Search results for "Diss"
showing 10 items of 2500 documents
Dissipativity-Based Small-Gain Theorems for Stochastic Network Systems
2016
In this paper, some small-gain theorems are proposed for stochastic network systems which describe large-scale systems with interconnections, uncertainties and random disturbances. By the aid of conditional dissipativity and showing times of stochastic interval, small-gain conditions proposed for the deterministic case are extended to the stochastic case. When some design parameters are tunable in practice, we invaginate a simpler method to verify small-gain condition by selecting one subsystem as a monitor. Compared with the existing results, the existence-and-uniqueness of solution and ultimate uniform boundedness of input are removed from requirements of input-to-state stability and smal…
Efficient Protection for VDI Workstations
2019
Many enterprises migrate to a private cloud VDI environment. In such an environment multiple workstations are served by a single powerful server. On such an environment each VDI workstation receives only a limited CPU power. An average of less than a quarter of a core per planned VDI workstation is a common setup. Under such cases, anti-virus and application control software load is multiplied by the number of VDI workstation running on each server. These security applications take merely a few percentages of a single core on a normal desktop. However, on a VDI server where the multiple VDI workstations run on a single server, they may consume 20-25 percent the load. Naturally, such an incr…
Seismic behavior of structures equipped with variable friction dissipative (VFD) systems
2021
Usually, to mitigate the stresses in framed structures, different strategies are used. Among them, base isolation, viscous/friction/metallic yielding dampers and tuned mass dumpers have been widely investigated. Fluid Viscous Dampers (FVD) probably result the most diffused for the simplicity in the applications. However, these type of dampers request limited interstorey drifts to avoid dangerous effects. Further, they have an elevate cost. On the contrary, friction dampers are not so expensive but request high interstorey drifts to give a significant contribute in the dissipation of energy during an earthquake. In this paper an approach for the energy dissipation by friction, modified with …
Biological and physical modification of carbonate system parameters along the salinity gradient in shallow hypersaline solar salterns in Trapani, Ita…
2017
Abstract We investigated changes in the chemical characteristics of evaporating seawater under the influence of microbial activity by conducting geochemical analyses of the brines and evaporite sediments collected from solar salterns in Trapani, Italy. The microbial activity had a substantial effect on the carbonate system parameters. Dissolved inorganic carbon (DIC) was substantially removed from the brine during the course of evaporation from the seawater to the point where calcium carbonate precipitates, with an accompanying decrease in its carbon isotopic composition (δ 13 C DIC ) to as low as −10.6‰. Although the removal of DIC was due to calcium carbonate precipitation, photosynthesis…
Overview of the History of the Cranial Nerves: From Galen to the 21st Century
2018
Throughout history the description and classification of the cranial nerves has been linked to the development and characteristics of anatomy and the role that it played as a tool in providing rationality to medicine, together with social, cultural, religious, and philosophical factors. Anatomists were interested in the cranial nerves, but they disagreed on their number and their paths. We can divide the history of the cranial nerves into three different periods: the first, early or macroscopic period; the second or microscopic period; and the third period or ontogenesis and genoarchitecture. The main aim of this article is to show how the description and knowledge of the cranial nerves wer…
TReND in Africa: Toward a Truly Global (Neuro)science Community
2020
TReND is a volunteer-scientist run charity dedicated to promoting research and education on the African continent. Focusing on neuroscience, we discuss approaches to address some of the factors that currently stifle Africa's scientific development and our experience in implementing them.
Trifluoroethanol modulates α-synuclein amyloid-like aggregate formation, stability and dissolution
2016
The conversion of proteins into amyloid fibrils and other amyloid-like aggregates is closely connected to the onset of a series of age-related pathologies. Upon changes in environmental conditions, amyloid-like aggregates may also undergo disassembly into oligomeric aggregates, the latter being recognized as key effectors in toxicity. This indicates new possible routes for in vivo accumulation of toxic species. In the light of the recognized implication of α-Synuclein (αSN) in Parkinson's disease, we present an experimental study on supramolecular assembly of αSN with a focus on stability and disassembly paths of such supramolecular aggregate species. Using spectroscopic techniques, two-pho…
Genotyping and Antifungal Susceptibility of Dipodascus capitatus Isolated in a Neonatal Intensive Care Unit of a Sicilian Hospital
2017
In August 2015, Dipodascus capitatus was isolated from two patients admitted to the neonatal intensive care unit. Nosocomial acquisition of the fungus was suspected and epidemiological studies were undertaken. The patients were simultaneously hospitalized, and the comparison of the two isolates by two independent molecular typing methods have confirmed clonal dissemination of a single strain of D. capitatus. Antimicrobial susceptibility testing was useful for identifying the appropriated antifungal therapy in micafungin. To our knowledge these are the first described cases of neonatal D. capitatus infection and also the first report of successful treatment by micafungin.
Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin.
2017
A single high-affinity fatty acid binding site in the important human transport protein serum albumin (HSA) is identified and characterized using an NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-C12 fatty acid. This ligand exhibits a 1:1 binding stoichiometry in its HSA complex with high site-specificity. The complex dissociation constant is determined by titration experiments as well as radioactive equilibrium dialysis. Competition experiments with the known HSA-binding drugs warfarin and ibuprofen confirm the new binding site to be different from Sudlow-sites I and II. These binding studies are extended to other albumin binders and fatty acid derivatives. Furthermore an X-ray crystal structure …
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …