Search results for "Disorders"
showing 10 items of 4560 documents
Update on intravitreal anti-tumor necrosis factor alpha therapies for ocular disorders
2014
Abstract Tumor necrosis factor alpha (TNF-?) is an important pro-inflammatory cytokine associated with a variety of ocular diseases. The currently available TNF-? inhibitors are etanercept, infliximab, adalimumab, golimumab, and certolizumab. Experimental and clinical studies on the intravitreal use of these agents have been reported with etanercept, infliximab, and adalimumab: etanercept has shown limited efficacy in scarce reports; infliximab has been associated with local safety concerns but appears to benefit certain cases; adalimumab has shown no efficacy in cases of age-related macular degeneration (AMD) or diabetic macular edema (DME), but the combination with bevacizumab may be effe…
Frequency and Correlates of Mild Cognitive Impairment in Myasthenia Gravis
2023
Background: Antibodies against acetylcholine receptors (AChRs) can also target nicotinic AChRs that are present throughout the central nervous system, thus leading to cognitive dysfunctions in patients with myasthenia gravis (MG). However, the presence of cognitive impairment in MG is controversial, and the factors that may influence this risk are almost completely unknown. In this study, the frequency of mild cognitive impairment (MCI) in MG, as well as the clinical, immunological, and behavioral correlates of MCI in MG were evaluated. Methods: A total of 52 patients with MG underwent a comprehensive assessment including motor and functional scales, serological testing, and neuropsychologi…
Poznawczo-behawioralne programy terapeutyczne wykorzystywane w pracy z wymagającymi wsparcia adolescentami z zaburzeniami ze spektrum autyzmu (ASD L1…
2020
Artykuł zawiera opis wybranych metod poznawczo-behawioralnych wykorzystywanych w pracy z wymagającą wsparcia młodzieżą z zaburzeniami ze spektrum autyzmu (ASD L1). We wstępie opisano pokrótce historię zaburzenia i podstawowe problemy występujące u dzieci i młodzieży ze spektrum zaburzeń autystycznych. W dalszej części przytoczono informacje na temat technik poznawczo-behawioralnych często stosowanych w pracy z tymi adolescentami. Omówiono przykładowe programy treningów umiejętności społecznych: PEERS (Program for the Education and Enrichment of Relationship Skills) oraz MASSI (Multimodal Anxiety and Social Skills Intervention). Przybliżono dwa programy wykorzystywane w pracy nad rozwijaniem…
Eating behaviours, menstrual history and the athletic career: a retrospective survey from adolescence to adulthood in female endurance athletes
2023
AimTo evaluate differences in menstrual and pubertal history and trends in eating behaviours among women with and without a competitive sports background. Additionally, we investigated if menstrual history and eating behaviours are associated with sports career-related factors.MethodsThis retrospective study was conducted on 100 women with a competitive endurance sports background and their age-matched, gender-matched and municipality-matched controls (n=98). Data were collected using a questionnaire using previously validated instruments. Generalised estimating equations were used to calculate associations of menstrual history and eating behaviours with outcome variables (career length, pa…
Communicative skills in Spanish children with Autism Spectrum Disorder and children with Attention Deficit Hyperactivity Disorder. Analysis through p…
2018
Background Communicative skills are one of the main deficits experienced by children with Autism Spectrum Disorder (ASD). The differential diagnosis is a complex issue that clinicians often face. For this reason, this study has two objectives: 1) to analyze the similarities and differences that children with Attention Deficit Hyperactivity Disorder (ADHD) and children with ASD present in their linguistic and communicative skills, through parentś perceptions and narrative production; 2) to identify the relative importance of the skills analyzed in discriminating children with ASD versus children with ADHD, as well as the classification power of each of the two measurement methods used. Metho…
Gendered positioning: Addressing gendered power and cultural discourses in therapeutic conversations
2016
This research examined gendered positioning in therapeutic conversations, especially in treatment of intimate partner violence (IPV). A feminist-informed reading combined with a discursive psychological approach was applied in three studies on positioning in therapeutic conversations. This reading focused on gendered positioning, gendered power and cultural discourses. Thus, the aim of this research was to examine how gender is constructed in therapeutic conversations that deal with couple relationship issues, and how the power distribution this entails is addressed in these conversations. The data consisted of videotaped and transcribed couple therapy sessions and group treatment sessions …
Selected needling techniques in pain associated with musculoskeletal disorders: a narrative review
2022
Background: Therapies involving various needling techniques are becoming more common treatment methods for musculoskeletal disorders. Aim of the study: To review the most commonly used needling techniques and their effect on the level of pain and functional status of patients with selected musculoskeletal disorders, i.e., lower back pain, upper trapezius muscle (UT) pain, cervicogenic headaches, myofascial pain syndrome (MPS), and chronic pain localized to the knee joint. Material and methods: A review of the academic literature was conducted between December 2021 and January 2022. The needle therapy methods used in the treatment of pain ailments were selected based on publications availabl…
Stick around: Cell–Cell Adhesion Molecules during Neocortical Development
2021
The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classi…
Polymer Drug Conjugates for the Treatment of Neurodegenerative Disorders
2013
Nanociencia y nanotecnología son la base de técnicas innovadoras para el transporte de fármacos con beneficios potenciales para el paciente y nuevos mercados para la industria. La obtención de nuevos sistemas de transporte de fármacos más efectivos es uno de los principales retos actuales, junto con la mejora del diagnóstico tanto in vitro como in vivo y el desarrollo de tecnologías para la ingeniería tisular y la medicina regenerativa. Además de ser necesario disponer de moléculas con actividad farmacológica para conseguir terapias efectivas se necesitan su transporte y liberación controlada para llegar a conseguir tratamientos con mayor índice terapéutico. El uso de estrategias de direcci…
Cranio-Facial Characteristics in Children with Autism Spectrum Disorders (ASD)
2019
Background: Cranio-facial anomalies frequently occur in neurodevelopmental disorders because both face and brain are derived from neuroectoderm. The identification of differences in the facial phenotype of children with Autism Spectrum Disorders (ASD) may reflect alterations in embryologic brain development in children with ASD. Methods: we evaluated 33 caucasian children with ASD using a 2D computerized photogrammetry. Anthropometric euclidean measurements and landmarks located on the soft tissue of the face and head, were based on five cranio-facial indexes. Relationships between anthropometric z-scores and participant characteristics (i.e., age, Global IQ, severity of autistic symptoms m…