Search results for "DOMAINS"
showing 10 items of 269 documents
Geometric Properties of Planar BV -Extension Domains
2009
We investigate geometric properties of those planar domains that are extension for functions with bounded variation.We start from a characterization of such domains given by Burago–Maz'ya and prove that a bounded, simply connected domain is a BV -extension domain if and only if its com- plement is quasiconvex. We further prove that the extension property is a bi-Lipschitz invariant and give applications to Sobolev extension domains.
On the continuity of discrete maximal operators in Sobolev spaces
2014
We investigate the continuity of discrete maximal operators in Sobolev space W 1;p (R n ). A counterexample is given as well as it is shown that the continuity follows under certain sucient assumptions. Especially, our research verifies that for the continuity in Sobolev spaces the role of the partition of the unity used in the construction of the maximal operator is very delicate.
Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: A comparative study with DAG-containing docosahexaenoic acid
2006
We synthesized a diacylglycerol (DAG)-containing arachidonic acid, i.e., 1-stearoyl-2-arachidonyl-sn-glycerol (SAG), and studied its implication in the modulation of canonical transient receptor potential sub-type 6 (TRPC6) channels in stably-transfected HEK-293 cells. SAG induced the influx of Ca(2+), and also of other bivalent cations like Ba(2+) and Sr(2+), in these cells. SAG-evoked Ca(2+) influx was not due to its metabolites as inhibitors of DAG-lipase (RHC80267) and DAG-kinase (R50922) failed to inhibit the response of the same. To emphasise that SAG exerts its action via its DAG configuration, but not due to the presence of stearic acid at sn-1 position, we synthesized 1-palmitoyl-2…
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
2021
The identification of chemical compounds able to bind specific sites of the human/viral proteins involved in the SARS-CoV-2 infection cycle is a prerequisite to design effective antiviral drugs. Here we conduct a molecular dynamics study with the aim to assess the interactions of ivermectin, an antiparasitic drug with broad-spectrum antiviral activity, with the human Angiotensin-Converting Enzyme 2 (ACE2), the viral 3CLpro and PLpro proteases, and the viral SARS Unique Domain (SUD). The drug/target interactions have been characterized in silico by describing the nature of the non-covalent interactions found and by measuring the extent of their time duration along the MD simulation. Results …
Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles
2016
The proper differentiation and maintenance of myofibers is fundamental to a functional musculature. Disruption of numerous mostly structural factors leads to perturbations of these processes. Among the limited number of known regulatory factors for these processes is Mind bomb2 (Mib2), a muscle-associated E3 ubiquitin ligase, which was previously established to be required for maintaining the integrity of larval muscles. In this study, we have examined the mechanistic aspects of Mib2 function by performing a detailed functional dissection of the Mib2 protein. We show that the ankyrin repeats, in its entirety, and the hitherto uncharacterized Mib-specific domains (MIB), are important for the…
Robot Shift from Industrial Production to Social Reproduction
2015
This chapter analyses people’s attitudes towards the use of robots in the different domains of life and, specifically, in the domain of social reproduction. The analysis is based on Eurobarometer 382 “Public Attitudes towards Robots” data (N = 26,751), which was carried out among EU citizens aged 15 and over in 27 member states in 2012. The results of the study show that on average European perceptions of robots are positive and permissive. The life domains in which robots have already been used for a long time (e.g. space exploration, manufacturing, military and security business, search and rescue work) turn out to be the most popular areas for the further penetration of robots. The least…
Bending-Shear interaction domains for externally prestressed concrete girders
2013
In prestressed concrete structures, the evaluation of the safety level is generally carried out by separating the bending moment strength and the shear force capacity. Actually interaction between bending moment (M) and shear force (V) can have significant consequences on evaluations in service life, especially when the ultimate limit state (ULS) is considered. In this paper, the M-V interaction is addressed for prestressed concrete girders, in the cases of both bonded and unbonded prestressing tendons. It can be demonstrated, by drawing the interaction domains (M-V), that a significant reduction of the safety level has to be considered when shear force is evaluated together with bending mo…
Serviceability and Ultimate Safety Checks of SegmentalConcrete Bridges through N-M and M-V Interaction Domains
2015
In current engineering practice, safety checks on serviceability and determinations of ultimate limit states of segmental bridges built by cantilevering are generally performed, either considering separately the contributions of axial force N, bending moment M, and shear force V, or considering the interaction effects through approximate expressions supplied by building codes. During construction stages and service life, the interaction between internal forces can be of fundamental importance in establishing the actual degree of structural safety and, for this reason, a different philosophy for performing checks in segmental bridges is proposed in this paper, plotting N-M and M-V interactio…
Frictional effects in structural behavior of no-end-connected steel-jacketed RC columns: Experimental results and new approaches to model numerical a…
2017
Steel jacketing of reinforced concrete (RC) columns is a common retrofitting technique used to restore bearing and deformation capacity of buildings presenting structural deficiencies. For practical reasons, steel angles are in several cases arranged leaving a gap with the end beams or slabs. Despite this disconnection, the angles are still able to support a non-negligible portion of load because of the frictional forces developed along the column-angle contact interface. In these cases, the definition of computational numerical and analytical models for the assessment of reinforced cross sections becomes more complex and must be handled with care. The actual load-carrying capacity of the a…
Interaction between Longitudinal Shear and Transverse Bending in Prestressed Concrete Box Girders
2017
In box girder bridges, the quantity and distribution of reinforcement to be put in concrete elements of sections can be evaluated only by considering the deformation of the cross section in addition to the longitudinal analysis of the static scheme, establishing the entire state of stress of box sections. This leads to a need to evaluate the interaction between internal forces obtained by the global analysis and the ones obtained by the local analysis of the cross sections. The frame effect implies the elastic deformation of slabs and webs, whereas eccentrically applied loads lead to cross-section distortion with the loss of the box shape. Hence, the reinforcement is strongly influenced by …