Search results for "Deconvolution"
showing 10 items of 82 documents
Levels in the interpretive optimisation of selectivity in high-performance liquid chromatography: a magical mystery tour.
2006
Interpretive approaches for selectivity optimisation, which are those supported by retention models, are able to exploit efficiently the capabilities of the chromatographic system. The resolution of a mixture is usually faced in a first trial by looking for a unique experimental condition, able to resolve all compounds in the sample. If this is not possible, the problem can be outlined with less ambitious aims, focusing on only some compounds. In an extreme case, a single analyte can be individually optimised. Current strategies that give answer to the different goals pursued in the analysis, which are classified as total, partial and specific, are reviewed. Optimisation oriented to deconvo…
Net analyte signal as a deconvolution-oriented resolution criterion in the optimisation of chromatographic techniques
2003
The performance of two multivariate calibration measurements, multivariate selectivity (SEL(s)) and scalar net analyte signal (scalar NAS), as chromatographic objective functions (COFs), was investigated. Since both assessments are straightforwardly related to the quantification of analytes in the presence of interferents, they were expected to confer new features in the optimisation of compound resolution, not present in conventional assessments. These capabilities are especially interesting in situations of low resolution, where peak deconvolution becomes an attractive alternative. For comparison purposes, chromatographic resolution (R(s)) and peak purity (p(s)) were used as reference COF…
Global treatment of chromatographic data with MICHROM
1997
Abstract The program MICHROM for the general treatment of chromatographic data is presented. MICHROM takes part in all the stages of the analytical process. It allows determination of dead time, smoothing of chromatograms, measurement of peak parameters, fitting of skewed peaks, and deconvolution of overlapped peaks. Tools for the experimental design, optimization of the mobile phase composition to resolve a mixture of analytes, and simulation of chromatograms in several experimental conditions, are implemented. Routines for the graphical representation of chromatograms, resolution surfaces, contour maps, management of data series, optimization and regression analysis, are also included. Th…
Development of the H-point standard additions method for coupled liquid chromatography and UV-visible spectrophotometry
1992
Abstract This work establishes the fundamentals of the H-point standard additions method for liquid chromatography for the simultaneous analysis of binary mixtures with overlapped chromatographic peaks. The method was compared with the deconvolution method of peak suppression and the second derivative of elution profiles. Different mixtures of diuretics were satisfactorily resolved.
Mass/charge balance as a tool to estimate dimensional change in polypyrrole-based actuators
2006
The deconvolution of the voltammograms of polypyrrole electrochemistry has proved to be possible through the electrochemical quartz crystal microbalance data using the F(dm/dQ) function. This deconvolution allows the evolution of the thickness of the polypyrrole films during their redox processes to be estimated and therefore, the mechanical contraction/decontraction of this polymer as a function of the ionic exchange processes can be evaluated. Keywords: Polypyrrole, EQCM, Thickness change
Experiments with an adaptive Bayesian restoration method
1989
Abstract This paper describes a Bayesian restoration method applied to two-dimensional measured images, whose detector response function is not completely known. The response function is assumed Gaussian with standard deviation depending on the estimate of the local density of the image. The convex hull of the K -nearest neighbours ( K NN) of each ‘on’ pixel is used to compute the local density. The method has been tested on ‘sparse’ images, with and without noise background.
Beam deconvolution in noisy CMB maps
2003
The subject of this paper is beam deconvolution in small angular scale CMB experiments. The beam effect is reversed using the Jacobi iterative method, which was designed to solved systems of algebraic linear equations. The beam is a non circular one which moves according to the observational strategy. A certain realistic level of Gaussian instrumental noise is assumed. The method applies to small scale CMB experiments in general (cases A and B), but we have put particular attention on Planck mission at 100 GHz (cases C and D). In cases B and D, where noise is present, deconvolution allows to correct the main beam distortion effect and recover the initial angular power spectrum up to the end…
MRI resolution enhancement using total variation regularization
2009
We propose a novel method for resolution enhancement for volumetric images based on a variational-based reconstruction approach. The reconstruction problem is posed using a deconvolution model that seeks to minimize the total variation norm of the image. Additionally, we propose a new edge-preserving operator that emphasizes and even enhances edges during the up-sampling and decimation of the image. The edge enhanced reconstruction is shown to yield significant improvement in resolution, especially preserving important edges containing anatomical information. This method is demonstrated as an enhancement tool for low-resolution, anisotropic, 3D brain MRI images, as well as a pre-processing …
Numerical analysis of density gradient centrifugation profiles from eukaryotic DNA
1990
A numerical method for the deconvolution of superimposed Gaussian distributions with a unique solution has been proposed by Medgyessy [10]. We have tested the usefulness of this method for the analysis of density gradient centrifugation profiles from eukaryotic DNA, which are normally composed from overlapping Gaussian distributed profiles of several subcomponents with different mean buoyant densities. From the analysis of human DNA and from model calculations we conclude that major subcomponents can be identified by this method, if they differ in their buoyant density by approximatly 0.005 g/ml. Minor components can only be identified if the total DNA has been fractionated according to buo…
Residence time distribution of solid particles in a continuous, high-aspect-ratio multiple-impeller stirred vessel
2004
Abstract In this paper experimental information on the retention time distribution (RTD) of solid particles in a high-aspect-ratio vessel, stirred by three equally spaced Rushton turbines, is presented. The relevant data were obtained by a special technique named twin system approach (TSA) that greatly simplifies the handling of particle-laden streams and is therefore particularly suited for investigating particle RTD in flow systems. The technique fundamentals are first summarized, together with the data analysis procedure. This lastly requires a numerical deconvolution operation that is easily performed with the help of Z -transforms. Two different approaches for excluding the spurious co…