Search results for "Delirium"
showing 10 items of 66 documents
Personalized Goal for Dyspnea and Clinical Response in Advanced Cancer Patients
2018
Abstract Background The clinical response after comprehensive symptom management is difficult to determine in terms of a clinically important difference. Moreover, therapies should try to reach the threshold perceived by the individual patient for the determination of a favorable response to a treatment. Measures The Edmonton Symptom Assessment Score (ESAS) was measured at admission (T0), and seven days after starting palliative care (T7). Patient Global Impression and Goal Response after one week of palliative care and its relation with the Personalized Dyspnea Goal were measured at T7. Intervention Patients admitted to palliative care units underwent a comprehensive symptom assessment by …
Association of a CB1 Cannabinoid Receptor Gene (CNR1) polymorphism with severe alcohol dependence
2002
Abstract Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene ( CNR1 ) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe withdrawal syndromes ( P =0.010). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium ( P =0.031, DF 2), suggesting s an increased risk of delirium (OR=2.45, 95% CI 1.14…
Prevalence and features of delirium in older patients admitted to rehabilitation facilities
2022
Background: Delirium is thought to be common across various settings of care; however, still little research has been conducted in rehabilitation. Aim: We investigated the prevalence of delirium, its features and motor subtypes in older patients admitted to rehabilitation facilities during the three editions of the “Delirium Day project”. Methods: We conducted a cross-sectional study in which 1237 older patients (age ≥ 65 years old) admitted to 50 Italian rehabilitation wards during the three editions of the “Delirium Day project” (2015 to 2017) were included. Delirium was evaluated through the 4AT and its motor subtype with the Delirium Motor Subtype Scale. Results: Delirium was detected i…
Sedation and analgesia during noninvasive ventilation (NIV)
2017
The use of noninvasive ventilation (NIV) has increased significantly in patients with acute respiratory failure (ARF) in order to prevent tracheal intubation and its complications. Unfortunately, NIV failure represents a frequent event, with rates that in some cases reach 40%. Mask intolerance, agitation, and delirium may lead to NIV failure, thus requiring endotracheal intubation. NIV failure rates are higher in patients without chronic obstructive pulmonary disease (COPD), and, when used in acute hypoxemic failure, its failure is associated with an increased mortality rate. The practice of sedation during NIV could be a valuable option for patients at risk of intubation. Sedation may decr…
Medico-legal study of death in custody by excited delirium. A case report
2014
En este artículo exponemos los resultados de la autopsia de un varón joven que falleció en el hospital por un cuadro de delirium agitado. Es un síndrome caracterizado generalmente por agitación psicomotriz, agresividad y puede producir muerte súbita, en ocasiones durante la aplicación de métodos de contención mecánica por los Cuerpos de Seguridad del Estado o personal sanitario. Está típicamente asociado al consumo de drogas de abuso, como la cocaína. En estos casos, estará incluida en el grupo de muertes en custodia, que es aquella que se produce cuando la víctima se encuentra privada de libertad. Tiene una indudable repercusión médico legal, puesto que se considera prototipo de muerte sos…
GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
2005
N-Methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily, are generally inhibited by alcohol. The expression and alternative splicing of the obligatory NR1 subunit is altered by alcohol exposure, emphasizing the involvement of the NR1 subunit, which is coded by the GRIN1 gene, in alcohol-mediated effects. We performed an association study in patients with alcohol dependence with the GRIN1 locus. Two independent case control samples consisting of a total of 442 alcohol-dependent patients and 442 unrelated controls were included. There was no overall difference in allele or genotype frequency between patients and controls. However, the 2108A allele and A-co…
Post-operative ileus in elderly patients
2009
Materials and methods Data collected from 20 patients undergoing right hemicolectomy for right bowel cancer were evaluated. Patients included were divided in two groups of 10 subjects respectively, according their age. In the first group were allocated patients of age ≥ 70 years, whereas in the second group were included subjects of age ≤ 60 years. Patients affected by postoperative delirium or presenting complications that could altered the regain of intestinal motility were excluded. The time of first passage of flatus, the time of first defecation and the postoperative stay were evaluated.
Spermiogrammbefunde bei männlichen Patienten nach Alkoholdelir
2009
Zusammenfassung Bei 30 Patienten mit alkoholtoxischem Delir wurden die wichtigsten Spermiogramm-Parameter untersucht: Es wurden bei verminderter Spermatozoendichte von im Mittel 18 Mill.Sp./ml gehauft eine Hypospermie (n = 8) beobachtet. Beurteilt man Spermatozoendichte, Morphologie und Motilitat, so erweisen sich 29 der 30 Untersuchten Spermiogramme als stark pathologisch verandert. Die Spermiogenese-Storung ist bei erhohter FSH-Basiswerten (n = 10) und bei akuter alkoholtoxischer Hepatitis (n = 4) am ausgepragtesten (2a = 0.01), hangt dagegen weniger vom Trinkerstadium nach Jellinek, erhohten Ostradiol-Werten (n = 6) oder erhohten CK-Werten (n = 8) ab. Bei Alkoholkranken bei offensichtlic…
The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design
2017
Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical…
Current characteristics and early functional outcome of older stroke patients: a population-based study (Dijon Stroke Registry)
2020
Abstract Background the ongoing growing and ageing population is associated with an increase in older patients suffering a stroke. We aimed to assess the current profile of these patients in a population-based setting. Methods all patients with acute stroke were prospectively identified among residents of Dijon, France, between 2013 and 2017, using a population-based registry. Characteristics and early outcome of patients were compared according to age groups. Results 1,288 stroke cases were recorded (median age: 81.1 years, interquartile range: 66.1–86.7, 54% women). Patients aged 75–85 years and those >85 years accounted for 27.6 and 33.9% of overall cases. Increasing age was assoc…