Search results for "Dynamic"

Le alleanze strategiche quali percorsi di creazione di valore: un’indagine qualitativa sulle alliance evolution capabilities

2012

Thermodynamics and kinetics of ion permeation in wild-type and mutated open active conformation of the human α7 nicotinic receptor

2020

Molecular studies of human pentameric ligand-gated ion channels (LGICs) expressed in neurons and at neuromuscular junctions are of utmost importance in the development of therapeutic strategies for neurological disorders. We focus here on the nicotinic acetylcholine receptor nAChR-α7, a homopentameric channel widely expressed in the human brain, with a proven role in a wide spectrum of disorders including schizophrenia and Alzheimer's disease. By exploiting an all-atom structural model of the full (transmembrane and extracellular) protein in the open, agonist-bound conformation we recently developed, we evaluate the free energy and the mean first passage time of single-ion permeation using …

Utilisation de la Dominance temporelle des sensations pour la caractérisation sensorielle des produits de la filière blé-farine-pain

2012

Eurogerm is specialized in flour correctors, bread improvers and technological ingredients for the wheat, flour and bread sector. The company gives great importance to sensory analysis as a diagnostic tool of finished products and has four expert panels; each panel is specialized in one category of products and is trained to standard sensory profiling. Today, in addition to the traditional method, Eurogerm wants to explore new methods in order to offer new services to its customers. This paper describes the development of Temporal Dominance of Sensations (TDS) created in the “Centre des Sciences du Goût et de l’Alimentation” (CSGA) (PINEAU et al., 2009). TDS provides information on the perc…

Dynamics of the ligand-binding domains of ionotropic glutamate receptors

2010

Spatio-Temporal Effects of Land Use Change on the Anthropogenic Soils Diffusion: A Case Study in a Mediterranean Vineyard Area

2008

Anthropogenic soils created ex novo by land-use change in large scale farming are, from a pedogenetic point of view, catastrophic events that bring the soils to time zero and change the natural pattern of the soilscape, remarkably, in some cases. The quantitative aspects of pedodiversity of a soilscape in South-East Sicily, where some types of soils, in recent decades, have suffered a consistent reduction due to the transformations by large scale farming, are considered. The evolution of pedodiversity over a 53-year period (1955 to 2008) is examined using a dedicated statistical method and a space–time model based on Markov analysis and cellular automata in order to predict the evolution of…

Photocatalytic activity of N-doped TiO2-based materials embedded with gold NPs for applications in antibacterial photodynamic therapy (aPDT)

Antibacterial photodynamic therapy (aPDT) is a potential treatment for antibiotic-resistant bacterial infections. It is based on the photosensitization of bacterial cells with exogenous agents that, when exposed to light, produce reactive oxygen species (ROS), such as OH-, O2-, H2O2. ROS can induce complex oxidative-reductive chains of reactions, resulting in damage of cellular components in target tissues1. Photocatalysts, like inorganic semiconductor oxides, represent an interesting class of materials to design new strategies for aPTD. As exposed to light of proper wavelengths, photocatalysts induce the formation of electron-hole pairs capable of producing a cascade of reactions suitable …

Targeting G-quadruplexes with Organic Dyes: Chelerythrine–DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

2019

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences&mdash

A synthetic derivative of antimicrobial peptide holothuroidin 2 from mediterranean sea cucumber (Holothuria tubulosa) in the control of Listeria mono…

2019

Due to the limited number of available antibiotics, antimicrobial peptides (AMPs) are considered antimicrobial candidates to fight difficult-to-treat infections such as those associated with biofilms. Marine environments are precious sources of AMPs, as shown by the recent discovery of antibiofilm properties of Holothuroidin 2 (H2), an AMP produced by the Mediterranean sea cucumber Holothuria tubulosa. In this study, we considered the properties of a new H2 derivative, named H2d, and we tested it against seven strains of the dangerous foodborne pathogen Listeria monocytogenes. This peptide was more active than H2 in inhibiting the growth of planktonic L. monocytogenes and was able to interf…

Antioxidative and Photo-Induced Effects of Different Types of N-Doped Graphene Quantum Dots.

2022

Due to the increasing number of bacterial infections and the development of resistivity toward antibiotics, new materials and approaches for treatments must be urgently developed. The production of new materials should be ecologically friendly considering overall pollution with chemicals and economically acceptable and accessible to the wide population. Thus, the possibility of using biocompatible graphene quantum dots (GQDs) as an agent in photodynamic therapy was studied. First, dots were obtained using electrochemical cutting of graphite. In only one synthetic step using gamma irradiation, GQDs were doped with N atoms without any reagent. Obtained dots showed blue photoluminescence, with…

Ascending Aorta Resection and End-to-End Anastomosis: Redistribution of Wall Shear Stress Induced by a Bioprosthetic Heart Valve

2020

Although aortic resection and end-to-end anastomosis are applied to repair ascending aortic aneurysm, there is a lack of information on the late risk of post-operative complications, such as aortic dissection and aneurysmal re-dilatation. It is recognized that altered hemodynamic forces exerted on an aortic wall play an important role on dissection and aneurysm formation. We present a case in which the hemodynamic forces were investigated prior and after repair of an ascending aorta treated by resection with end-to-end anastomosis and a bioprosthetic heart valve. Post-operative wall shear stress was redistributed uniformly along the vessel circumference, and this may suggest a reduced risk …