Search results for "Dara"
showing 10 items of 111 documents
Prospective Randomized Study Comparing Myeloablative Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Stem Cell Trans…
2020
In this prospective randomized study, we compared the outcomes of single-unit umbilical cord blood transplantation (UCBT) and unmanipulated haploidentical stem cell transplantation (haplo-SCT) with post-transplantation cyclophosphamide (PTCy) in adults with hematologic malignancies. All patients received a myeloablative conditioning (MAC) regimen consisting of thiotepa, busulfan, and fludarabine, with antithymocyte globulin (ATG) added for UCBT recipients. Nineteen patients were randomized to UCBT and the other 26 to haplo-HSCT. Four patients (15%) allocated to the haplo-HSCT arm lacked a suitable donor and were crossed over to the UCBT arm. Finally, 23 underwent UCBT and 22 underwent haplo…
Combined therapy with acyclovir and adenosine arabinoside in herpes simplex encephalitis.
1987
We report a case of herpes simplex encephalitis (HSE) with initial coma and severe left-sided hemiparesis in which combined treatment with adenine arabinoside and acyclovir was followed by complete recovery. This favorable result is discussed in view of the literature of HSE treatment including experimental studies on antiviral activity of both drugs. Combined treatment may be useful in severe cases of HSE.
Phytochemical and pharmacological properties of essential oils from Cedrus species
2017
Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani…
Herbicidal potential of aqueous extracts from Melia azedarach L., Artemisia arborescens L., Rhus coriaria L. and Lantana camara L.
2017
In the search for new strategies for weed management in agricultural systems, a great interest is to use the plant extracts to replace or integrate, chemical weed control. Two experiments were done to test the effects of plant water extracts from Chinaberry (Melia azedarach L.), Tree Wormwood (Artemisia arborescens (Vaill.) L.), Sicilian Sumac (Rhus coriaria L.) and Lantana (Lantana camara L.) on seed germination of Rocket (Eruca sativa Mill.), Rapeseed (Brassica napus L.), Bladderflower (Araujia sericifera Brot.) and Psyllium (Plantago psyllium L). The water extracts (pure and 50% mixtures) from the donor species were applied on seeds of recipient plants. In second experiment in pots, thes…
Landslide susceptibility mapping using precipitation data, Mazandaran Province, north of Iran
2017
Precipitation is a nonlinear and complex phenomenon and varies in time and space. It is also evident that there is a link between precipitation and shallow landslides, and precipitation is always considered as a landslide-triggering factor. This study aims to investigate the relationship between the characteristics of precipitation and the historical shallow landslides in Mazandaran Province, north of Iran. For this purpose, the spatial variability of rainfall was analyzed using monthly rainfall data collected at 15 synoptic stations distributed over the region between 1981 and 2014. Monthly precipitation and other derived parameters were used, and a hybrid model combining principal compone…
Alemtuzumab Plus Oral Dexamethasone, Followed by Alemtuzumab Maintenance or Allogeneic Transplantation in Ultra High-Risk CLL: Updated Results From a…
2012
Abstract Abstract 716 CLL patients characterized by 17p-, TP53 mutation or refractoriness to fludarabine (F)-based therapy show a very poor prognosis (“ultra high-risk CLL”). Although alemtuzumab (A) showed efficacy in these cohorts, the rate and duration of remissions remain unsatisfactory. Aim of the CLL2O study was to achieve higher overall response rates (ORR) by adding high-dose dexamethasone (D) to A during induction and investigating the consolidation effect of prolonged A or allogeneic stem-cell transplantation (allo-SCT), respectively. Induction treatment consisted of subcutaneous A, 30 mg weekly × 3 for 28 days, combined with oral D, 40 mg on days 1–4 and 15–18, and prophylactic p…
Prospective, Observational Study To Assess The Safety Of Rituximab In Combination With Chemotherapy In Patients With Previously-Untreated Or Relapsed…
2013
Abstract Aim and Background The efficacy and safety of rituximab plus chemo (R+chemo) for first-line and relapsed B-CLL patients(pts) have been widely investigated in clinical trials and large patient cohorts, but much less is known about whether such regimens can be effectively and safely administered to unselected pts in the community setting to reflect the routine care of B-CLL pts. Therefore, this observational study was designed to characterize the type, severity and frequency of all adverse events occurring on-treatment and in the year following rituximab infusion. A secondary objective was to assess response rate (CR/nPR/PR), duration of response, disease-free survival, overall survi…
Zīmola ietekme uz pircēju rīcību patēriņa tirgū: MÁDARA UN Bio2You salīdzinājums.
2021
Bakalaura darbu veido trīs nodaļas, kā arī ievads, secinājumi, priekšlikumi, izmantotās literatūras un avotu saraksts un pielikumi Pirmajā nodaļā autore veica pētāmā jautājuma teorētisko pamatojumu, noskaidrojot zīmola teoriju un ietekmi uz pircēju. Otrajā nodaļā autore izpētīja uzņēmumu “Madara Cosmetics” un ”B2Y” uzņēmuma darbību un salīdzināja zīmolu “MÁDARA” un “Bio2You” veidojošos elementus. Trešajā nodaļa autore veica pētījumu, kurā tika veikta aptauja un intervijas ar diviem mārketinga nozares pārstāvjiem. Nobeigumā ir izstrādāti secinājumi un sniegti priekšlikumi, izmantotās literatūras saraksts un pielikumi. Darbs sastāv no 69 lapām, 4 tabulām, 33 attēliem un 3 pielikumiem.
Analytical characterisation of the biodeterioration of diterpenoid labdanic varnishes used in pictorial techniques: Sandarac and Manila copal
2014
Abstract The deterioration produced by fungal and bacterial growth on the sandarac and Manila copal, diterpenoid varnishes traditionally used as art materials, was evaluated by gas chromatography–mass spectrometry (GC–MS), and pyrolysis–gas chromatography–mass spectrometry (Py–GC–MS). Test specimens, coated with a solidified thin layer of the studied varnishes, were inoculated and incubated with selected fungi and bacteria obtained from collections and oil paintings affected by biodeterioration, and analysed by the above mentioned techniques. Significant changes were detected, showing evidence of deterioration processes caused or favoured by some of the studied microorganisms.
Feasibility of thiotepa addition to the fludarabine-busulfan conditioning with tacrolimus/sirolimus as graft vs host disease prophylaxis.
2020
In classical reduced-intensity conditioning (RIC) regimens, including the fludarabine and busulphan (BF) combination, sirolimus and tacrolimus (SIR-TAC) as graft vs host disease (GVHD) prophylaxis has shown acceptable results. The outcomes of SIR-TAC in a more intense RIC regimen as Thiotepa-fludarabine-busulfan (TBF) have been hardly investigated. This retrospective study included all consecutive patients receiving an allogeneic hematopoietic stem cell transplantation for myeloid malignancies (January 2009-2017) conditioned with either TBF or BF and receiving SIR-TAC. Patients receiving TBF presented higher non-relapse mortality (31.6 vs 12.3%,p = .01), along with shorter overall survival …