Search results for "DOMAIN"
showing 10 items of 2485 documents
Fads and Facts of E-Government: A Review of Impacts of E-government (2003–2009)
2010
This paper analyzes the impacts of e-government as reported in 55 first-hand empirical peer-reviewed journal publications during the period 2003–2009, using a conceptual framework to identify ICT (information and communication technology) impacts on four domains within the public sector: capabilities, interactions, orientations and value distribution. The analysis shows that research findings mostly report positive impacts in all four dimensions. In the empirical research, the majority of impacts from ICT are reported within the domain of capabilities, which is also the domain that features the most balanced mix of positive and negative findings. Findings show that although e-government has…
A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior
2016
Vascular endothelial growth factor (VEGF) is known to be required for the action of antidepressant therapies but its impact on brain synaptic function is poorly characterized. Using a combination of electrophysiological, single-molecule imaging and conditional transgenic approaches, we identified the molecular basis of the VEGF effect on synaptic transmission and plasticity. VEGF increases the postsynaptic responses mediated by the N-methyl-D-aspartate type of glutamate receptors (GluNRs) in hippocampal neurons. This is concurrent with the formation of new synapses and with the synaptic recruitment of GluNR expressing the GluN2B subunit (GluNR-2B). VEGF induces a rapid redistribution of Glu…
An Open-Label Phase II Study Evaluating the Safety and Efficacy of Ramucirumab Combined With mFOLFOX-6 as First-Line Therapy for Metastatic Colorecta…
2014
Abstract Author Summary Background. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2) are believed to mediate angiogenesis in colorectal cancer (CRC). Ramucirumab (RAM; IMC-1121B) is a human IgG1 monoclonal antibody that inhibits VEGF ligand binding to VEGFR-2, inhibiting VEGFR-2 activation and signaling. Methods. Patients with metastatic CRC, Eastern Cooperative Oncology Group performance status 0–1, and adequate organ function who had not received chemotherapy for metastatic disease received RAM and the modified FOLFOX-6 regimen every 2 weeks. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety. The sample size wa…
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
2010
Inflammation drives expression of VEGFR2, which is expressed on and drives growth of tumor cells in colitis-associated cancer.
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
2011
Fibronectin (FN) is a major component of the extracellular matrix and functions in cell adhesion, cell spreading and cell migration. In the retina, FN is transiently expressed and assembled on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting angiogenesis. The precise function of FN in retinal angiogenesis is largely unknown. Using genetic tools, we show that astrocytes are the major source of cellular FN during angiogenesis in the mouse retina. Deletion of astrocytic FN reduces radial endothelial migration during vascular plexus formation in a gene dose-dependent manner. This effect correlates with reduced VEGF receptor 2 and PI3K/AKT signalli…
Tbx1 regulates Vegfr3 and is required for lymphatic vessel development
2010
Defects in lymphangiogenesis are added to the broad clinical manifestations of DiGeorge syndrome, caused by deletion of the T box transcription factor Tbx1.
Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis
2009
Survival of newly implanted retrograde-shed endometrial tissue during menstruation in an ectopic location requires an adequate blood supply. This suggests that angiogenesis is a prerequisite for the development of endometriosis and that its inhibition may be a target for preventing development. Previous studies have shown that vascular endothelial growth factor (VEGF), a heparin-binding glycoprotein, has an essential role in angiogenesis. The main regulatory factor for angiogenesis appears to be binding of VEGF to its type-2 receptor (VEGFR-2). Cabergoline (Cb2) and other dopamine agonists promote endocytosis of the VEGF receptor-2 (VEGFR-2) in endothelial cells, thereby preventing VEGF-VEG…
Common and Domain-specific Metamodel Elements for Problem Description in Simulation Problems
2014
It is well known that the multi-agent system paradigm is well suited for modelling and developing simulations of complex systems belonging to several application domains. Simulation study aims at developing simulation models useful for representing, studying and analyzing entities and their behavior in a system according to specific purposes. With our work we are trying to understand what are the right elements to be considered and included in the description of a simulation problem. In order to root our resulting metamodel in the state of the art of multi-agent simulations we started from the study of twelve papers dealing with four different application domains: Crowd Dynamics, Traffic an…
Multi-Layer Offloading at the Edge for Vehicular Networks
2020
This paper proposes a multi-layer platform for job offloading in vehicular networks. Offloading is performed from vehicles in the Vehicular Domain towards Multi-Access Edge Computing (MEC) Servers deployed at the edge of the network, and between MEC Servers. Offloading decisions at both domains are challenging for the overall system performance. Optimization at the MEC Layer domain is obtained by model-based Reinforcement Learning, while a strategy to decide the best offloading rate from the Vehicular Domain is defined to achieve the desired trade-off between costs and performance. Numerical analysis shows the achieved performance.
HINTS: A novel approach for realistic simulations of vehicular communications
2012
One of the main challenges in the Vehicular Ad-Hoc Networks (VANETs) research domain is the simulation of vehicular communications using realistic mobility models. Several efforts have been put lately in this purpose; yet, the proposed models are either inappropriate, or carry significant disadvantages. In this paper, we propose a novel approach for realistic simulations in vehicular networks, inspired from the hierarchical video and image compression technique. We developed HINTS (Hybrid Integration of Network and Traffic Simulators), the correspondent platform, engendered from the integration of SUMO, a traffic simulator and NS-3, a network simulator after adding some supplemental modules…