Search results for "Dama"
showing 10 items of 1437 documents
Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder
2020
Celiac Disease (CD) is an immune-mediated disease triggered by the ingestion of wheat gliadin and related prolamins from other cereals, such as barley and rye. Immunity against these cereal-derived proteins is mediated by pro-inflammatory cytokines produced by both innate and adaptive system response in individuals unable to adequately digest them. Peptides generated in this condition are absorbed across the gut barrier, which in these patients is characterized by the deregulation of its permeability. Here, we discuss a possible correlation between CD and Autistic Spectrum Disorder (ASD) pathogenesis. ASD can be induced by an excessive and inappropriate brain opioid activity during the neon…
A model for predicting the mixed-mode fatigue crack growth in a bonded joint
2013
Bonded joints are highly sensitive to the presence of defects and to the degradation phenomena, and this aspect represents the primary obstacle to their use in different structural engineering applications. Delamination in a bonded joint represents, in fact, one of the primary, most common and insidious causes of damage. In this paper, a numerical–experimental study on the crack propagation along the adhesive layer of a bonded joint specimen is carried out. Experimental study is focused on the evaluation of the damage modalities of a bonded joint when the specimens are subject to fatigue load. Experimental tests are compared with the results of several numerical analysis performed in ANSYS …
Rain on building façades
2006
Rain is one of the main causes of moisture damage to the building envelope, leading to problems such as rain penetration, frost and salt damage, discoloration by leaching, soiling by differential washing, etc. The potential of deterioration due to rain depends on the façade material, the junction of building envelope components, the overall geometry of the building, but also the presence or absence of modulation on the façade. In this paper, Computational fluid dynamics (CFD) simulations are used to analyze these effects and illustrated with examples taken in Sicily. It is firstly shown that buildings protect themselves from driving rain due to the wind blocking effect, but that façade open…
Effect of the serum from multiple sclerosis patients on an in vitro model of blood-brain barrier.
2008
Multiple sclerosis (MS) is characterized by focal inflammatory demyelination, largely due to autoimmune responses against different components of the myelin sheet. It is also generally accepted that the pathogenesis of MS consists of inflammatory and neurodegenerative phases, where demyelination should produce partially reversible clinical deficits that can remit, due to limited remyelination, while axonal degeneration produces permanent non-remitting clinical damage. It is also assumed that nervous system inflammation is initiated by autoreactive, myelin-specific T cells that permeate the blood-brain barrier and trigger a series of events leading to tissue destruction. In addition to antib…
Predicting mechanical behaviour and damage kinetics of a 3D interlock composite materials by using a multiscale approach
2012
International audience; The present work aims to investigate the mechanical behaviour and the damage kinetics of a3D interlock woven fabric composite, especially used for natural gas tanks dedicated to thetransportation industry. On the one hand, we aim at predicting the macroscopic coefficients ofthe stiffness matrix by homogenization multiscale approach. For this, we identified a basicunit cell which represents well the composite microstructure. On the other hand, damagemechanisms are analyzed: optical microscopy examinations on damaged specimens revealedseveral types of defects. We used the same multi-scale approach to assess the impact of thesedefects on the decrease of stiffness.
Ultrasound evaluation of joint damage and disease activity in adult patients with severe haemophilia A using the HEAD‐US system
2021
Introduction The Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) system and scoring scale has proven to be an accurate and time-efficient imaging method for identifying joint damage in patients with haemophilia. Aim Observational, multicentre, cross-sectional study conducted in 8 centres in Spain that assessed the joint status of adult patients with severe haemophilia A (SHA) using HEAD-US. Methods Joint status of the elbow, knee and ankle was evaluated in adults with SHA receiving on-demand (OD) treatment, or primary (PP), secondary (SP), tertiary (TP) or intermittent (IP) prophylaxis. Results Of the 95 patients enrolled, 87 received prophylaxis (6.3% PP, 38.9% SP, 43.2% …
Mouse CSB protein is important for gene expression in the presence of a single-strand break in the non-transcribed DNA strand.
2010
CSB protein is required for strand-specific repair of bulky DNA lesions in transcribed genes and mediates transcription recovery after exposure to DNA-damaging agents. We enzymatically generated DNA single-strand breaks (SSBs) with 3'-OH and 5'-phosphate termini in defined positions of a plasmid-borne gene and measured their effect on transcription in cell lines with different statuses of the Csb gene. A single SSB in the transcribed region of the gene caused significant decrease of gene expression. In all tested cell lines of mouse and human origin, a SSB in the transcribed DNA strand was less harmful for gene expression than a SSB situated in the opposing DNA strand. CSB deficiency exhibi…
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA b…
2002
The Cockayne syndrome B (CSB) gene product is involved in the repair of various types of base modifications in actively transcribed DNA sequences. To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated. These combine the deficiency of CSB with that of OGG1, a gene coding for the mammalian repair glycosylase that initiates the base excision repair of 7,8-dihydro-8-oxoguanine (8-oxoG). Compared to ogg1(-/-) mice, csb(-/-)/ogg1(-/-) mice were found to accumulate with age severalfold higher levels of oxidited purine modifications in hepatocytes, splenocytes and kidney cells. In contrast, the basal (ste…
Evaluation of radiological findings with COVID-19 lung lesions in Latvia in the view of artificial intelligence and radiologist
2022
Pēc Pasaules Veselības organizācijas datiem kopš pandēmijas sākuma kopējais ar Covid-19 saslimušo cilvēku skaits pārsniedz 500 miljonus. Mākslīgais intelekts (MI) paver plašas iespējas Covid-19 infekcijas izraisīto plaušu bojājumu diagnostikā, kas var uzlabot un atvieglojot radiologa darbu veicinot gan izmeklējuma specifitātes, gan sensitivitātes izvērtēšanas iespējas. Šī pētījuma galvenais mērķis bija salīdzināt MI un radiologa atradnes precizitāti Covid-19 radītā plaušu bojājuma izvērtēšanā un noteikt interpretācijas ierobežojumus un priekšrocības klīniskā kontekstā. Savukārt darba uzdevumi bija iepazīties un apkopot datus ar jaunāko literatūru par MI pielietošanas iespējām medicīnā. Apko…
Volcanic risk and the role of the media. A case study in the Etna area
2019
On December 24, 2018, the Etna volcano has recorded a significant eruption. Linked to this phenomenon, after a seismic swarm of 72 shocks, a 4.8-magnitude earthquake struck a large area North of Catania city, on the Eastern coast of Sicily. Six villages reported 28 injured people and damages to the building. According to seismologists the earthquake had an unusual level of magnitude. Yet, despite the real danger of this event, many people who live around the volcano, in one of the most densely populated areas of Sicily, perceived these facts in an ambivalent way. Indeed, their lives continued as before even in awareness of the natural hazard, while several media presented the situation as r…