Search results for "DESIGN"
showing 10 items of 5885 documents
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…
il volto della morte: le maschere funerarie della sepoltura dei preti morti di Gangi
2014
riassunto — Le mummie moderne e il signifcato recondito della doppia sepoltura nelle culture mediterranee moderne sono da tempo ampiamente dibattuti. In questo lavoro si discute di una particolare “collezione” di corpi di ecclesiastici, mummifcati ed esposti in un comune montano madonita della Sicilia, Gangi. I corpi, principalmente risalenti al XIX secolo, mummifcati per colatura come nella tradizione del tempo e vestiti degli abiti talari, sono esposti nel piano sottostante della Chiesa Madre, in quella che nella tradizione è detta la “fossa dei parrini” (fossa dei preti). Le mummie, a differenza di altri siti siciliani e mediterranei, sono altresì corredate di sonetto commemorativo e di …
Joint Subcarrier and Phase Shifts Optimization for RIS-aided Localization-Communication System
2022
Joint localization and communication systems have drawn significant attention due to their high resource utilization. In this paper, we consider a reconfigurable intelligent surface (RIS)-aided simultaneously localization and communication system. We first determine the sum squared position error bound (SPEB) as the localization accuracy metric for the presented localization-communication system. Then, a joint RIS discrete phase shifts design and subcarrier assignment problem is formulated to minimize the SPEB while guaranteeing each user’s achievable data rate requirement. For the presented non-convex mixed-integer problem, we propose an iterative algorithm to obtain a suboptimal solution …
’Green’ strategies and approaches. A contribution from the off-site and upcycling of discarded shipping containers
2021
La Terra versa oggi in una condizione di vulnerabilità che gran parte degli studiosi attribuisce a un modello di crescita infinita inseguita su un pianeta con risorse limitate. In relazione a questo contesto ambientale critico il contributo si propone di stimolare nuove prassi per il settore delle costruzioni suggerendo una visione sistemica che faccia ricorso contemporaneamente a più approcci sostenibili e circolari e che, combinando tecniche e tecnologie tradizionali e innovative, consenta l’eliminazione di scarti e rifiuti. In particolare, l’articolo illustra le potenzialità della prefabbricazione nel contenimento degli impatti ambientali diretti e indiretti rispetto a un’equivalente cos…
Sustainable Hospital Architecture: Quality Principles for a Responsable Design
2006
The theme of sustainability in the hospital design is today a subject widely discussed in the architectural field. The functioning of the health facility, also under the point of view of physical and organizational consistency is one of the primary objectives of the national government. There is the urgency to answer adequately and responsibly for the needs of society, assuring physical and psychological comfort and putting the center of the design process the individual sanitary needs. The social transformations and the technological progress in sanitary field have considerably modified the hospital conception. The hospital becomes space in which the individual is revalued for him itself a…
Stormwater Source Control as a Strategy for Sustainable Development: State of the Practice and Perceived Trends
2005
The primary objective of the paper is to draw upon the experiences acquired in many parts of the world to provide an up-to-date summary of the state of the practice for source control techniques and approaches, in a sustainable development context. After a discussion of the prevailing context for urban drainage approaches, three main themes covering techniques and design criteria, institutional aspects and performance issues are discussed relative to source control implementation. The discussion is based on findings from the compilation and analysis of available literature, recently developed databases, the experience of the different members of the SOCOMA group and recent research on desig…
Onnistuminen muotoilussa : muotoilijan työn tavoitteiden mittaus ja arviointi
2016
Muotoilun arvoa on mitattu yleensä lopputulosta ja ulkoisia hyötyjä arvioiden. Se, miten muotoilija itse määrittelee työnsä tavoitteet, on jäänyt vähäisemmälle huomiolle. Tässä tutkielmassa esitetään mittauskehikko muotoilijoiden omalle työlleen asettamien tavoitteiden mittaamista, kuvailua, vertailua ja toimialan kehityksen seurantaa varten. Mitattavan ilmiön hypoteesi käsittää seitsemän ulottuvuutta: kolme ekologisen kestävyyden periaatetta ja yhden sosiaalisen kestävyyden periaatteen sekä loppukäyttäjän tarpeet, muotoilijan omat tarpeet ja ulkoiset vaatimukset. Tutkielman alussa kuvaillaan muotoilualaa ja sen muutoksia Suomessa sekä arvojen merkitystä muotoilijan työssä. Teorialuku jäsen…
MUV: A Game to Encourage Sustainable Mobility Habits
2019
This working paper investigates the question of changing people mobility towards more sustainable habits involving them in an engaging gameplay. The work is performed within MUV H2020 research and innovation action. The game design, definition and features have been co-created through the involvement of different citizens and stakeholders in six European neighbourhoods. The paper discusses the game design as resulting from co-creation and co-design experiences with each neighbourhood communities involved in initial phases. The paper argues that the local co-design activities have influenced the game definition, together with the community engagement approach. The MUV gameplay approach resul…
What Can You Achieve in Eight Years? : A Case Study on Participation, Effectiveness, and Overall Impact of a Comprehensive Workplace Health Promotion…
2019
Objective: To investigate participation and effectiveness of a multiyear comprehensive workplace health promotion (WHP) program. Methods: Participation and effectiveness data came from employer and vendor systems. Health data came from health risk assessments (HRA) and biometric screenings. Participation and effectiveness were analyzed using descriptive analyses, T-tests and Mann-Whitney U tests where appropriate. Overall impact was assessed using the PIPE Impact Metric. Results: 86% of employees completed the HRA and 80% the biometrical screenings. Annual participation rate was 24%, and total reach was 58%. The portion of successful participants was 23% in 2010–2013 and 18% in 2014–2017. P…
Parallel Genetic Solution for Multiobjective MDO
1997
Publisher Summary This chapter reviews a multiobjective, multidisciplinary design optimization of two-dimensional airfoil designs. The control points on leading and trailing edges remain fixed, and the y-coordinates of the other control points are allowed to change during the optimization process. The grid for the Euler solver depends continuously and smoothly on the design parameters. The number of nodes and elements in the mesh might vary according to design because the meshes for the Helmholtz solver are done using the local fitting. The computations are made on an IBM SP2 parallel computer using high-performance switch and the MPICH message-passing library. As gradients are not required…