Search results for "DISCIPLINE"
showing 10 items of 2858 documents
Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor.
2022
A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed and synthesized to explore more potent natural product-derived antitumor agents. The structures of the target compounds were confirmed by FTIR, NMR, and HRMS. The in vitro antitumor activity was tested by standard methyl thiazolytetrazolium assay and showed that 4i, 4g, 4s, and 4m are the best compounds with IC50 values of 6.04 ± 0.62µM, 3.21 ± 0.67µM, 19.09 ± 0.49µM, and 18.68 ± 1.53µM, against Hela, MGC-803, MCF-7, and A549, respectively. The results of the preliminary action mechanism studies showed that compound 4i, the representative compound, could induce cell apoptosis in Hela cells in a dose-dep…
Longitudinal associations between teacher-child interactions and academic skills in elementary school
2017
This study examined the extent to which the quality of teacher-child interactions assessed in kindergarten (6-year-olds) is associated with children's reading and math development across the elementary school years. The sample consisted of 515 Finnish children (271 boys, 244 girls). Teacher-child interactions were observed in 49 kindergarten classrooms. The findings from the latent growth curve models showed that high-quality teacher–child interactions in kindergarten were positively associated with the initial levels of reading and math skills. Furthermore, the results indicated that high-quality teacher-child interactions in kindergarten were positively associated with children's academic…
The Case Study in Family Business : An Analysis of Current Research Practices and Recommendations
2016
In this study, we identified and analyzed 75 articles in the family business (FB) literature between 2000 and 2014 as to the case study design they adopted. We found that the positivistic case study approach is the FB disciplinary convention. The two alternative approaches of critical realism and interpretivism are used to a significantly lesser extent. We anticipate that in the future the positivistic approach will continue to be used widely. The other two approaches can be employed to a higher extent since their use is likely to contribute to a scientific pluralism in FB case study research.
Disrupted Spatial Organization of Cued Exogenous Attention Persists Into Adulthood in Developmental Dyslexia
2021
Purpose: Abnormal exogenous attention orienting and diffused spatial distribution of attention have been associated with reading impairment in children with developmental dyslexia. However, studies in adults have failed to replicate such relationships. The goal of the present study was to address this issue by assessing exogenous visual attention and its peripheral spatial distribution in adults with developmental dyslexia.Methods: We measured response times, accuracy and eye movements of 18 dyslexics and 19 typical readers in a cued discrimination paradigm, in which stimuli were presented at different peripheral eccentricities.Results: Results showed that adults with developmental dyslexia…
Farewell to Anarchy : The Myth of International Anarchy and Birth of Anarcophilia in International Relations
2018
This article scrutinizes the conceptual history of international anarchy. The argument purported here is that even though the idea of international anarchy is often seen as very central for the academic discipline of international relations, the concept is in fact not found from the forerunners or classics of the discipline. The assumption of international anarchy is commonly seen as a defining feature of a Realist school of international relations. Yet, the concept and especially its “Realist” implications are not to be found in the classics of Realism, from Thucydides, Machiavelli or Hobbes. The idea of “international anarchy” emerges quite tentatively during the First World War, in the w…
Dalla creazione individuale al sistema della reviviscenza
2015
Kostantin Sergej Alekseev Stanislavskij segna l'inizio della grande tradizione della regia del Novecento. Le sue regie emergono da un sistema di recitazione fondato sull'immedesimazione e sulla memoria emotiva. Ma nella tradizione ottocentesca del grande attore italiano si registra una recitazione che, benché potesse apparire generata da una creazione individuale, in realtà sottostava alle regole di una forma codificata di voci e gesti appositi, ossia quella della drammatica-metodo italiano.
Giuseppe Cocchiara, il fascismo e il razzismo
2021
In questo saggio viene ricostruito il rapporto tra Giuseppe Cocchiara e il fascismo. L’antropologo visse in pieno la sua formazione culturale all'interno del regime al quale aderì con convinzione e slancio, militando sempre nelle sue fazioni più radicali, condividendone fedelmente le scelte più tragiche come la guerra d’Etiopia, sottoscrivendo le leggi razziali, impegnandosi nella seconda guerra mondiale con le armi culturali dell’antisemitismo e della lotta senza tregua contro la democrazia. Così quando, come in un «mondo alla rovescia», sconfitto il fascismo sotto il peso di un’umiliante e sanguinosa disfatta, saranno proprio gli odiati inglesi a valorizzarne la statura intellettuale e la…
Regional studies and political science. The theory of the dual unity of Silesia
2021
This paper concerns the status of regional studies in political science research. Analysing the theory of the dual unity of Silesia presented by the Polish political scientist Józef Kokot, the author attempts to formulate theoretical criteria that make a region an object of interest for political scientists and regional studies, a subdiscipline of political science.
Affect self-regulation through music
2018
The present dissertation focused on musical affect regulation, i.e. on the use of music to self-regulate affective states such as emotions, moods, and energy levels. In publication I, relevant findings from previous research were extracted and the field’s conceptual clarity and precision was assessed. Besides identifying weaknesses in conceptualization and providing recommendations for future studies, publication I found that not all the elements of affect regulation through music have been equally explored by research. Given the gap observed on the study of musical mechanisms underlying affect regulation, publication II placed a special focus on this component and its association with regu…