Search results for "Deme"
showing 10 items of 883 documents
Effect of antibodies against cytochrome P-450 on demethylation and denitrosation of N-nitrosodimethylamine and N-nitrosomethylaniline.
1988
Rat liver microsomes which were induced either with ethanol or PB were incubated with NDMA or NMA. Formaldehyde generation and nitrite formation were measured as metabolic parameters for oxidative bioactivation and denitrosation, respectively. The influence of antiserum PB3a1 and PB22 containing antibodies against the corresponding cytochrome P-450 species on both metabolic functions was investigated. The results showed that the influence on formaldehyde production and denitrosation varied independently in that both parameters were either not affected, or influenced in an opposite way, or inhibited to a different degree. Especially remarkable was the 80% inhibition of formaldehyde generatio…
Lymphocytes from young healthy persons carrying the ApoE4 allele overexpress stress-related proteins involved in the pathophysiology of Alzheimer's d…
2012
Abstract Apolipoprotein E4 (ApoE4) is a major genetic risk factor for the development of Alzheimer's disease (AD). The aim of this work was to find if carrying ApoE4 alleles correlates with molecular changes associated with specific processes involved in AD pathophysiology and whether they are useful as early biomarkers of AD. Fifty four young healthy adults (aged 20-55) were recruited. Of these, 33 carried at least one ApoE4 allele and 21 did not (ApoE 3/3). We also recruited eleven patients with clinical diagnoses of probable AD and nine persons of similar age without dementia who served as controls of the AD patients. Using peripheral lymphocytes, we measured RNA expression of glycogen s…
Tumor necrosis factor alpha polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population.
2003
A pathogenic role of inflammatory factors has been proposed both in Alzheimer's disease (AD) and vascular dementia (VD). A previous report indicated the presence of polymorphism C-850T of tumor necrosis factor (TNF) alpha as a genetic risk factor for VD and, associated with apolipoprotein E epsilon 4, for AD. We have assessed the association between TNF-alpha polymorphism and dementias in Italian populations of AD, VD and elderly controls. The influence of TNF-alpha polymorphism on dementia has not been confirmed in this segment of the Italian population.
Isolated, Subtle Neurological Abnormalities in Mild Cognitive Impairment Types.
2019
Isolated, subtle neurological abnormalities (ISNA) are commonly seen in aging and have been related to cerebral small vessel disease (SVD) and subcortical atrophy in neurologically and cognitively healthy aging subjects.To investigate the frequency of ISNA in different mild cognitive impairment (MCI) types and to evaluate for each MCI type, the cross-sectional relation between ISNA and white matter hyperintensities (WMH), lacunes, caudate atrophy, and ventricular enlargement.One thousand two hundred fifty subjects with different MCI types were included in the analysis and underwent brain magnetic resonance imaging. WMHs were assessed through two visual rating scales. Lacunes were also rated…
Arrêt des poursuites individuelles. Sous-traitant, Action directe contre le maître de l'ouvrage, Obligation de mettre en demeure l'entrepreneur princ…
1993
International audience; (Rép. quest. écrite n° 51711 : JO Ass. nat. (Q), 25 mai 1992, p. 2356)
The onset of the rainy season and farmers’ sowing strategy for pearl millet cultivation in Southwest Niger
2011
A multi-year (2004-2009) field survey of on-farm sowing practices in 10 villages located in south-west Niger close to Niamey, is analysed to investigate the relationships (i) between rainfall and the sowing date of pearl millet and the risk of sowing failure, (ii) between sowing and meteorological/agro-climatic onset dates, (iii) between sowing/onset dates, and simulated and observed yield/biomass at the end of the season. Even if some villages sow without any synchronous or anterior rainfall, most parcels (73% out of the 1551 available cases) are sown during and just after a 2-day wet spell receiving at least 10 mm. In fact, there is a strong correlation (r = 0.82-0.95 depending on onset d…
Autobiographical memory for the differential diagnosis of cognitive pathology in aging
2015
Aim The present study distinguishes three memory stages across the lifespan, and aims to compare episodic and semantic autobiographical memory in healthy older adults, with amnesic mild cognitive impairment, and with Alzheimer's disease. This information can offer evidence about the way semantic and episodic autobiographical memory work, and how the disease affects them. Methods The sample was composed of 56 people, all aged over 60 years; 15 with amnestic mild cognitive impairment, 12 with Alzheimer's disease and 29 healthy older people. Participants were evaluated with the Autobiographical Memory Interview. Results A mixed anova showed significant main effects of memory and time-period, a…
Quand le sport (dés)oriente les parcours des jeunes
2020
Référence interne : 20013; Axé sur la transition lycée-enseignement supérieur, ce rapport souligne la diversité des parcours vécus par des bacheliers et notamment des bacheliers professionnels dans le secondaire, en montrant leurs rapports pluriels aux études. Il étudie tout particulièrement comment des expériences et investissements sportifs peuvent impacter les orientations des jeunes, voire leur donner un tour inattendu, à l'image des bacheliers professionnels en STAPS ou des jeunes filles en filière masculine. L’expérience en lycée professionnel peut être perçue par certains comme une possibilité d'apprendre un métier ou d’obtenir le baccalauréat, d'autres la vivent comme une fermeture …
The Economic Returns to Investment in Project-Related Training : Some Evidence from World Bank Projects
1988
International audience; Cet article évalue l'efficacité des investissements dans la formation axée sur un projet (FAP) en vue de combler le manque de compétences techniques constaté au sein des populations de projet. Les données servant à l'analyse proviennent de 115 études de la Banque Mondiale de projets agricoles ou autres (transport, vie urbaine, produits chimiques, manufacture). Contrairement à de nombreuses autres études, l'article présent ne se base pas sur les données relatives aux salaires pour calculer les taux pertinents de rentabilité, utilisant plutôt le succès d'un projet pour en mesurer les acquis. Ces derniers indiquent que la FAP rapporte d'importants bénéfices dans les pro…