Search results for "Dermatitis"

T-Cell Vaccination in Patients with Nickel Allergic Contact Dermatitis

1995

Reproducibility of irritant patch test reactions to sodium lauryl sulfate in a double-blind placebo-controlled randomized study using clinical scorin…

1999

Reading of doubtful patch test reactions can be improved by comparing them to defined negative, allergic and irritant controls. For the latter, an irritant patch test is needed that gives sufficiently reproducible results. In our double-blind, placebo-controlled. randomized study, we have analysed the synchronous reproducibility of patch tests with 0%, 0.0625%, 0.125%, 0.25%, 0.5% and 1.0% sodium lauryl sulfate (SLS). Tests and readings were done according to ESCD guidelines. 139 patients (75 women, 64 men) 18 to 77 years old were tested. The % of positive patients as well as the % of reproducible positive reactions increased with rising concentrations of SLS to a maximum of approximately 9…

Vitamin D, allergies and asthma: focus on pediatric patients

2014

In recent years, the interest of the scientific world towards vitamin D gradually increased, and several studies have been conducted to dissect its possible role in modulating the development/course of allergic diseases. Also, Vitamin D supplementation has been assessed as a beneficial approach for treating allergies in some, but not all studies. We reviewed herein the available and relevant literature concerning the possible links between Vitamin D, its supplementation and allergic diseases. A literature search was made independently by the Authors, identifying articles for a narrative review. As per literature, Vitamin D plays a key role in calcium and phosphate metabolism, and it is esse…

Desarrollo de formulaciones de liberación controlada para enfermedades inflamatorias

2022

Las enfermedades inflamatorias con componente autoinmune de la piel y del tracto gastrointestinal, como son la psoriasis y la dermatitis atópica y la enfermedad inflamatoria intestinal, respectivamente, son enfermedades prevalentes que necesitan mejorar su tratamiento. La ciclosporina A es un fármaco inmunosupresor que ha demostrado ser efectivo para el tratamiento de enfermedades autoinmunes, pero también sus efectos adversos a nivel sistémico. En el caso de las enfermedades cutáneas, la administración por vía tópica de este fármaco aportaría grandes ventajas como la posibilidad de actuar a nivel local y evitar efectos sistémicos. Sin embargo, la ciclosporina A presenta un tamaño molecular…

Is cytokine expression responsible for differences between allergens and irritants?

1996

Abstract Irritant and allergic contact dermatitis are two very similar diseases, and differentiating between these two can be difficult clinically. Recently, cytokines have been identified as useful tools for differentiation. Thus, our laboratory has identified an early cytokine pattern in the induction phase of contact sensitivity that is specific for allergens and is not found after epicutaneous application of irritants or tolerogens. The upregulation of the Langerhans' cell—derived signal interleukin (IL)-1β early after allergen application especially seems to be highly specific for contact allergens. This cytokine was also found to be essential for the development of epicutaneous sensit…

The spectrum of allergic (cross-)sensitivity in clinical patch testing with 'para amino' compounds

2002

Background: Allergic contact sensitization to ‘para amino’ compounds is frequent and the spectrum of cross-reactivity between members of this chemical group is variable. Methods: A retrospective analysis of clinical patch test data obtained with a special test series in the centres of the Information Network of Departments of Dermatology (IVDK) between 1995 and 1999. Results: In the 638 patients tested with the above test panel positive reactions were observed most often to p-aminoazobenzene (16.2%), p-phenylenediamine (14.1%), p-toluylenediamine (10.0%), followed by 4,4′-diaminodiphenylmethane (8.5%), Disperse Orange 3 (8.4%) and p-aminophenol (3.1%). Among the 544 patients tested with p-p…

Current management of atopic dermatitis and interruption of the atopic march.

2003

Treatment of atopic dermatitis requires a comprehensive approach that includes evaluation of potential triggers and education of the patient and family regarding proper avoidance measures. Hydration of the skin and maintenance of an intact skin barrier remain integral to proper management. Although topical corticosteroids have been a mainstay of anti-inflammatory therapy, the newer topical calcineurin inhibitors offer advantages for treatment of this chronic, relapsing disease. Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis.

Contact dermatitis caused by iodopropynyl butylcarbamate in Denmark

2013

Iodopropynyl butylcarbamate (IPBC) is a preservative that may cause contact allergy. The first cases were reported in 1997, and IPBC is currently included in our extended European baseline series in Denmark. The authors assess trends during the period 2000-2011 concerning IPBC allergy in Denmark, and address the question of the significance of concomitant reactions to the thiuram mix. Patients/materials/methods Nine thousand seven hundred and fifty-five (6449 female; 3306 male) patients were patch tested with IPBC and the European baseline series at Gentofte Hospital during 2000-2011. The results were registered in an anonymized database, and analyzed with spss™. Fifty-four cases of IPBC co…

Patch testing in children--recommendations of the German Contact Dermatitis Research Group (DKG).

2007

Summary Allergic contact dermatitis occurs frequently in children. Patch testing is needed to identify the responsible allergens and should be performed in children. We recommend a panel of 12 contact allergens as a standard series in children from 6–12 years. Four additional contact allergens should be tested in case of a positive history or suggestive clinical picture. For patch testing in children, the allergens should be applied for 24 hours and the readings should be performed at 48 and 72 hours. Standardized patch testing makes it possible to systematically investigate allergic contact dermatitis and identify relevant allergens in children.

Review of biologics in allergic contact dermatitis

2020

The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes its management challenging. With advances in the understanding of the cellular and molecular pathogenesis of ACD, newer therapeutic targets are becoming apparent. In particular, the use of biologics has gained momentum, given the specificity of their action. This article aims to review the presently available data on the use of biologics in ACD. English-language-based literature available on the use of biological therapy was thoroughly probed in the following databases as on October 14, 2019: PubMed, Google Scholar, The Cochrane library, Embase, Scopus, and EBSCO. The following keywords were used: "conta…