Search results for "DOM"

2020

Teraryl-based alpha-helix mimetics have resulted in efficient inhibitors of protein-protein interactions (PPIs). Extending the concept to even longer oligoarene systems would allow for the mimicking of even larger interaction sites. We present a highly efficient synthetic modular access to quateraryl alpha-helix mimetics, in which, at first, two phenols undergo electrooxidative dehydrogenative cross-coupling. The resulting 4,4′-biphenol is then activated by conversion to nonaflates, which serve as leaving groups for iterative Pd-catalyzed Suzuki-cross-coupling reactions with suitably substituted pyridine boronic acids. This work, for the first time, demonstrates the synthetic efficiency of …

Thiourea-Catalyzed Domino Michael–Mannich [3+2] Cycloadditions: A Strategy for the Asymmetric Synthesis of 3,3′-Pyrrolidinyl-dispirooxindoles

2017

The asymmetric synthesis of trifluoromethylated 3,3′-pyrrolidinyl-dispirooxindole derivatives with four contiguous stereogenic centers, including two vicinal spiro-stereocenters, is described. Employing a bifunctional thiourea catalyst, a domino Michael–Mannich [3+2] cycloaddition occurs readily between isatin ketimines and isatin-derived enoates with good yields and very high stereoselectivities, providing a direct entry to the title compounds of potential medical value.

Cross-Metathesis/Intramolecular (Hetero-)Michael Addition: A Convenient Sequence for the Generation of Carbo- and Heterocycles

2017

The high stability and functional group compatibility of ruthenium carbene complexes confer them a great ability to catalyze domino processes. For this reason, the combination of metathesis reactions with additional transformations in a domino fashion has been exploited extensively, with the result of expanding the utility of ruthenium carbene complexes beyond that of just olefin metathesis. Among those domino processes, it is worth mentioning the sequence of cross-metathesis/intramolecular Michael addition, which allows for the generation of a wide variety of carbo- and heterocycles in a very simple manner, taking advantage of the benefits of domino reactions. Carbon-, oxygen- and nitrogen…

SMOS Level-2 Soil Moisture Product Evaluation in Rain-Fed Croplands of the Pampean Region of Argentina

2016

A field campaign was carried out to evaluate the Soil Moisture (SM) MIR-SMUDP2 product (v5.51) generated from the data of the Microwave Imaging Radiometer using Aperture Synthesis (MIRAS) aboard the Soil Moisture and Ocean Salinity (SMOS) mission. The study area was the Pampean Region of Argentina, which was selected because it is a vast area of flatlands containing quite homogeneous rain-fed croplands, which are considered SMOS nominal land uses and hardly affected by radio-frequency interference contamination. Transects of ground handheld SM measurements were performed using ThetaProbe ML2x probes within four Icosahedral Snyder Equal Area Earth (ISEA) grid nodes, where permanent SM statio…

Controlled time integration for the numerical simulation of meteor radar reflections

2016

We model meteoroids entering the Earth[U+05F3]s atmosphere as objects surrounded by non-magnetized plasma, and consider efficient numerical simulation of radar reflections from meteors in the time domain. Instead of the widely used finite difference time domain method (FDTD), we use more generalized finite differences by applying the discrete exterior calculus (DEC) and non-uniform leapfrog-style time discretization. The computational domain is presented by convex polyhedral elements. The convergence of the time integration is accelerated by the exact controllability method. The numerical experiments show that our code is efficiently parallelized. The DEC approach is compared to the volume …

Individual Tree Detection and Classification with UAV-Based Photogrammetric Point Clouds and Hyperspectral Imaging

2017

Made available in DSpace on 2018-12-11T17:11:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01 Suomen Akatemia Small unmanned aerial vehicle (UAV) based remote sensing is a rapidly evolving technology. Novel sensors and methods are entering the market, offering completely new possibilities to carry out remote sensing tasks. Three-dimensional (3D) hyperspectral remote sensing is a novel and powerful technology that has recently become available to small UAVs. This study investigated the performance of UAV-based photogrammetry and hyperspectral imaging in individual tree detection and tree species classification in boreal forests. Eleven test sites with 4151 reference trees repr…

Kinematics, deformation partitioning and late Variscan magmatism in the Agly massif, Eastern Pyrenees, France

2020

International audience; In order to constrain the finite deformation pattern of the Variscan basement of the Agly massif, a detailed structural analysis over the whole Agly massif was performed. Our investigation combined geological mapping, reappraisal of published and unpublished data completed with our own structural work. Results are provided in the form of new tectonic maps and series of regional cross-sections through the Agly massif. At variance from previous studies, we identified three deformation fabrics named D1, D2 and D3. The D1 deformation is only relictual and characterized by a broadly northwest-southeast striking and eastward dipping foliation without any clear mineral and …

Comparison of gap-filling techniques applied to the CCI soil moisture database in Southern Europe

2021

Abstract Soil moisture (SM) is a key variable that plays an important role in land-atmosphere interactions. Monitoring SM is crucial for many applications and can help to determine the impact of climate change. Therefore, it is essential to have continuous and long-term databases for this variable. Satellite missions have contributed to this; however, the continuity of the series is compromised due to the data gaps derived by different factors, including revisit time, presence of seasonal ice or Radio Frequency Interference (RFI) contamination. In this work, the applicability of different gap-filling techniques is evaluated on the ESA Climate Change Initiative (CCI) SM combined product, whi…

Environmental change during the Early Cretaceous in the Purbeck-type Durlston Bay section (Dorset, Southern England): a biomarker approach.

2007

20 pages; International audience; The Purbeck-type section (Durlston Bay, Dorset, UK) exhibits littoral lagoonal to lacustrine facies. It shows a gradual climatic/environmental change from semi-arid conditions associated with evaporites at the Jurassic–Cretaceous transition, to a more humid climate at the end of the Berriasian. Though generally organic-poor (total organic carbon, TOC, <1.3%), the Durlston Bay section shows an organic-rich episode (TOC up to 8.5%) located at the transition from evaporitic to more humid facies. A biomarker study was performed in order to determine the origin of the organic matter (OM) in the section and see if changes in organic sources accompanied the genera…

Estudio de bofedales en los Andes ecuatorianos a través de la comparación de imágenes Landsat-8 y Sentinel-2

2019

[EN] The objective of the present study was to compare the Landsat-8 and Sentinel-2 images to calculate the wetland´s extension, distribution and degree of conservation, in Reserva de Producción de Fauna Chinborazo (RPFCH) protected area located in the Andean region of Ecuador. This process was developed with in situ work in 16 wetlands, distributed in different conservation levels. The Landsat-8 and Sentinel-2 images were processed through a radiometric calibration (restoration of lost lines or píxels and correction of the stripe of the image) and an atmospheric correction (conversion of the digital levels to radiance values), to later calculate the Vegetation spectral indexes: NDVI, SAVI …