēšanas pieeja otorinolaringoloģijas jomā. Pirmie pētījumu ziņojumi meklējami vien 1994.gadā. Kopš tā laika arvien nav atrasti objektīvi, reāli diagnosticējami pacientu atlases kritēriji, kuriem šī ārstēšanas metode varētu sniegt labākos rezultātus ilgtermiņā. Šobrīd biežākais šīs procedūras veikšanas iemesls ir hronisks kazeozs tonsilīts (CCT), ko pavada tādi simptomi kā bāli dzeltenīgu, biezpienam līdzīgu graudiņu jeb t.s. detrīra korķu veidošanās, halitoze (slikta elpa, “foetor ex ore”), nepatīkama piegaršā mutē, pastāvīga diskomforta vai niezēšanas sajūtas rīklē, kā arī svešķermeņa sajūta rīklē. Lai arī šis patoloģisk…

11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction

2012

In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-induced pulmonary vasoconstriction. Since pulmonary artery smooth muscle cells also express BK channels, we assessed the consequences of BKβ(1) subunit deletion on pulmonary responsiveness to 11,12-EET as well as to acute hypoxia. In buffer-perfused mouse lungs, hypoxia increased pulmonary artery pressure and this was significantly enhanced in the presence of NO synthase (NOS) and cyclooxygenase (…

Array CGH defined interstitial deletion on chromosome 14: a new case

2009

Interstitial deletions of the long arm of chromosome 14 are relatively rare. We report a 8.5-year-old girl with dysmorphic facial features and mental retardation associated with a de novo interstitial deletion of chromosome 14. The comparison between our patient and all published patients is reviewed. The genetic investigations have allowed us to define the critical chromosomal region and to start an accurate follow-up.

Biopolitik und Zoopolitik

2014

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

2007

AbstractIntegrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines derived from patients with different B-NHLs delineated 20 homozygous deletions at 7 chromosome areas, all of which contained tumor suppressor gene targets. Further investigation revealed that only a fraction of primary biopsies presented inactivation of these genes by point mutation or intragenic deletion, but instead some of them w…

Supervision by the state prerogatives of french sports federations

2013

French sports federations have developed without any state intervention. They had their own prerogatives to organize competitions in their respective sporting discipline. By virtue of their association status, they were entirely governed by private law. However, following a decision taken in 1974 by the Board of State confirming the existence of a public service delegated to the federal structure, the legislation gradually devote the principle of granting their prerogatives by the Ministry of Sports through two acts: the ministerial approval and delegation of public service. Since the issuance of these acts is synonymous powers recognized federations by state law and that the delegation lea…

Modélisation du bilan environnemental d'une culture de colza

1998

National audience