Search results for "Dimension"

showing 10 items of 2766 documents

Antiproliferative Oleanane Saponins from Meryta denhamii

2008

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

StereochemistrySaponinPharmaceutical SciencePharmacognosyAnalytical ChemistryMicechemistry.chemical_compoundTriterpeneDrug DiscoveryAnimalsHumansMeryta denhamiiOleanolic AcidAraliaceaeNuclear Magnetic Resonance BiomolecularOleananePharmacologychemistry.chemical_classificationPlants MedicinalMolecular StructurebiologyOrganic ChemistryGlycosideSaponinsbiology.organism_classificationAntineoplastic Agents PhytogenicSettore CHIM/08 - Chimica FarmaceuticaOleanane Saponins Antiproliferative effectsTerpenoidItalyComplementary and alternative medicinechemistryBiochemistrySettore BIO/14 - FarmacologiaMolecular MedicineDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyJournal of Natural Products
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Steroidal saponins from Chlorophytum orchidastrum.

2009

Six new spirostane-type saponins (1−6), named orchidastrosides A−F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1−6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.

Stereochemistrymedicine.medical_treatmentChemical structureSaponinPharmaceutical SciencePharmacognosyPlant RootsAnalytical ChemistrySteroidchemistry.chemical_compoundDrug DiscoverymedicineLiliaceaeSpirostansHumansPharmacologychemistry.chemical_classificationMolecular StructureOrganic ChemistryAcetalGlycosideOligosaccharideSaponinsHCT116 CellsAntineoplastic Agents PhytogenicComplementary and alternative medicinechemistryMolecular MedicineFranceDrug Screening Assays AntitumorTwo-dimensional nuclear magnetic resonance spectroscopyHT29 CellsJournal of natural products
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The Importance of Electronic Dimensionality in Multiorbital Radical Conductors.

2019

The exceptional performance of oxobenzene-bridged bis-1,2,3-dithiazolyls 6 as single-component neutral radical conductors arises from the presence of a low-lying π-lowest unoccupied molecular orbital, which reduces the potential barrier to charge transport and increases the kinetic stabilization energy of the metallic state. As part of ongoing efforts to modify the solid-state structures and transport properties of these so-called multiorbital materials, we report the preparation and characterization of the acetoxy, methoxy, and thiomethyl derivatives 6 (R = OAc, OMe, SMe). The crystal structures are based on ribbonlike arrays of radicals laced together by S···N' and S···O' secondary bondin…

Steric effects010405 organic chemistryChemistryRadicalElectronic structureCrystal structuremultiorbital radical conductors010402 general chemistryvapaat radikaalitkiteet01 natural sciencessähkönjohtavuus0104 chemical sciencesInorganic ChemistryCrystallographyelectronic dimensionalityElectronic effectAntiferromagnetismMolecular orbitalDensity functional theoryPhysical and Theoretical Chemistryta116Inorganic chemistry
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Ligand effects on the dimensionality of oxamato-bridged mixed-metal open-framework magnets

2012

Increasing dimensionality [from 2D (1) to 3D (2)] and T(C) [from 10 (1) to 20 K (2)] in two new oxamato-bridged heterobimetallic Mn(II)(2)Cu(II)(3) open-frameworks result from the steric hindrance provided by the different alkyl substituents of the N-phenyloxamate bridging ligands.

Steric effectschemistry.chemical_classificationBridging (networking)Mixed metalChemistryLigandStereochemistryMetals and AlloysGeneral ChemistryOpen frameworkCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCrystallographyMagnetMaterials ChemistryCeramics and CompositesAlkylCurse of dimensionalityChemical Communications
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Stochastic algorithms for robust statistics in high dimension

2016

This thesis focus on stochastic algorithms in high dimension as well as their application in robust statistics. In what follows, the expression high dimension may be used when the the size of the studied sample is large or when the variables we consider take values in high dimensional spaces (not necessarily finite). In order to analyze these kind of data, it can be interesting to consider algorithms which are fast, which do not need to store all the data, and which allow to update easily the estimates. In large sample of high dimensional data, outliers detection is often complicated. Nevertheless, these outliers, even if they are not many, can strongly disturb simple indicators like the me…

Stochastic AlgorithmsAlgorithmes StochastiquesAlgorithmes RécursifsRecursive AlgorithmsStatistique RobusteAlgorithmes de Gradient StochastiquesAveragingStochastic Gradient AlgorithmsMoyennisationGrande DimensionRobust StatisticsFunctional DataDonnées Fonctionnelles[MATH.MATH-ST] Mathematics [math]/Statistics [math.ST]Geometric MedianHigh DimensionMédiane Géométrique
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A Fokker–Planck control framework for multidimensional stochastic processes

2013

AbstractAn efficient framework for the optimal control of probability density functions (PDFs) of multidimensional stochastic processes is presented. This framework is based on the Fokker–Planck equation that governs the time evolution of the PDF of stochastic processes and on tracking objectives of terminal configuration of the desired PDF. The corresponding optimization problems are formulated as a sequence of open-loop optimality systems in a receding-horizon control strategy. Many theoretical results concerning the forward and the optimal control problem are provided. In particular, it is shown that under appropriate assumptions the open-loop bilinear control function is unique. The res…

Stochastic controlMathematical optimizationContinuous-time stochastic processOptimization problemoptimal control stochastic processesStochastic processApplied MathematicsOptimal controlComputational MathematicsModel predictive controlMultidimensional stochastic processOptimal control theoryLimit cycleProbability density functionFokker–Planck equationFokker–Planck equationModel predictive controlMathematicsJournal of Computational and Applied Mathematics
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Pianificazione strategica tra sviluppo locale e policentrismo: alcune evidenze empiriche sul caso siciliano

2009

Strategic planning, local development and policentrism: empirical evidence for Sicily The aim of this paper is the analysis of metropolitan strategic planning in Sicily. Urban areas are becoming important units for territorial cohesion policy and strategic planning represents more and more an important policy instrument. Evidence of a policentric pattern is tested across 30 strategic plans carried out by Sicilian cities in order to derive useful insights for policy implications. Methods and Results This study uses multidimensional scaling and rank-size regressions across Sicilian Functional Urban Areas (FUA) as well as descriptive information drawn from strategic plans in order to identify …

Strategic planningLocal DevelopmentLocale (computer software)Metropolitan arealanguage.human_languagepolicentrismo pianificazione strategica sviluppo localeGeographyOrder (exchange)Regional sciencelanguageGeneral Earth and Planetary SciencesOperations managementMultidimensional scalingEmpirical evidenceSicilianGeneral Environmental Science
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Functionalized lipid tubules as tools for helical crystallization of proteins

1997

The development of functional supramolecular devices built by self-assembly of elementary molecules and with bioactive properties arouses considerable interest in the field of nanotechnology and new materials. We report here the formation of a new class of lipid tubules exhibiting both properties of molecular recognition and crystal formation for the protein streptavidin. These lipid tubules, made of biotin-containing dioctadecylamine molecules, are straight hollow cylinders with a constant diameter of 27 nm and variable length up to several micrometers. They are unilamellar with an inner diameter of about 16 nm, as shown by cryoelectron microscopy. Streptavidin binds to the biotinylated tu…

StreptavidinliposomesSupramolecular chemistryTWO-DIMENSIONAL CRYSTALSMEMBRANESCatalysisACETYLCHOLINE-RECEPTORVESICLESlipidschemistry.chemical_compoundTOXIN B-SUBUNITMolecular recognition2-DIMENSIONAL CRYSTALLIZATIONELECTRON-MICROSCOPYLiposomeChemistryVesicleOrganic Chemistrytechnology industry and agricultureCHOLERA-TOXINGeneral ChemistryCrystallographyMembranehelical structuresRESOLUTIONBiotinylationSelf-assemblyself-assembly tubulesMICROSTRUCTURESChemistry – A European Journal
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Against Metaphysical Structuralism

2020

Abstract Inductive Metaphysics (IM) combines an anti-aprioristic emphasis on an empirical and scientific basis for metaphysics with an insistence on a specifically philosophical abductive theory-building. Since the latter specifically philosophical work is not empirical itself, it may in a liberal sense be called apriori. This paper highlights this apriori dimension within IM by a case study on Structuralism, the view that fundamental reality consists of a network of relations (and properties), which a number of philosophers consider to be suggested by modern physics. Focussing on Dasgupta’s algebraic Generalism, the author argues that Structuralism suffers from a severe entailment problem,…

Structuralism (biology)PhilosophyPhilosophyMetaphysicsA priori and a posterioriDimension (data warehouse)EpistemologyGrazer Philosophische Studien
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Elaboration of a Critical Paradigm for Interpreting Modern Architecture: The Almost Intangible Essence of Luigi Moretti's Casa del Balilla at Trecate

2021

Modern architecture is not, from a lexical point of view, uniquely definable. The heterogeneity of the twentieth century heritage is therefore a collective wealth that should be protected from the risk of falling into oblivion. In order to avoid this, it could prove fundamental to establish a process of the knowledge of these assets. This should not, however, result in a simple and passive recording of architectural facts: a deep understanding of the complexity of modern architecture, which has as its objective the protection of buildings, could be obtained, for example, through a real and proper decoding of signs, conducted by a critical use of the metalanguage most congenial to the archit…

Structure (mathematical logic)Point (typography)Process (engineering)Computer scienceDrawingMetalanguageLuigi MorettiRepresentation (arts)LexiconEpistemologyTamperingSettore ICAR/17 - DisegnoGraphic analysiArchitectureThree-dimensional modelingModern architectureSimple (philosophy)
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