Search results for "Developmental neuroscience"
showing 10 items of 360 documents
Selection into long-term unemployment and its psychological consequences
2000
The factors which predict a person’s long-term unemployment were studied within the framework of an emotional and behavioural regulation model consisting of two orthogonal dimensions: behavioural inhibition versus expression, and low versus high self-control of emotions (Pulkkinen, 1995, 1996). The participants were drawn from the ongoing Jyväskylä Longitudinal Study of Personality and Social Development, in which the same individuals have been followed up from age 8 ( n = 369) to 36 ( n = 311). In the present study, data collected at ages 8, 14, 27, and 36 were used. The findings showed that low self-control of emotions, especially aggression, at age 8 directly predicted long-term unemplo…
Is social capital a mediator between self-control and psychological and social functioning across 34 years
2011
The aim of this study was to investigate the role of social capital assessed in early adulthood in linking self-control in childhood with psychological and social functioning in middle age. Data collected at ages 8, 27, and 42 years were based on the Jyväskylä Longitudinal Study of Personality and Social Development (159 females, 177 males). Self-control was assessed at age 8 using teacher ratings and peer nominations. Social capital at age 27 was operationalized in terms of the breadth of the individuals’ social network and the depth of their close relationships. Psychological functioning at age 42 was indicated by, for instance, psychological well-being, and social functioning was indica…
Longitudinal study on reciprocity between personality traits and parenting stress
2014
Reciprocal associations between the Big Five personality traits and parenting stress—including both parents’ feelings of their distress and perception of their incompetence as parents—were studied with 248 participants (49% of which were males). Longitudinal data, collected at ages 33/36, 42 and 50 years, were used. Cross-lagged path analysis revealed that in case of both mothers and fathers, neuroticism at age 33 predicted high parenting stress, and extraversion at age 33 predicted low parenting stress at age 42. Also, parenting stress at age 36 predicted high neuroticism and low extraversion at age 42. From age 42 to 50, only high parenting stress contributed to low neuroticism. Thus, mo…
Are friends and romantic partners the “best medicine”? How the quality of other close relations mediates the impact of changing family relationships …
2007
In this longitudinal study, the link between changing relationships between adolescents and their parents and the mediating role of friendships and support from romantic partners on internalizing and externalizing symptoms were analyzed. Based on data on parent—child relationships obtained in 228 adolescents (ages 14 to 17) and their fathers and mothers, three different developmental trajectories were found which were differently linked with internalizing and externalizing symptomatology at ages 17 and 21. The quality of relationships with friends and romantic partners mediated the links between earlier parent—adolescent relationships and later problem behavior. The impact of close relation…
Timing of parenthood in relation to other life transitions and adult social functioning
2009
The timing of having one's first child, in relation to the timing of other transitions into adulthood and to social functioning, was investigated based on the Finnish Jyväskylä Longitudinal Study of Personality and Social Development, conducted from age 8 (173 females and 196 males) to 42. Results showed that in women, relatively early (< 25 years) motherhood was associated with the early timing of all studied transitions (move from parental home, intimate relationship, education, full-time job); in men, early fatherhood was associated only with the early start of an intimate relationship. In women, but not in men, early parenthood was linked to a lower level of education, lower occupat…
Immigrant status, gender, and school burnout in Finnish lower secondary school students : A longitudinal study
2017
The aim of this longitudinal study among 9223 students from grade 7 and grade 9 (age 13–14 and 15–16) was to assess whether immigrant status and gender are associated with the level and change (slope) in school burnout among lower secondary school students in the Helsinki metropolitan area. Ninety-seven percent of the variation in school burnout was attributable to individual factors. Both the intercept (2.3, p < 0.001) and slope (0.5, p < 0.001) of school burnout were statistically significant. The slope showed increasing school burnout from grades 7–9. School burnout increased more in girls than in boys. Initially apparent higher school burnout among students who had immigrated to …
Dyslexia—Early Identification and Prevention: Highlights from the Jyväskylä Longitudinal Study of Dyslexia
2015
Over two decades of Finnish research, monitoring children born with risk for dyslexia has been carried out in the Jyvaskyla Longitudinal Study of Dyslexia (JLD). Two hundred children, half at risk, have been assessed from birth to puberty on hundreds of measures. The aims were to identify measures of prediction of later reading difficulty and to instigate appropriate and earliest diagnosis and intervention. We can identify at-risk children from newborn electroencephalographic brain recordings (Guttorm et al., J Neural Transm 110:1059–1074, 2003). Predictors are also apparent from late-talking infants who have familial background of dyslexia (Lyytinen and Lyytinen, Appl Psycolinguistics 25:3…
Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative harm…
2017
Abstract Introduction A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium–Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Methods Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple …
A novel mutation of WDR62 gene associated with severe phenotype including infantile spasm, microcephaly, and intellectual disability
2017
Abstract The autosomal recessive form of primary microcephaly (MCPH) is a rare disorder characterized by head circumference of at least 3 standard deviation below the mean. The MCPH exhibits genetic heterogeneity with thirteen loci (MCPH1-MCPH13) identified, and associated with variable degree of intellectual disability. It has been reported that WDR62 is the second causative gene of autosomal recessive microcephaly (MCPH2) playing a significant role in spindle formation and the proliferation of neuronal progenitor cells. We report a clinical feature, electroclinical findings, and clinical course of a patient with a severe phenotype of MCPH2 including microcephaly, refractory infantile spas…
Pathology-selective antiepileptic effects in the focal freeze-lesion rat model of malformation of cortical development
2021
Malformations of cortical development (MCD) represent a group of rare diseases with severe clinical presentation as epileptic and pharmacoresistant encephalopathies. Morphological studies in tissue from MCD patients have revealed reduced GABAergic efficacy and increased intracellular chloride concentration in neuronal cells as important pathophysiological mechanisms in MCD. Also, in various animal models, alterations of GABAergic inhibition have been postulated as a predominant factor contributing to perilesional hyperexcitability. Along with this line, the NKCC1 inhibitor bumetanide has been postulated as a potential drug for treatment of epilepsy, mediating its antiepileptic effect by red…