Search results for "Development"
showing 10 items of 26949 documents
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
2019
In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in gene therapy has had a great impact in the medical field, holding enormous promise, becoming “the latest generation medicine” with the first ever siRNA-lipid based formulation approved by the United States Food and Drug Administration (FDA) for human use, and currently on the market under the trade name Onpattro™. The growth of such powerful biologic therapeutics has gone hand in hand with the progress in delivery systems technology, which is absolutely required to improve their safety and effectiveness. Lipid carrier systems, particularly liposomes, have been proven to be the most su…
Comparison between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections
2020
Citrus species extracts are well known sources of bio-functional compounds with health-promoting effects. In particular, essential oils are known for their antibacterial activity due to the high content of terpenes. In this work, the steam-distilled essential oil from the leaves of Citrus limon var. pompia was loaded in phospholipid vesicles. The physico-chemical characteristics of the essential oil loaded vesicles were compared with those of vesicles that were loaded with citral, which is one of the most abundant terpenes of Citrus essential oils. The biocompatibility of the vesicles was assessed in vitro in human keratinocytes. Furthermore, the antimicrobial activity of the vesicles was t…
Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties
2021
Magnolia spp. extracts are known for their use in traditional Korean, Chinese, and Japanese medicine in the treatment of gastrointestinal disorders, anxiety, and allergies. Among their main components with pharmacological activity, the most relevant are magnolol and honokiol, which also show antitumoral activity. The objectives of this work were to study some physicochemical properties of both substances and their stability under different conditions of temperature, pH, and oxidation. Additionally, liposomes of honokiol (the least stable compound) were formulated and characterized. Both compounds showed pH-dependent solubility, with different solubility–pH profiles. Magnolol showed a lower …
Extracellular Vesicles as Biological Shuttles for Targeted Therapies.
2019
The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)—specialized membrane-bound nanocarriers for intercellular communication—suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical iss…
Evidence of autoinduction heterogeneity via expression of the agr system of listeria monocytogenes at the single-cell level
2011
ABSTRACT To investigate if the primary function of the Agr system of Listeria monocytogenes is to monitor cell density, we followed Agr expression in batch cultures, in which the autoinducer concentration was uniform, and in biofilms. Expression was heterogeneous, suggesting that the primary function of Agr is not to monitor population density.
Changes in gene expression during adaptation of Listeria monocytogenes to the soil environment
2011
project SEST 009; International audience; Listeria monocytogenes is a ubiquitous opportunistic pathogen responsible for listeriosis. In order to study the processes underlying its ability to adapt to the soil environment, whole-genome arrays were used to analyse transcriptome modifications 15 minutes, 30 minutes and 18 h after inoculation of L. monocytogenes EGD-e in soil extracts. Growth was observed within the first day of incubation and large numbers were still detected in soil extract and soil microcosms one year after the start of the experiment. Major transcriptional reprofiling was observed. Nutrient acquisition mechanisms (phosphoenolpyruvate-dependent phosphotransferase systems and…
Climate change influences on aviation: A literature review
2020
While the aviation sector has long been referenced as contributing to the causes of climate change, the need for aviation to adapt to the consequences of climate change has not been as well researched or considered. The paper is a systematic quantitative literature review on climate change and aviation, which aims to explicate significant issues affecting aviation in a changing climate and to identify the aviation industry responses on climate change and adaptation. There are 46 references involved in the detailed assessment, selected according to variables such as methodology, paper outcomes and industry stakeholder. This emergent aviation and climate change adaptation literature could be …
Analyse morphologique de talwegs et comportement scalant : applications des dimensions non-entières à la géographie physique
1999
Morphological talweg analysis and scaling behaviour: applying non-integer dimension to physical geography. -- The organisation of the talweg network is fundamental to the erosion system on the silty loamy plateaux of north-western France. The morphology of the Pays de Caux is a good example of successive runoff concentration caused by the nesting of small dry valleys. These are inherited from a periglacial climate and their general direction is governed by tectonics. However the detailed pattern of these forms remains complex and without obvious explanation. Non-integer dimensions may offer a ceratin logic to this relatively chaotic pattern. This paper has therefore sought to demonstrate th…
Un approccio mediterraneo: il “ritorno alla campagna” e il ruolo del turismo per le aree interne
2015
La crisi finanziaria globale coinvolge e sconvolge le economie reali e quindi anche i sistemi valoriali alla base delle strumentazioni di governo delle trasformazioni urbane e territoriali stressando le sperimentazioni di governance dei modelli di sviluppo place based a seconda delle tipologie territoriali e dei loro livelli di declino. Il turismo sostenibile sembra inserirsi in modo utile nelle strategie di resilienza dei territori. Nella prima parte si sottolinea il rapporto tra pianificazione territoriale e agricoltura che torna ad essere centrale. Le ICT spingono la condizione sociale a mutare verso quella di cittadini del mondo che vivono lo spazio ed il tempo immergendosi dentro una v…
Territori marginali e finestre di opportunità. Norcia tra gli eventi sismici del 1979 e del 2016
2021
Il contributo intende indagare la stretta connessione tra disastri naturali e traiettorie di sviluppo territoriale e come queste ultime siano determinate in larga parte dalle politiche pubbliche messe in atto nella fase post-emergenziale. A seguito dei disastri, il dibattito pubblico e politico, i grandi investimenti, la possibilità di operare trasformazioni urbanistiche possono generare uno scenario di opportunità e rinascita definibile come «window of opportunity». Si prende qui in considerazione l’evento sismico del 1979 di Norcia, insieme al relativo processo di ricostruzione, avviato assieme a un piano di rinascita economica incentrato sulle vocazioni locali e capace di frenare le tend…