Search results for "ECL"
showing 10 items of 1262 documents
Data from: Propagule pressure increase and phylogenetic diversity decrease community’s susceptibility to invasion
2017
Invasions pose a large threat to native species, but the question of why some species are more invasive, and some communities more prone to invasions than others, is far from solved. Using ten different three-species bacterial communities, we tested experimentally if the phylogenetic relationships between an invader and a resident community and propagule pressure affect invasion probability. We found that greater diversity in phylogenetic distances between the resident community members and the invader lowered invasion success, and higher propagule pressure increased invasion success whereas phylogenetic distance had no clear effect. In the later stages of invasion phylogenetic diversity ha…
Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology
2007
Three-dimensional Single Photon Emission Computed Tomography (SPECT) can provide high-resolution insight into biomolecular distribution and pharmacokinetics. However, instrument availability and distribution is limited at present,and imaging times can be considerable. To evaluate the large array of novel agents which are becoming available,we find that storage phosphor-based in vivo imaging can provide an important,rapid-throughput transition from the traditional ex vivo sacrifice/gamma counting and autoradiography to full-time course SPECT.
TOMBSTONE REMOVAL : Republication de : Recommandations Formalisées d’Experts. Prise en charge de la patiente avec une pré-éclampsie sévère - RFE Comm…
2021
Abstract Objective To provide national guidelines for the management of women with severe pre-eclampsia. Design A consensus committee of 26 experts was formed. A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. The entire guidelines process was conducted independently of any industrial funding. The authors were advised to follow the principles of the Grading of Recommendations Assessment, Development and Evaluation (GRADE(r)) system to guide assessment of quality of evidence. The potential drawbacks of making strong recommendations in the presence of low-quality evidence were emphasised. Methods The last SFAR and CNGOF guidelines on…
AGE DIFFERENCES IN THE ACUTE STRESS EFFECTS ON DECLARATIVE MEMORY PERFORMANCE
2021
"In the last decades, there has been a growing interest in knowing the effects of acute stress on memory performance, particularly declarative memory. Research on this topic suggests that age is a crucial individual factor to consider in the stress-memory link. However, most of the evidence has been obtained from studies conducted in young people and, surprisingly, studies in older people are scarce. Thus, our aim was to investigate the age differences in the acute stress effects on declarative memory performance. To do this, we directly compared the effects of a psychosocial acute stressor (i.e. Trier Social Stress Test) on learning, consolidation and memory retrieval performance in two ag…
Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 …
2020
Background: Alkaline phosphatase has been found on neuronal membranes and plasma alkaline phosphatase (ALP) activity increases during brain injury and cerebrovascular diseases, suggesting that its levels may reflect the neuronal loss. It is known that ALP is higher in subjects affected by Alzheimer’s dementia and inversely correlated with cognitive functions. No study has investigated the relationship between ALP and cognitive functions in old-age subject with pre-clinical cognitive impairment. Methods: This is a cross-sectional study with data gathered from the ReGAl 2.0 project (Rete Geriatrica Alzheimer-Geriatric Network on Alzheimer’s disease), a large Italian multicentric clinical-base…
Somatosensory mismatch response in young and elderly adults
2014
Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events, diminishes with aging and cognitive decline. However, the effects of aging on the somatosensory MMR (sMMR) are not known. In the current study, we recorded ERPs to electrical pulses to different fingers of the left hand in a passive oddball experiment in young (22–36 years) and elderly (66– 95 years) adults engaged in a visual task. The MMR was found to deviants as compared to…
Magnesium and Alzheimer’s Disease
2015
Environmental factors, including nutrition and metal elements, are implicated in the pathophysiology of Alzheimer’s disease (AD). Several in vitro and in vivo data indicate a role for magnesium (Mg) in many biological and clinical aspects of AD. Mg deficiency, aside from having a negative impact on the energy production pathways required by the mitochondria to generate adenosine triphosphate, also affects many biochemical mechanisms vital for neuronal properties and synaptic plasticity, including the response of N-methyl- d -aspartate receptors to excitatory amino acids, stability, and viscosity of the cell membrane. Mg also has an action as a mild calcium antagonist, and as an antioxidant …
Prenatal Brain Damage in Preeclamptic Animal Model Induced by Gestational Nitric Oxide Synthase Inhibition
2010
Cerebral palsy is a major neonatal handicap with unknown aetiology. There is evidence that prenatal brain injury is the leading cause of CP. Severe placental pathology accounts for a high percentage of cases. Several factors predispose to prenatal brain damage but when and how they act is unclear. The aim of this paper was to determine if hypoxia during pregnancy leads to damage in fetal brain and to evaluate the localization of this injury. An animal model of chronic hypoxia produced by chronic administration of a nitric oxide synthase inhibitor (L-NAME) was used to evaluate apoptotic activity in fetal brains and to localize the most sensitive areas. L-NAME reproduces a preeclamptic-like c…
The clinical implications of cognitive impairment and allostatic load in bipolar disorder.
2011
AbstractBackgroundAllostatic load (AL) relates to the neural and bodily “wear and tear” that emerge in the context of chronic stress. This paper aims to provide clinicians with a comprehensive overview of the role of AL in patophysiology of bipolar disorder (BD) and its practical implications.MethodsPubMed searches were conducted on English-language articles published from 1970 to June 2011 using the search terms allostatic load, oxidative stress, staging, and bipolar disorder cross-referenced with cognitive impairment, comorbidity, mediators, prevention.ResultsProgressive neural and physical dysfunction consequent to mood episodes in BD can be construed as a cumulative state of AL. The con…
J14 Mediterranean Diet And Nutritional Composition Of Patients With Huntington's Disease. Spanish Multicenter Study Of The European Group For Hunting…
2014
Background The impact of a diet is well known in human health. Intake of food groups (fruits and ‘uts, vegetables, legumes, olive oil, whole grains, fish and wine) in the traditional Mediterranean Diet (MeDi) and high MeDi adherence have been associated with lower incidence of chronic diseases and slower cognitive decline, but the relationship between MeDi adherence and nutritional composition has not been reported. Objectives To describe MeDi and nutritional composition in patients with HD. Methods Spanish multicenter, cross-sectional study (EHDN). To assess MeDi we used a 3-days dietary record. Food groups, macro and micronutrients and energy intake information were obtained using the sof…