Search results for "Database"
showing 10 items of 2136 documents
In silico strategy for detection of target candidates for antibody therapy of solid tumors
2008
In contrast to earlier attempts for the identification of target candidates suitable for monoclonal antibody (mAb) based cancer therapies we concentrated on highly selective lineage-specific genes additionally preserved or even overexpressed in orthotopic cancers. In a script aided workflow we reduced all human entries of the RefSeq mRNA database to those encoding transmembrane domain bearing gene products and subjected them to BLAST analysis against the human EST database. All BLAST results were validated in a gene centric way allowing two types of data curation prior to expression profiling of matching ESTs in selected healthy tissues: (i) exclusion of questionable ESTs arising e.g. from …
Quantitative online isolation of 68Ge from 68Ge/68Ga generator eluates for purification and immediate quality control of breakthrough
2013
The breakthrough of ⁶⁸Ge from a ⁶⁸Ge/⁶⁸Ga-generator is one of the most sensitive parameters in the context of the clinical application of ⁶⁸Ga-radiopharmaceuticals. The difficulty in its determination lies in the "spectroscopic invisibility" of ⁶⁸Ge within an excess of ⁶⁸Ga. The introduced method for determining the ⁶⁸Ge content of the ⁶⁸Ge/⁶⁸Ga-generator eluate involves the quantitative separation of ⁶⁸Ga from ⁶⁸Ge, using a cation-exchanger. The eluate contains ⁶⁸Ga free of ⁶⁸Ge, which can be determined immediately, i.e. prior to the application of the ⁶⁸Ga-radiopharmaceutical.
The upgraded ISOLDE yield database – A new tool to predict beam intensities
2020
At the CERN-ISOLDE facility a variety of radioactive ion beams are available to users of the facility. The number of extractable isotopes estimated from yield database data exceeds 1000 and is still increasing. Due to high demand and scarcity of available beam time, precise experiment planning is required. The yield database stores information about radioactive beam yields and the combination of target material and ion source needed to extract a certain beam along with their respective operating conditions. It allows to investigate the feasibility of an experiment and the estimation of required beamtime. With the increasing demand for ever more exotic beams, needs arise to extend the functi…
An Atmospheric Radiosounding Database for Generating Land Surface Temperature Algorithms
2008
A database of global, cloud-free, and atmospheric radiosounding profiles was compiled with the aim of simulating radiometric measurements from satellite-borne sensors in the thermal infrared. The objective of the simulated data is to generate split-window (SW) and dual-angle (DA) algorithms for the retrieval of land surface temperature (LST) from Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) and Envisat/Advanced Along Track Scanning Radiometer (AATSR) data. The database contains 382 radiosounding profiles acquired over land, with nearly uniform distribution of precipitable water between 0.02 and 5.5 cm. Radiative transfer calculations were performed with the MODTRAN 4 code for…
A Cloudless land atmosphere radiosounding database for generating land surface temperature retrieval algorithms
2007
A database of global, cloud-free, atmospheric radiosounding profiles was compiled with the aim of simulating radiometric measurements from satellite-borne sensors in the thermal infrared. The objective of the simulation is to generate split-window (SW) and dual-angle (DA) algorithms for the retrieval of land surface temperature (LST) from Terra/Moderate Resolution Imaging Spectroradiometer (MODIS) and Envisat/advanced along track scanning radiometer (AATSR) data. The database contains 382 radiosonde profiles acquired over land, with nearly-uniform distribution of precipitable water between 0 and 5.5 cm. Radiative transfer calculations were performed with the MODTRAN 4 code. Different viewin…
Multidimensional Model Design using Data Mining: A Rapid Prototyping Methodology
2017
[Departement_IRSTEA]Ecotechnologies [TR1_IRSTEA]MOTIVE; International audience; Designing and building a Data Warehouse (DW), and associated OLAP cubes, are long processes, during which decision-maker requirements play an important role. But decision-makers are not OLAP experts and can find it difficult to deal with the concepts behind DW and OLAP. To support DW design in this context, we propose: (i) a new rapid prototyping methodology, integrating two different DM algorithms, to define dimension hierarchies according to decision-maker knowledge; (ii) a complete UML Profile, to define a DW schema that integrates both the DM algorithms; (iii) a mapping process to transform multidimensional …
A Methodology and Tool for Rapid Prototyping of Data Warehouses Using Data Mining: Application to Birds Biodiversity
2014
Data Warehouses (DWs) are large repositories of data aimed at supporting the decision-making process by enabling flexible and interactive analyses via OLAP systems. Rapid prototyping of DWs is necessary when OLAP applications are complex. Some work about the integration of Data Mining and OLAP systems has been done to enhance OLAP operators with mined indicators, and/or to define the DW schema. However, to best of our knowledge, prototyping methods for DWs do not support this kind of integration. Then, in this paper we present a new prototyping methodology for DWs, extending [3], where DM methods are used to define the DW schema. We validate our approach on a real data set concerning bird b…
The Italian multiple sclerosis register
2019
The past decade has seen extraordinary increase in worldwide availability of and access to several large multiple sclerosis (MS) databases and registries. MS registries represent powerful tools to provide meaningful information on the burden, natural history, and long-term safety and effectiveness of treatments. Moreover, patients, physicians, industry, and policy makers have an active interest in real-world observational studies based on register data, as they have the potential to answer the questions that are most relevant to daily treatment decision-making. In 2014, the Italian MS Foundation, in collaboration with the Italian MS clinical centers, promoted and funded the creation of the …
Years of life that could be saved from prevention of hepatocellular carcinoma
2016
Summary Background Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim To assess how many years of life are lost after HCC diagnosis. Methods Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18–61 y…
A relation between the curvature ellipse and the curvature parabola
2019
Abstract At each point in an immersed surface in ℝ4 there is a curvature ellipse in the normal plane which codifies all the local second order geometry of the surface. Recently, at the singular point of a corank 1 singular surface in ℝ3, a curvature parabola in the normal plane which codifies all the local second order geometry has been defined. When projecting a regular surface in ℝ4 to ℝ3 in a tangent direction, corank 1 singularities appear generically. The projection has a cross-cap singularity unless the direction of projection is asymptotic, where more degenerate singularities can appear. In this paper we relate the geometry of an immersed surface in ℝ4 at a certain point to the geome…