Search results for "DHE"
showing 10 items of 1975 documents
Hyaluronic acid and alpha-elastin based hydrogel for three dimensional culture of vascular endothelial cells
2018
Abstract The aim of this work was to demonstrate that employing a copolymer of hyaluronic acid and α-elastin (HA-EDA-g-α-elastin) is possible to produce a scaffold able to support the adhesion and growth of human vascular endothelial cells (HUVEC) thanks to its ability to incorporate and control the diffusion of vascular endothelial growth factor (VEGF). HA-EDA-g-α-elastin was crosslinked with low molecular weight hyaluronic acid (HALMW) to obtain a hydrogel that gives rise to the formation of three dimensional sponge after the freeze drying process. The physicochemical features the obtained material along with its ability to act as a support for the three dimensional culture of endothelial…
Enhanced adhesion and in situ photothermal ablation of cancer cells in surface-functionalized electrospun microfiber scaffold with graphene oxide
2017
The physicochemical characteristics of a biomaterial surface highly affect the interaction with living cells. Recently, much attention has been focused on the adhesion properties of functional biomaterials toward cancer cells, since is expected to control metastatic spread of a tumor, which is related to good probability containing the progression of disease burden. Here, we designed an implantable poly(caprolactone)-based electrospun microfiber scaffold, henceforth PCLMF-GO, to simultaneously capture and kill cancer cells by tuning physicochemical features of the hybrid surface through nitrogen plasma activation and hetero-phase graphene oxide (GO) covalent functionalization. The surface i…
PLLA scaffolds with controlled architecture as potential microenvironment for in vitro tumor model
2019
Abstract The "microenvironment" where a tumor develops plays a fundamental role in determining its progression, the onset of metastasis and, eventually, its resistance to therapies. Tumor cells can be considered more or less invasive depending both on the nature of the cells and on the site where they are located. Commonly adopted laboratory culture protocols for the investigation of tumor cells take usually place on standard two-dimensional supports. However, such cultures do not allow for reproduction of the biophysical properties of the tumor’s microenvironment, thus causing the cells to lose most of their relevant characteristics. In this work MDA-MB 231 breast cancer cells were cultiva…
Focal Cortical Lesions Induce Bidirectional Changes in the Excitability of Fast Spiking and Non Fast Spiking Cortical Interneurons
2014
A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unknown whether specific interneuronal subpopulations contribute differentially to such pathological condition. In the present study we investigated functional alterations of inhibitory interneurons embedded in a hyperexcitable cortical circuit at the border of chronically induced focal lesions in mouse …
1985. La adhesión de España a la Comunidad Económica Europea.
2014
La adhesión de España a la Comunidad Económica Europea. El 12 de junio de 1985 España y Portugal se adhirieron a la Comunidad Económica Europea, CEE. El Acta de Adhesión de España a las Comunidades Europeas se firmó en Madrid, en el acto protocolario que tuvo lugar en el Salón de Columnas del Palacio Real, en presencia del rey de España, Juan Carlos I. Firmaron el Acta de Adhesión el presidente del Gobierno Felipe González Márquez, el ministro de Asuntos Exteriores Fernando Morán López y Manuel Marín González, secretario de Estado de Relaciones con las Comunidades Europeas. La entrada de España en la CEE suponía el fin del aislacionismo de España, abriendo lo que iba a ser la época de mayor…
Estudio de la quiescencia y activación de las células madre neurales adultas por uniones adherentes: papel de la N-cadherina.
2017
El descubrimiento de poblaciones de células madre en el cerebro adulto (NSCs) de los mamíferos ha cambiado nuestra visión del sistema nervioso, añadiendo el concepto de plasticidad celular al de plasticidad neural. El conocimiento detallado de los mecanismos que permiten a las NSCs mantenerse indiferenciadas, dividirse de manera asimétrica para auto-perpetuarse mientras generan progenie diferenciada, y activarse para proliferar contribuyendo así a la renovación de ciertas poblaciones de neuronas durante toda la vida se ha convertido en un campo de investigación en continuo avance. El desarrollo de técnicas que permiten la posibilidad de expandir las NSCs in vitro y de estudiarlas en su micr…
Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations
2007
Policy Forum. Competing interests: ER has received research grants from Daiichi, Bayer, and Theravance and has served as a consultant to Pfizer, Theravance, Bayer, Wyeth, Rosetta, and BiondVax. Summary Points Brucellosis remains the commonest anthropozoonosis worldwide, and its treatment remains complex, requiring protracted administration of more than one antibiotic. In November 2006, a consensus meeting aimed at reaching a common specialist statement on the treatment of brucellosis was held in Ioannina, Greece under the auspices of the International Society of Chemotherapy and the Institute of Continuing Medical Education of Ioannina. The author panel suggests that the optimal treatment o…
Historia e historigrafía de los diccionarios del español
2019
Este monográfico presenta diecinueve trabajos sobre lexicografía española bajo la perspectiva diacrónica en la lexicografía, la visión histórica y el la historiografía lingüística en el ámbito del español. Se muestra el avance continuo e imparable en el que los retos actuales de la lexicografía como disciplina lingüística -propiciados por el progreso de las nuevas tecnologías digitales, la Informática, la utilización de bases de datos y corpus, y el aumento y variedad de las fuentes empleadas para la ejemplificación de las voces, junto con las herramientas metodológicas que proporciona la Lingüística y la Filología- permiten ofrecer nuevas aportaciones sobre nuestra perspectiva histórica de…
International BEAT-PCD Consensus Statement for Infection Prevention and Control for Primary Ciliary Dyskinesia in collaboration with ERN-LUNG PCD Cor…
2021
Introduction In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, and concern over chronic airway infection and patient-to-patient transmission is considerable. So far, there has been no defined consensus on how to control infection across centres caring for patients with PCD. Within the BEAT-PCD network, COST Action and ERS CRC together with the ERN-Lung PCD core a first initiative has now been taken towards creating such a consensus statement. Methods A multidisciplinary international PCD expert panel was set up to create a consensus statement for infection prevention and control (IP&C) for PCD, covering …
Tras la 14 ª Conferencia Internacional sobre el SIDA, ¿Cuánto sufrimiento nos espera todavía?
2002
Se tratan de analizar los factores que pueden incrementar o disminuir el sufrimiento de las personas que, soportan o van a soportar las consecuencias emocionales de la infección porVIH y/o de la aplicación o carencia de los tratamientos antirretrovirales disponibles. Su objetivo es conseguir que todos aquellos que practican comportamientos de riesgo, que se infectan con el VIH, que se someten a un tratamiento o no tienen acceso al mismo, así como también sus familiares y los agentes de salud que los atienden, puedan hacer frente a estas realidades al menor coste emocional posible. El mejor camino que nos conduce hacia este objetivo es el counselling.