Search results for "Derivative"
showing 10 items of 1074 documents
Forecasting Weekly Electricity Prices at Nord Pool
2007
This paper analyses the forecasting power of weekly futures prices at Nord Pool. The forecasting power of futures prices is compared to an ARIMAX model of the spot price. The time series model contains lagged external variables such as: temperature, precipitation, reservoir levels and the basis (futures price less the spot price); and generally reflects the typical seasonal patterns in weekly spot prices. Results show that the time series model forecasts significantly beat futures prices when using the Diebold and Mariano (1995) test. Furthermore, the average forecasting error of futures prices reveals that they are significantly above the settlement spot price at the ‘delivery week’ and th…
Development and Scale-Up of the Electrochemical Dehalogenation for the Synthesis of a Key Intermediate for NS5A Inhibitors
2015
The electrochemical 2-fold dehalogenation of a spirocyclopropane-proline derivative at leaded bronze was scaled-up in a divided batch-type electrolysis cell in good yield and excellent selectivity. The upscaling via a flow electrolysis cell was also successful. Conditions were elaborated employing a single cell passage for complete conversion. The keys here are the direct cooling of the cathode and ensuring a good laminar flow.
On the nature of organic electron density transfer complexes within molecular electron density theory.
2019
The structural features of a series of organic molecular complexes formed between the strong electrophilic tetracyanoethylene and twelve benzene derivatives with increased nucleophilic character, herein called Electron Density Transfer Complexes (EDTCs), have been studied using Molecular Electron Density Theory. The favourable nucleophilic/electrophilic interactions, which favour the global electron density transfer (GEDT) towards the electrophile, are responsible for the formation of these species. Molecular complexes presenting a GEDT above 0.05e are classified as EDTCs. Analysis of the Parr functions of the separated reagents and the topological analysis of the electron density of the ED…
Enantiomerization of an inherently chiral resorcarene derivative: determination of the interconversion barrier by computer simulation of the dynamic …
2001
Abstract The inherently chiral tetrabenzoxazine resorcarene derivative 1 shows characteristic plateau-formation during enantioselective HPLC separation on the chiral stationary phase Chiralpak AD. By computer assisted peak form analysis of the elution profiles, obtained from temperature dependent dynamic HPLC (DHPLC) experiments, with ChromWin, the enantiomerization barrier Δ G # (298 K)=92±2 kJ mol −1 and the activation parameters Δ H # =53.0±1.8 kJ mol −1 and Δ S # =−131±14 J (K mol) −1 were determined.
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
2004
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyeli…
Deterministic and Random Vibration of Linear Systems with Singular Parameter Matrices and Fractional Derivative Terms
2021
Both time- and frequency-domain solution techniques are developed for determining the response of linear multi-degree-of-freedom systems exhibiting singular parameter matrices and endowed with derivative terms of noninteger orders modeled as rational numbers. This is done based on the Moore-Penrose matrix inverse theory, in conjunction with a state variable formulation and with a complex modal analysis treatment. It is worth noting that, for the class of systems considered herein, this treatment also yields decoupled governing equations, thus facilitating further their numerical solution. Next, a generalization of the standard frequency-domain input-output (excitation-response) relationship…
Finite-Difference Time-Domain Simulation of Tower and Grounding Subjected to Lightning
2015
In this paper the behavior of a tower and its grounding system, subjected to a lightning, is faced. Finite difference time domain (FDTD) method has been chosen in order to study the non-linear time domain behavior of the system. The electromagnetic problem has been described by using two type of first order time derivative equations: Maxwell's equations and Telegraph equations. Aim of this work is to evaluate the possibility of a flashover between tower and power line, by considering different cases of study.
Innovative modeling of tuned liquid column damper controlled structures
2016
In this paper a different formulation for the response of structural systems controlled by Tuned Liquid Column Damper (TLCD) devices is developed, based on the mathematical tool of fractional calculus. Although the increasing use of these devices for structural vibration control, it has been demonstrated that existing model may lead to inaccurate prediction of liquid motion, thus reflecting in a possible imprecise description of the structural response. For this reason the recently proposed fractional formulation introduced to model liquid displacements in TLCD devices, is here extended to deal with TLCD controlled structures under base excitations. As demonstrated through an extensive expe…
A Robustness Approach to Reliability
2012
Reliability of products is here regarded with respect to failure avoidance rather than probability of failure. To avoid failures, we emphasize variation and suggest some powerful tools for handling failures due to variation. Thus, instead of technical calculation of probabilities from data that usually are too weak for correct results, we emphasize the statistical thinking that puts the designers focus on the critical product functions. Making the design insensitive to unavoidable variation is called robust design and is handled by (i) identification and classification of variation, (ii) design of experiments to find robust solutions, and (iii) statistically based estimations of proper safe…
Analysis of enantiomers giving partially overlapped peaks by using different treatments of the chromatographic ultraviolet signals: quantification of…
2001
Abstract Different strategies for the quantification of partially coeluting optical isomers have been investigated. The methods tested are based on the use of different features as the analytical UV signals: peak heights, perpendicular drop areas, first and second derivatives of the chromatograms, peak areas obtained by deconvolution of the overlapped peaks with data fitting optimization, and a multivariate model (principal component regression, PCR). The amphetamine-derivative drug pseudoephedrine was selected as a model compound. For chromatography, LiChrospher 100 RP 18 and a mobile-phase consisting of methanol and a solution of carboxymethyl-β-cyclodextrin (the chiral selector) were use…