Search results for "Digest"
showing 10 items of 3038 documents
Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity : A Multicentre Study
2022
Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) are poorly defined. \ud \ud \ud \ud Objectives: To evaluate the structural and inflammatory features of NCGS compared to controls and coeliac disease (CeD) with milder enteropathy (Marsh I-II). \ud \ud \ud \ud Methods: Well-oriented biopsies of 262 control cases with normal gastroscopy and histologic findings, 261 CeD, and 175 NCGS biopsies from 9 contributing countries were examined. Villus height (VH, in μm), crypt depth (CrD, in μm), villus-to-crypt ratios (VCR), IELs (intraepithelial lymphocytes/100 enterocytes), and other relevant histological, serologic, and…
Effect of micro-aeration and leachate replacement on COD solubilization and VFA production during mono-digestion of grass-silage in one-stage leach-b…
2010
The effect of micro-aeration and leachate replacement with fresh water on chemical oxygen demand (COD) solubilization and volatile fatty acid (VFA) production during the mono-digestion of grass-silage in one-stage leach-bed reactors (LBRs) was investigated in four LBRs, L0 (control), L1, L2 and L3 in batch mode at 35 + or - 1 degrees Celsius for 57 days. Results showed that leachate replacement without pH adjustment (L3) resulted in 2.7 and 1.3 times more SCOD in the leachate compared to control (L0) or leachate replacement with initial pH adjustment (L1), respectively. Micro-aeration at flow rate of 1 L min(-1) (2.5 L of air) in L2 resulted in 4-fold increase in VFA production (from 2.2 to…
Co-digestion of grass silage and cow manure in a CSTR by re-circulation of alkali treated solids of the digestate.
2008
Three laboratory, continuously stirred tank reactors (CSTRs) co-digesting grass silage and cow manure (forming 30% and 70% of substrate volatile solids (VS), respectively) were operated to evaluate the effects of re-circulating an alkali-treated and untreated solid fraction of the digestate back to the reactors. The CSTRs were operated at an organic loading rate (OLR) of 2 kg VS m(-3) day(-1) and hydraulic retention time (HRT) of 20 days with a semi-continuous mode of feeding. The feasibility of co-digestion with substrate VS containing 30% VS of crop was reinforced, resulting in average specific methane yield of about 180-185 1 CH4 kg(-1) VS. Re-circulation of the solid fraction of digesta…
Organic silicon compounds in biogases produced from grass silage, grass and maize in laboratory batch assays
2013
Abstract In the present study the occurrence of volatile organic silicon compounds in biogas produced from grass silage, grass and maize in laboratory batch assays was analyzed and methane potentials were determined. Inoculum from a mesophilic farm digester was used, and its effects were subtracted. Methane yields from grass silage, grass and maize were 0.38, 0.42 and 0.34 m3CH4/kg – volatile solids added (VSadd), respectively. Trimethyl silanol, hexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) were detected from all the biogases. Higher yields of volatile organic silicon compounds in the grass (from 21.8 to 37.6 μg/kgVSadd) were detec…
Effect of macro and micro nutrients addition during anaerobic mono-digestion of grass silage in leach-bed reactors
2019
The effect of macro- (NH4Cl) (set I) and micro-nutrients (Fe, Ni, Co and Mo) (set II) addition on chemical oxygen demand (COD) solubilisation during anaerobic mono-digestion of grass silage was investigated in two sets of leach bed reactor experiments at 35°C. Results showed that addition of NH4Cl and micro-nutrients improved COD solubilisation by 18% (0.56 g SCOD g−1 volatile solids) and 7% (0.45 g SCOD g−1 VS), respectively than control. About 20–50% of the added micro-nutrients were bioavailable in the produced leachates, while the rest (50–80%) were adsorbed onto the grass silage. Results of biological methane potential assays showed that, specific methane yields of grass silage were im…
Degradation of silica particles functionalised with essential oil components under simulated physiological conditions
2020
[EN] In this work, the biodurability of three silica particle types (synthetic amourphous silica, MCM-41 microparticles, MCM-41 nanoparticles) functionalised with three different essential oil components (carvacrol, eugenol, vanillin) was studied under conditions that represented the human gastrointestinal tract and lysosomal fluid. The effect of particle type, surface immobilised component and mass quantity on the physico-chemical properties of particles and silicon dissolution was determined. Exposure to biological fluids did not bring about changes in the zeta potential values or particle size distribution of the bare or functionalised materials, but the in vitro digestion process partia…
Ultrasensitive Silicon Nanowire for Real-World Gas Sensing: Noninvasive Diagnosis of Cancer from Breath Volatolome
2014
We report on an ultrasensitive, molecularly modified silicon nanowire field effect transistor that brings together the lock-and-key and cross-reactive sensing worlds for the diagnosis of (gastric) cancer from exhaled volatolome. The sensor is able to selectively detect volatile organic compounds (VOCs) that are linked with gastric cancer conditions in exhaled breath and to discriminate them from environmental VOCs that exist in exhaled breath samples but do not relate to the gastric cancer per se. Using breath samples collected from actual patients with gastric cancer and from volunteers who do not have cancer, blind analysis validated the ability of the reported sensor to discriminate betw…
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1)…
2014
Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus ribavirin has improved sustained virological response (SVR) in treatment-naive and treatment-experienced patients infected with hepatitis C virus (HCV) genotype 1, the regimens have a high pill burden and are associated with increased rates and severity of adverse events, such as anaemia and rash. The efficacy and safety of the combination of simeprevir, a one pill, once-daily, oral HCV NS3/4A protease inhibitor, plus peginterferon alfa 2a plus ribavirin were assessed in treatment-naive patients with HCV genotype 1 infection.In QUEST-1, a phase 3, randomise…
Efficacy of a 12-Week Simeprevir Plus Peginterferon/Ribavirin (PR) Regimen in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 4 (GT4) …
2017
Background HCV GT4 accounts for up to 20% of HCV infections worldwide. Simeprevir, given for 12 weeks as part of a 24- or 48-week combination regimen with PR is approved for the treatment of chronic HCV GT4 infection. Primary study objectives were assessment of efficacy and safety of simeprevir plus PR in treatment-naïve patients with HCV GT4 treated for 12 weeks. Primary efficacy outcome was sustained virologic response 12 weeks post-treatment (SVR12). Additional objectives included investigation of potential associations of rapid virologic response and baseline factors with SVR12. Methods This multicentre, open-label, single-arm study (NCT01846832) evaluated efficacy and safety of simepre…
Biological Nutrient Removal Model No. 2 (BNRM2): a general model for wastewater treatment plants
2013
This paper presents the plant-wide model Biological Nutrient Removal Model No. 2 (BNRM2). Since nitrite was not considered in the BNRM1, and this previous model also failed to accurately simulate the anaerobic digestion because precipitation processes were not considered, an extension of BNRM1 has been developed. This extension comprises all the components and processes required to simulate nitrogen removal via nitrite and the formation of the solids most likely to precipitate in anaerobic digesters. The solids considered in BNRM2 are: struvite, amorphous calcium phosphate, hidroxyapatite, newberite, vivianite, strengite, variscite, and calcium carbonate. With regard to nitrogen removal via…