Search results for "DMI"
showing 10 items of 7539 documents
Solidarity and transparency against the COVID ‐19 pandemic
2020
COVID 19 Vaccine for Adolescents. Concern about Myocarditis and Pericarditis
2021
The alarming onset of some cases of myocarditis and pericarditis following the administration of Pfizer–BioNTech and Moderna COVID-19 mRNA-based vaccines in adolescent males has recently been highlighted. All occurred after the second dose of the vaccine. Fortunately, none of patients were critically ill and each was discharged home. Owing to the possible link between these cases and vaccine administration, the US and European health regulators decided to continue to investigate the potential causal relationship between COVID-19 mRNA vaccines and myocarditis. In any case, none of the patients fulfilled the criteria for multi-system inflammatory syndrome or Kawasaki-like disease and there wa…
Chiral Serum Pharmacokinetics of 4-Fluoroamphetamine after Controlled Oral Administration
2021
Abstract Over the last two decades, misuse of 4-fluoroamphetamine (4-FA) became an emerging issue in many European countries. Stimulating effects last for 4–6 hours and can impact psychomotor performance. The metabolism of amphetamine-type stimulants is stereoselective and quantification of (R)- and (S)-enantiomers has been suggested for assessing time of use. To date, no data on enantioselective pharmacokinetics is available for 4-FA in serum samples. An enantioselective liquid chromatography−tandem mass spectrometry (LC–MS-MS) method was developed using a chiral Phenomenex® Lux 3 μm AMP column. Validation of the method showed satisfactory selectivity, sensitivity, linearity (0.5–250 ng/mL…
Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress
2019
The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit®
Buccal drug delivery: what's new and what does the future hold?
2014
The buccal mucosa is the stratified squamous epithelial tissue inside lining of the cheeks. It is a favorable site of drug absorption since the tissue is non-keratinized, relatively immobile and strongly supplied with blood by a dense capillary-vessel network; moreover, it is highly tolerant to allergens, resistant to potentially harmful agents and has a relatively low enzymatic activity. The tissue consents quick onset of effect, offers an easily accessible and generally well-accepted site for drug delivery, is a useful route of administration in patients in an unconscious state (e.g., when swallowing is impaired), and is suitable for retentive dosage forms of administration. Buccal mucosa…
COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN…
2016
Allantoin is traditionally employed in the treatment of skin ulcers and hypertrophic scars. In the present work, to improve its local deposition in the skin and deeper tissues, allantoin was incorporated in conventional liposomes and in new argan oil enriched liposomes. In both cases, obtained vesicles were unilamellar, as confirmed by cryo-TEM observation, but the addition of argan oil allowed a slight increase of the mean diameter (∼130nm versus ∼85nm). The formulations, especially those containing argan oil, favoured the allantoin accumulation in the skin, in particular in the dermis (∼8.7μg/cm(2)), and its permeation through the skin (∼33μg/cm(2)). The performances of vesicles as skin d…
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin
2017
Gellan nanohydrogel and phospholipid vesicles were combined to incorporate baicalin in new self-assembling core-shell gellan-transfersomes obtained by an easy, scalable method. The vesicles were small in size (~107 nm) and monodispersed (P.I. ≤ 0.24), forming a viscous system (~24 mPa/s) as compared to transfersomes (~1.6 mPa/s), as confirmed by rheological studies. Gellan was anchored to the bilayer domains through cholesterol, and the polymer chains were distributed onto the outer surface of the bilayer, thus forming a core-shell structure, as suggested by SAXS analyses. The optimal carrier ability of core-shell gellan-transfersomes was established by the high deposition of baicalin in th…
Sharp capacity estimates for annuli in weighted R^n and in metric spaces
2017
We obtain estimates for the nonlinear variational capacity of annuli in weighted R^n and in metric spaces. We introduce four different (pointwise) exponent sets, show that they all play fundamental roles for capacity estimates, and also demonstrate that whether an end point of an exponent set is attained or not is important. As a consequence of our estimates we obtain, for instance, criteria for points to have zero (resp. positive) capacity. Our discussion holds in rather general metric spaces, including Carnot groups and many manifolds, but it is just as relevant on weighted R^n. Indeed, to illustrate the sharpness of our estimates, we give several examples of radially weighted R^n, which …
Bagheria e l’amministrazione Cinque Stelle (Bagheria and Five Star local government)
2016
Il paper studierà il caso di Bagheria in provincia di Palermo, Comune amministrato da Patrizio Cinque sindaco del Movimento 5 Stelle da giugno 2014. A partire dall’analisi degli elementi che ne hanno contribuito a determinare il successo elettorale (connessi allo scenario e alla campagna elettorale), si prenderanno in considerazione le peculiarità dell’amministrazione locale pentastellata nei suoi primi due anni, approfondendo in particolare la relazione tra portavoce, attivisti ed elettori prima e durante il mandato, i rapporti con gli altri Meetup locali e nazionali, le strategie comunicative, i progetti, la capacità di resistenza agli scandali che hanno colpito l’assessore all’urbanistic…
Hyvinvointivaltiokansalaisuusdiskurssit neljän suurimman puolueen eduskuntavaaliohjelmissa 1991–2019
2020
Tutkimuksen tavoitteena on tehdä näkyväksi millaisia ideologisia valintoja Suomen neljä suurinta puoluetta ovat tehneet eduskuntavaaliohjelmissaan suhteessa hyvinvointivaltiokansalaisuusdiskursseihin 1991 vuodesta alkaen. Tarkastelemme erityisesti vaaliohjelmissa tuotettuja kansalaisen poliittisia ja sosiaalisia oikeuksia ja velvollisuuksia sekä kansalaisen ja valtion välistä oikeudellinen sidettä ja sen legitimointia. Tarkastelemme puolueiden hyvinvointivaltiokansalaisuusdiskursseja pohjoismaisesta hyvinvointivaltiomallista käytävän kamppailun viitekehyksessä. Kansalaisuustulkinnat ohjaavat yhteiskuntapolitiikkaa ja esimerkiksi määritelmät kansalaisten tarpeista vaikuttavat palvelurakentee…