Search results for "Dios"
showing 10 items of 1322 documents
Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy
2012
A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer c…
2013
The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging have been developed. To some extent, they all lack the optimal balance between efficient radiochemistry and favorable in vivo characteristics. A new clickable olate precursor was synthesized by regioselective coupling of folic acid to 11-azido-3,6,9-trioxaundecan-1-amine at the γ-position of the glutamic acid residue. The non-radioactive reference compound was synthesized via copper-catalyzed azide-alkyne cycloaddition of 3-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)prop-1-yne and γ-(11-azid…
The value of serial MR imaging in the assessment of brain metastases volume control during stereotactic radiosurgery
2015
Purpose: To evaluate early tumour control capabilities of Stereotactic Radiosurgery (SRS) in the treatment of brain metastasis and the role of follow-up MR imaging. Methods and Materials: MR imaging of 54 metastases in 31 patients treated with SRS who underwent follow-up MR imaging within 12 months were retrospectively reviewed. Tumours were characterized as either enlarged (>20% volume increase), stable (follow-up volume ±20% of the initial volume), or decreased (> 0% volume decrease). Results: Within the first 6 weeks following SRS a decrease was observed in 25 (52%) of the tumours in the extent of 63% in size. Tumour reduction varied according to histopathological subtype with 38% of non…
Stereotactic Radiosurgery of Deeply Seated Low Grade Gliomas
1994
The authors report the results of a series of 16 cases of low-grade gliomas in whom radiosurgery was performed. This series started in 1977. All the tumours received a single radiosurgical session (with a mean dose of 21.7 Gy, 5–10mm. collimator; one patient received two sessions and in another patient two different targets were irradiated in the same session). Prior to radiosurgery, six patients received conventional external fractionated radiotherapy, with two lateral fields of up to 10 × 10 cm. and a mean dose of 55.1 Gy. and another six patients with tumours less than 5 cm. in diameter, received stereotactic radiotherapy using four fields of up to 5 × 5 cm. and a mean dose of 53.1 Gy. I…
Partial least squares modelization of energy dispersive X-ray fluorescence.
2019
As a proof of concept, a green methodology has been developed for the energy dispersive X-ray fluorescence (ED-XRF) determination of calcium, potassium, iron, magnesium, aluminum, chromium, strontium, phosphorus and nickel in the peel of untreated kaki fruit (Diospyros kaki. L) samples. ED-XRF spectra of fifty-six kakis purchased in the local area of LLombay (Valencia) were obtained directly from samples without any previous treatment and without sample damage just after cleaning the fruit with distilled water. Inductively Couple Plasma Optical Emission Spectrometry (ICP-OES) was used as a reference method to determine the mineral elements after microwave assisted acid digestion. XRF spectr…
Surface temperature and water vapour retrieval from MODIS data
2003
This paper gives operational algorithms for retrieving sea (SST), land surface temperature (LST) and total atmospheric water vapour content (W) using Moderate Resolution Imaging Spectroradiometer (MODIS) data. To this end, the MODTRAN 3.5 radiative transfer program was used to predict radiances for MODIS channels 31, 32, 2, 17, 18 and 19. To analyse atmospheric effects, a simulation with a set of radiosonde observations was used to cover the variability of surface temperature and water vapour concentration on a worldwide scale. These simulated data were split into two sets (DB1 and DB2), the first one (DB1) was used to fit the coefficients of the algorithms, while the second one (DB2) was u…
The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome
2020
© 2020 by the authors.
Host immune response to Cryptosporidium parvum infection
2010
Species of the genus Cryptosporidium are protozoan parasites (Apicomplexa) that cause gastroenteritis in animals and humans. Of these Cryptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a chronic, life-threatening disease. As specific therapeutic or preventive interventions are not yet available, better understanding of the immune response to the parasite is required. This minireview briefly summarizes the factors involved in the innate and acquired immune response in this pathogen-host interaction with an emphasis on more recent da…
Análisis de materiales didácticos digitales ofertados por la industria editorial
2018
Los materiales educativos han sufrido cambios importantes que afectan a elementos de la práctica educativa: organizativos, metodológicos... La inclusión de las tecnologías en los centros ha favorecido el desarrollo de nuevos formatos que permiten la transición del libro de texto tradicional a una diversidad de materiales digitales. En este trabajo presentamos un estudio que analiza las características pedagógicas y tecnológicas de una muestra de materiales didácticos digitales en niveles valencianos de primaria. Estudio que forma parte de uno más amplio y que incluye a grupos de investigación de Canarias y Galicia. De los resultados señalamos que los analizados de editoriales educativas ofr…
Los Estudios Culturales en el panorama de la investigación pedagógica de las TIC. ¿Una apuesta oportuna?
2007
Actualmente son muchos y de diversa naturaleza los documentos que están apareciendo sobre la utilización de TIC en la institución escolar, aunque nos preguntamos cuáles de ellos profundizan realmente en cómo se está llevando a cabo dicha integración y cómo mejorarla. Analizando una muestra de ellos, concluimos que muchos no van más allá de informaciones como el número de aparatos en las aulas o el porcentaje de centros con conexión a Internet. Por ello, y en aras de obtener una mirada holista, apostamos por los Estudios Culturales (EC) como perspectiva interdisciplinar necesaria en el acercamiento a este tema.