Search results for "Dative"
showing 10 items of 2381 documents
Chemical intervention in senescence-accelerated mice metabolism for modeling neurodegenerative diseases: an overview
2004
Abstract SAMP1 is a line of inbred mice with a pronounced misbalance between generation and neutralization of reactive oxygen species (ROS) in brain and other tissues. This results in accumulation of molecular defects in lipids, proteins and DNA moieties. The metabolic disorders appear at a very early stage of ontogenic development and induce morphological and behavioral defects manifesting from the fourth month after birth. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of these mice induced specific changes that closely resembled parkinsonian syndrome. Neuropeptide carnosine prevented toxic effects of MPTP and protected the animals against experimental parkinsonism.
Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice
2021
SummaryAging is associated with an increased risk of frailty, disability, comorbidities, institutionalization, falls, fractures, hospitalization, and mortality. Searching for strategies to delay the degenerative changes associated with aging and frailty is interesting. We treated old animals intravenously with small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) of young animals, and we found an improvement of several functional parameters usually altered with aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, and renal function. Frailty index analysis showed that 40% of old control mice were frail, whereas none of the …
Age-associated telomere shortening in mouse oocytes
2013
Abstract Background Oocytes may undergo two types of aging. The first is induced by exposure to an aged ovarian microenvironment before being ovulated, known as ‘reproductive or maternal aging’, and the second by either a prolonged stay in the oviduct before fertilization or in vitro aging prior to insemination, known as ‘postovulatory aging’. However, the molecular mechanisms underlying these aging processes remain to be elucidated. As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. This study aimed to ascertain the mechanisms underlying altered te…
NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses
2021
Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calcium-binding protein NECAB2 ensures synaptic function in the striatum by increasing mitochondrial efficiency. NECAB2 associates with early endosomes and mitochondria at striatal synapses. Loss of NECAB2 dysregulates proteins of the endosomal ESCRT machinery and oxidative phosphorylation. Mitochondria from NECAB2-deficient mice are more abundant but less efficient. These mitochondria exhibit increased respiration and superoxide production but produ…
Pharmacological prevention of eNOS uncoupling.
2013
Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). This endothelium-derived NO is a protective molecule with antihypertensive, antithrombotic and anti-atherosclerotic properties. Cardiovascular risk factors such as hypertension, hypercholesterolemia, cigarette smoking and diabetes mellitus induce oxidative stress mostly by stimulation of the NADPH oxidase. Overproduction of reactive oxygen species leads to oxidation of tetrahydrobiopterin (BH4), the essential cofactor of eNOS. In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting eNOS to a superoxide- producing enzyme. Consequently, NO …
Oxidative Status of Goats with Different CSN1S1 Genotypes Fed ad Libitum with Fresh and Dry Forages
2020
Forty late-lactation Girgentana goats were used to study the effect of diets fed ad libitum and &alpha
Effects of Sulla forage (Sulla coronarium L.) on the oxidative status and milk polyphenol content in goats
2015
Abstract Twelve milking Girgentana goats were allocated into 3 groups and fed 3 diets ad libitum in a 3 × 3 Latin square design with 3 periods. The diets were Sulla fresh forage ad libitum (SUL), Sulla fresh forage ad libitum and 800 g/d of barley meal (SULB), and mixed hay ad libitum and 800 g/d of barley meal (HB). Changes were observed in total polyphenol intake, plasma oxidative status, plasma polyphenol content, metabolic status, milk polyphenol content, and total antioxidant capacity. The fresh forage diets (SUL and SULB) increased dry matter, total polyphenol, nontannic polyphenol and tannin intakes, and the milk total protein, casein, milk total polyphenols, and milk free polyphenol…
Effects of diet and genotype at CSN1S1 locus on the oxidative stress in lactating goats
2011
Twenty-eight Girgentana goats were selected on the basis of their CSN1S1 genotype as follows: 14 goats homozygous for strong (AA) alleles and 14 goats heterozygous (AF). The goats were used in a 2 x 4 factorial arrangement of treatments, with the two genotypes (G) and four diets (D). The diets were: a pelleted alfalfa hay (100H), a complete feed including alfalfa hay at 65% (65H), fresh sulla (Hedysarum coronarium L.) forage (100S) and fresh sulla plus barley (65S). Each trial consisted of 15d for adaptation and 8d for sample collection, during which the goats received the scheduled diet ad libitum. Blood samples were collected at the end of pre-experimental and experimental period. Plasma …
Effects of feeding diets supplemented with fungus myceliated grains on some production, health and oxidation traits of dairy ewes.
2017
The beneficial properties of mushrooms bioactive compounds indicate their potential use as performance enhancing natural additive for livestock animals. This paper reports the preliminary results of a research on the effects of diets supplemented with fungus myceliated grains (FMG) to lactating ewes in terms of intestinal parasites control, milk production and cheese oxidative stability. During 8 weeks, 21 ewes were divided into 3 groups fed with hay ad libitum and 1.3 kg/day per head of one of 3 concentrates with 0, 10 or 20% of FMG. In front of analogous DM and nutrients intake, the ewes fed FMG at higher levels showed a reduction of intestinal parasite infection, a tendency to improve mi…
Effects of Grazing on the Behaviour, Oxidative and Immune Status, and Production of Organic Dairy Cows
2019
This study compared the effects of a short daily grazing time with those of permanent free-stall housing on the behaviour, oxidative status, immune response, and milk production of organically reared cows. During a 63-day period, two homogeneous groups of eight lactating Brown cows were allocated to either housing (H) in a free-stall building for 24 h/day. Feeding was based on a total mixed ration or grazing (G) on barley grass for 5 h/day, and housing in a free-stall structure with feeding was based on the same total mixed ration offered to the H group. With regard to behaviour, H cows spent more time idling, walking, drinking, and self-grooming, whereas G cows showed a greater intent to e…