Search results for "DONATION"
showing 10 items of 120 documents
Removal of annexin V–positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a contr…
2014
Objective To determine the effect of removing presumptive apoptotic sperm cells from samples from unselected males by means of magnetic activated cell sorting (MACS) on live-birth delivery rates after intracytoplasmic sperm injection (ICSI) in couples undergoing ovum donation (OD). Design Prospective, randomized, triple-blinded, and controlled study. Setting Private university-affiliated IVF center. Patient(s) A total of 237 infertile couples undergoing ICSI as part of an OD program. Intervention(s) Semen specimens from the control group were prepared by swim-up. Samples from the study group were prepared by swim-up followed by MACS and incubation with annexin V–conjugated microbeads to rem…
Peri-Operative Liver Regeneration of the Remnant Liver Volume after Right Hepatectomy for Living Donation: A Multiple Regression Analysis
2012
Early liver regeneration was studied in a series of 70 patients who underwent right hepatectomy for living donation from November 2004 to January 2010. Liver regeneration was evaluated by multidetector computed tomography at a mean time of 61.07 days after surgery. Pre-surgical variables such as age, weight, height, body mass index, liver function tests, creatinine, platelet count, international normalized ratio, glucose, and variables detected with preoperative multidetector computed tomography imaging, including diameter of main portal vein, steatosis, original liver volume and spleen volume, were investigated as potential predictors of liver regeneration. Future remnant liver volume was …
The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: is it hypoandrogenic?
2012
STUDY QUESTION What is the final hormonal milieu of pre-ovulatory follicles of low-responder (LR) patients undergoing unstimulated cycles? SUMMARY ANSWER Neither androgen secretion nor LH was impaired in pre-ovulatory follicles of LR women. WHAT IS KNOWN ALREADY Therapies currently used to improve ovarian response in LR women have an impact on the final hormonal follicular milieu, and these changes are believed to be partially responsible for determining the success rate in these women. Surprisingly, as far as we know, there is no report of the final hormonal profile of LR women undergoing unstimulated cycles or evidence that follicular androgen secretion in LR women is impaired. STUDY DESI…
The type of GnRH analogue used during controlled ovarian stimulation influences early embryo developmental kinetics: a time-lapse study
2013
OBJECTIVE: To explore if the GnRH analogue used for controlled ovarian stimulation (COS) and the ovulation triggering factor (GnRH agonist + hCG triggering versus GnRH antagonist + GnRH agonist triggering) affect embryo development and kinetics.STUDY DESIGN: In a retrospective cohort study in the Instituto Valenciano de Infertilidad (IVI) Alicante and the Instituto Universitario-IVI Valencia, Spain, 2817 embryos deriving from 400 couples undergoing oocyte donation were analysed. After controlled ovarian stimulation and IVF/intracytoplamic sperm injection, the timing of embryonic cleavages was assessed by a video time-lapse system. The results were analysed using Student's t test for compari…
The significance of premature luteinization in an oocyte-donation programme
2006
BACKGROUND: Several evidences indicate that premature luteinization (PL) may affect IVF outcome. The primary end-point of the present study was to verify the effect of PL on the pregnancy rate (PR) of our oocytedonation programme. METHODS: PL was defined as serum progesterone ³1.2 ng/ml on the day of HCG. We analysed retrospectively 240 oocyte-donation cycles in which 120 women donated twice, with PL in the first donation cycle and no PL in the following one, acting as its own control. Recipients (n = 240) were divided in two groups according to the presence of PL (n = 120) or not (n = 120). Both groups were compared regarding donor cycle parameters and recipient cycle outcome. RESULTS: The…
A longitudinal study of C1q and anti-C1q autoantibodies in homologous and heterologous pregnancies for predicting pre-eclampsia
2022
C1q, the recognition molecule of the classical pathway of the complement system, plays a central role in pregnancy. Lack of C1q is characterized by poor trophoblast invasion and pregnancy failure. C1q can be the target of an antibody response: anti‐C1q autoantibodies (anti-C1q) are present in several infectious and autoimmune diseases. The presence of these autoantibodies has been detected also in 2-8% of the general population. Recent evidence indicates that women who undergo assisted reproductive technology (ART) have an increased risk of developing pre-eclampsia (PE), particularly oocyte donation (OD) pregnancies. The aim of this study was to characterize the levels of C1q and anti-C1q i…
Essays on the Performance, Subsidization and Internationalization of Social Enterprises
2020
Social enterprises are hybrid organizations that tackle societal challenges by using conventional business models. Being hybrid organizations means that social enterprises pursue dual objectives: social (developmental) and financial. By taking performance, subsidization and internationalization perspectives, this thesis contributes to understanding the hybridity of social enterprises and how this hybridity drives their general operations and key decisions such as foreign market selection and targeting strategy.
Should kidney allografts from old donors be allocated only to old recipients?
2020
Contains fulltext : 226016.pdf (Publisher’s version ) (Closed access) In several deceased donor kidney allocation systems, organs from elderly donors are allocated primarily to elderly recipients. The Eurotransplant Senior Program (ESP) was implemented in 1999, and since then, especially in Europe, the use of organs from elderly donors has steadily increased. The proportion of ≥60-year-old donors reported to the Collaborative Transplant Study (CTS) by European centers has doubled, from 21% in 2000-2001 to 42% in 2016-2017. Therefore, in the era of organ shortage it is a matter of debate whether kidney organs from elderly donors should only be allocated to elderly recipients or whether <65-y…
Unethical Brotherly Love: Zell Kravinsky and Maximum Human Utility
2014
The case of American investor and philanthropist Zell Kravinsky (1956-) presents numerous ethical challenges regarding our social responsibility to others. In 2003, after disbursing the bulk of his forty-five-million-dollar fortune to various charities, Kravinsky made the decision to donate one of his kidneys to an impoverished African-American woman he had met only once. In doing so he courageously saved a life, but also incurred the wrath of his family, friends, and many observers in the media who questioned his sanity. To Kravinsky, however, refusal to donate would have been tantamount to murder, constituting a violation of his belief in ‘maximum human utility’ – a concept that insists o…
Philoscphies of the gift: Uses and abuses of contemporary ethics donation
2013
El objetivo de este artículo es analizar el concepto de donación en la ética contemporánea. Este análisis se realiza en tres momentos: el primero se sitúa en la introducción y muestra que es un concepto importante en el que convergen la fenomenología, el personalismo y la hermenéutica. Esta convergencia no solo supone un uso frecuente del concepto sino un abuso del mismo cuando se construye de espalda a las mediaciones objetivas o institucionales que lo condicionan. El segundo presenta una antropología del don y muestra su relación con los objetos, la reciprocidad, la deuda y la libertad. En el tercer momento se describe la filosofía de la donación de Paul Ricoeur, donde se comprueba un uso…