Search results for "DOMAIN"
showing 10 items of 2485 documents
Stem cell populations in the heart and the role of Isl1 positive cells
2013
Cardiac progenitor cells are multipotent stem cells isolated from both embryonic and adult hearts in several species and are able to differentiate at least into smooth muscle cells, endothelial cells and cardiomyocytes. The embryonic origin of these cells has not yet been demonstrated, but it has been suggested that these cells may derive from the first and secondary heart fields and from the neural crest. In the last decade, two diffe-rent populations of cardiac progenitor or stem cells have been identified and isolated, i.e., the Islet1 positive (Isl1+) and c-Kit positive (c-Kit+)/Stem Cell Antigen-1 positive (Sca-1+) cells. Until 2012, these two populations have been considered two separ…
Role of RNA Motifs in RNA Interaction with Membrane Lipid Rafts: Implications for Therapeutic Applications of Exosomal RNAs
2021
RNA motifs may promote interactions with exosomes (EXO-motifs) and lipid rafts (RAFT-motifs) that are enriched in exosomal membranes. These interactions can promote selective RNA loading into exosomes. We quantified the affinity between RNA aptamers containing various EXO- and RAFT-motifs and membrane lipid rafts in a liposome model of exosomes by determining the dissociation constants. Analysis of the secondary structure of RNA molecules provided data about the possible location of EXO- and RAFT-motifs within the RNA structure. The affinity of RNAs containing RAFT-motifs (UUGU, UCCC, CUCC, CCCU) and some EXO-motifs (CCCU, UCCU) to rafted liposomes is higher in comparison to aptamers withou…
Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells
2020
Intraluminal vesicles (ILVs) are released into the extracellular space as exosomes after the fusion of multivesicular bodies (MVBs) with the plasma membrane. miRNAs are delivered to the raft-like region of MVB by RNA-binding proteins (RBPs). RNA loading into exosomes can be either through direct interaction between RNA and the raft-like region of the MVB membrane, or through interaction between an RBP&ndash
Combining Sequence Analysis and Hidden Markov Models in the Analysis of Complex Life Sequence Data
2018
Life course data often consists of multiple parallel sequences, one for each life domain of interest. Multichannel sequence analysis has been used for computing pairwise dissimilarities and finding clusters in this type of multichannel (or multidimensional) sequence data. Describing and visualizing such data is, however, often challenging. We propose an approach for compressing, interpreting, and visualizing the information within multichannel sequences by finding (1) groups of similar trajectories and (2) similar phases within trajectories belonging to the same group. For these tasks we combine multichannel sequence analysis and hidden Markov modelling. We illustrate this approach with an …
Low-rank approximation based non-negative multi-way array decomposition on event-related potentials
2014
Non-negative tensor factorization (NTF) has been successfully applied to analyze event-related potentials (ERPs), and shown superiority in terms of capturing multi-domain features. However, the time-frequency representation of ERPs by higher-order tensors are usually large-scale, which prevents the popularity of most tensor factorization algorithms. To overcome this issue, we introduce a non-negative canonical polyadic decomposition (NCPD) based on low-rank approximation (LRA) and hierarchical alternating least square (HALS) techniques. We applied NCPD (LRAHALS and benchmark HALS) and CPD to extract multi-domain features of a visual ERP. The features and components extracted by LRAHALS NCPD…
Domain wall motion in a diffusive weak ferromagnet
2019
We study the domain wall motion in a disordered weak ferromagnet, induced by injecting a spin current from a strong ferromagnet. Starting from the spin diffusion equation describing the spin accumulation in the weak ferromagnet, we calculate the force and torque acting on the domain wall. We also study the ensuing domain wall dynamics, and suggest a possible measurement method for detecting the domain wall motion via measuring the additional resistance.
Magnetoelectric effects in superconductor/ferromagnet bilayers
2018
We demonstrate that the hybrid structures consisting of a superconducting layer with an adjacent spin-textured ferromagnet demonstrate the variety of equilibrium magnetoelectric effects originating from coupling between the conduction electron spin and superconducting current. By deriving and solving the generalized Usadel equation which takes into account the spin-filtering effect we find that a supercurrent generates spin polarization in the superconducting film which is non-coplanar with the local ferromagnetic moment. The inverse magnetoelectric effect in such structures is shown to result in the spontaneous phase difference across the magnetic topological defects such as a domain wall …
Solvability of a first order system in three-dimensional non-smooth domains
1985
summary:A system of first order partial differential equations is studied which is defined by the divergence and rotation operators in a bounded nonsmooth domain $\Omega\subset \bold R^3$. On the boundary $\delta\Omega$, the vanishing normal component is prescribed. A variational formulation is given and its solvability is investigated.
Mappings of finite distortion : boundary extensions in uniform domains
2015
In this paper, we consider mappings on uniform domains with exponentially integrable distortion whose Jacobian determinants are integrable. We show that such mappings can be extended to the boundary and moreover these extensions are exponentially integrable with quantitative bounds. This extends previous results of Chang and Marshall on analytic functions, Poggi-Corradini and Rajala and Akkinen and Rajala on mappings of bounded and finite distortion.
France After the Liberation: The Labour Movement, the Employers and the Political Leaders in Their Struggle with the Social Movement
2018
The French defeat in the spring of 1940 and the ensuing German occupation, as well as the establishment of the authoritarian Vichy regime, made it theoretically impossible for social movements to emerge; that is to say, to allow the development of mobilisation(s) and challenge(s) to authority within companies and/or against any aspect of government policy. However, in the summer of 1940 and a fortiori from 1941 onwards, resistance movements were born precisely because of their ability to convey the discontent of the French society and to use its momentum. In this sense, the French Resistance undoubtedly was a social movement, whose members were leading a ‘normal’ life as civilians under occ…