Search results for "ECL"
showing 10 items of 1262 documents
Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues.
2008
(S)-Curvularin and its 13-, 14-, and 16-membered lactone homologues were synthesized through a uniform strategy in which a Kochi oxidative decarboxylation and ring-closing metathesis reactions constitute the key processes. In the evaluation of the anti-inflammatory effects of the synthesized compounds in assays using cells stably transfected with a human iNOS promoter-luciferase reporter gene construct, the 14- and 16-membered homologues showed a slightly higher inhibitory effect towards iNOS promoter activity than curvularin itself. However, the larger ring homologues also exhibited higher cytotoxicity, manifest in downregulated eNOS promoter activity. In contrast, the di-O-acetyl and 4-ch…
Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's disease.
2014
Background and Purpose: In this study, we demonstrate the use of Molecular topology (MT) in an Alzheimer's disease (AD) drug discovery program. MT uses and expands upon the principles governing the molecular connectivity theory of numerically characterizing molecular structures, in the present case, active anti-AD drugs/agents, using topological descriptors to build models. Topological characterization has been shown to embody sufficient molecular information to provide strong correlation to therapeutic efficacy. Experimental Approach: We used MT to include multiple bioactive properties that allows for the identification of multifunctional single agent compounds, in this case, the dual func…
Targeting the Class A Carbapenemase GES-5 via Virtual Screening
2020
The worldwide spread of &beta
Non-stochastic quadratic fingerprints and LDA-based QSAR models in hit and lead generation through virtual screening: theoretical and experimental as…
2005
In order to explore the ability of non-stochastic quadratic indices to encode chemical information in antimalarials, four quantitative models for the discrimination of compounds having this property were generated and statistically compared. Accuracies of 90.2% and 83.3% for the training and test sets, respectively, were observed for the best of all the models, which included non-stochastic quadratic fingerprints weighted with Pauling electronegativities. With a comparative purpose and as a second validation experiment, an exercise of virtual screening of 65 already-reported antimalarials was carried out. Finally, 17 new compounds were classified as either active/inactive ones and experimen…
Efficient virtual screening using multiple protein conformations described as negative images of the ligand-binding site.
2010
The protein structure-based virtual screening is typically accomplished using a molecular docking procedure. However, docking is a fairly slow process that is limited by the available scoring functions that cannot reliably distinguish between active and inactive ligands. In contrast, the ligand-based screening methods that are based on shape similarity identify the active ligands with high accuracy. Here, we show that the usage of negative images of the ligand-binding site, together with shape comparison tools, which are typically used in ligand-based virtual screening, improve the discrimination of active molecules from inactives. In contrast to ligand-based shape comparison, the negative …
Heritage and the anti-city. Pizzo Sella in Palermo between modern ruins tourism and civic reappropriation
2022
Tutte le nozioni di patrimonio mettono in risonanza i valori della memoria e quelli dell'ambiente antropizzato, poiché entrambi sono intesi come duraturi. Riferendosi al caso iconico della collina di Pizzo Sella a Palermo, questo lavoro affronta il legame peculiare che in questo caso si esprime tra patrimonio, paesaggio e turismo. Per interrogarsi sul modo in cui tale legame segna il rapporto di una comunità con il suo passato, questo contributo si concentra su una nozione critica di patrimonio, inteso come sistema da riconoscere nel costruito dei territori del conflitto fra Stato e criminalità. Questi luoghi, a lungo sotto il controllo delle organizzazioni criminali mafiose, oggi sono prof…
Il mutuo fondiario e la violazione del limite di importo massimo finanziabile: “scotismo” e onnipotenza delle etichette
2023
Il commento analizza una sentenza della Sezioni Unite e affronta il tema delle conseguenze civilistiche dell’erogazione di un mutuo fondiario in misura superiore rispetto al limite di importo massimo finanziabile, stabilito dalla Banca d’Italia in forza dell’art. 38, comma 2, T.U.B. La pronuncia si presenta di grande interesse perché correttamente esclude che il superamento di tale limite possa comportare la nullità del contratto di finanziamento, pervenendo a conclusioni in larga parte condivisibili tanto sui presupposti quanto sulle caratteristiche della nullità per violazione di norme imperative. Non altrettanto fondata si rivela, invece, l’ulteriore conclusione contraria al riconoscimen…
Proceso de una resistencia contra el dominio señorial. Estudio de un pleito de la incorporación a la corona: la villa de Almussafes contra el Monaste…
1980
Un mundo con-sin fronteras
2004
Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies
2021
Hypericumis a widely present plant, and extracts of its leaves, flowers, and aerial elements have been employed for many years as therapeutic cures for depression, skin wounds, and respiratory and inflammatory disorders. Hypericum also displays an ample variety of other biological actions, such as hypotensive, analgesic, anti-infective, anti-oxidant, and spasmolytic abilities. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia, as well as in the treatment of cancer. This review focuses on the in vitro and in vivo antitumor effects of St. John’s Wort (Hypericum perforatum), its derivat…