Search results for "ECL"
showing 10 items of 1262 documents
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…
2016
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…
Abrupt Alnus population decline at the end of the first millennium CE in Europe - The event ecology, possible causes and implications
2019
The study, based on the examination of 70 published and unpublished pollen profiles from Poland and supplementary data from the surrounding regions, shows that an abrupt, episodic Alnus population decline at the end of the first millennium CE was a much more widespread event than has been previously reported, spanning large areas of the temperate and boreal zones in Europe. The data from Poland suggest that the decline was roughly synchronous and most likely occurred between the 9th and 10th centuries, with strong indications for the 10th century. The pollen data indicate that human impacts were not a major factor in the event. Instead, we hypothesize that one or a series of abrupt climatic…
Flowers, Water accumulation and Corporate Social Responsibility: Certification of the Production of Roses and Claims for Environmental Justice in Ecu…
2018
La producción comercial de flores, el acaparamiento del agua y las luchas sociales por un reparto equitativo y un ambiente sano tienen una estrecha relación. Ecuador es el tercer exportador mundial de rosas. Cayambe-Tabacundo es la principal zona de producción y presenta una fuerte presión sobre los recursos hídricos. El agua es acaparada por las grandes empresas florícolas, quedando el resto para agricultura/ganadería de subsistencia en comunidades indígenas. Las florícolas utilizan las certificaciones ambientales y de comercio justo privadas, pero los estándares son permisivos. Este artículo analiza las relaciones de poder detrás de las prácticas de certificación de flores. Concluye que s…
Prenatal Clinical Assessment of sFlt-1 (Soluble fms-like Tyrosine Kinase-1)/PlGF (Placental Growth Factor) Ratio as a Diagnostic Tool for Preeclampsi…
2013
Background: Aim of the study was a critical assessment of the clinical validity of the prenatal determination of sFlt-1/PlGF for preeclampsia (PE), pregnancy-induced hypertension (PIH), and proteinuria. Our analysis was based on a specificity of 95 % and a sensitivity of 82 % for the prediction of preeclampsia, as described by Elecsys (Roche). Methods: In this retrospective study the ratio of the prenatal antiangiogenic factor sFlt-1 (soluble fms-like tyrosine kinase-1) to the proangiogenic factor PIGF (placental growth factor) was analyzed using the electrochemiluminescence immunoassay of Elecsys (Roche Diagnostics, Mannheim, Germany) in 173 pregnant women. Sixty-three women with PE, 34 wo…
Is a Joint Declaration on the Church and Ministry Possible Right Now? Reflections on the Potential of Ecclesiological Pluralism in Lutheran–Roman Cat…
2021
L’Horta, agricultura y ciudad: historia y presente. Valencia capital mundial de la alimentación en 2017 / L’Horta, agriculture and city: history…
2018
La produccion agraria en fresco para el consumo de proximidad se plantea como una opcion para el mantenimiento de la Huerta como paisaje unico y como una estrategia complementaria de desarrollo (Especializacion Inteligente). El nuevo plan subregional de ordenacion del territorio de la Huerta de Valencia, y la ley que lo acompana, ponen en primer plano la recuperacion del valor productivo de este espacio como parte de la nueva Infraestructura Verde. En el articulo estas cuestiones se ponen en relacion con la declaracion de Valencia como capital mundial de la alimentacion; un ejemplo de «reconversion» de la estrategia de grandes eventos del pasado, pero con una orientacion diametralmente opue…
The contamination legacy of a decommissioned iron smelter in the Italian Alps
2018
The economically important activity of metal processing can tend to contribute to the degradation of the environment. Smelting is an important source of contaminants, dispersing large quantities of potentially toxic elements (PTE) and coproducts into the environment. Soils in the vicinity of smelters frequently contain high concentrations of PTE. In terms of the quantities processed, the major PTE are iron (Fe), aluminium (Al), copper (Cu), lead (Pb), manganese (Mn), and zinc (Zn); of these Cu, Pb and Zn are, potentially, highly hazardous elements. The general problem addressed by this study is to determine if the PTE concentration in the soils of an area downwind from a decommissioned iron…
Moderate alcohol use and health: a consensus document
2013
Abstract Aims The aim of this consensus paper is to review the available evidence on the association between moderate alcohol use, health and disease and to provide a working document to the scientific and health professional communities. Data synthesis In healthy adults and in the elderly, spontaneous consumption of alcoholic beverages within 30 g ethanol/d for men and 15 g/d for women is to be considered acceptable and do not deserve intervention by the primary care physician or the health professional in charge. Patients with increased risk for specific diseases, for example, women with familiar history of breast cancer, or subjects with familiar history of early cardiovascular disease, …
Population Decline of the Capercaillie Tetrao urogallus aquitanicus in the Central Pyrenees
2020
El seguimiento a largo plazo de las aves amenazadas es esencial para estimar las tendencias poblacionales e identificar las posibles causas de declive, siendo particularmente importante en el caso de las aves alpinas que habitan en areas montanosas en los limites de su area de distribucion. Analizamos la tendencia poblacional del urogallo en los Pirineos centrales espanoles a partir de investigaciones realizadas entre 2000 y 2017. Encontramos un declive significativo de la poblacion (alrededor del 58%) en el numero de aves contadas en las areas de exhibicion (lek). la mayoria de los urogallos habitan bosques de coniferas de pino negro con una cobertura elevada de arandano y rododendro en el…
Residential Change and Socio-demographic Challenges for Large Housing Estates in Riga, Latvia
2019
Large housing estates from the socialist era are a characteristic feature of the built environment in the cities of Central and Eastern Europe. Many urban researchers are increasingly interested in residential changes in these areas, showing how demographic and socioeconomic processes interact with the decline or upgrading of this distinct type of housing. In Europe, the debate concerning large housing estates is largely related to a declining and ageing population, as well as to housing conditions. In Latvia, the underdeveloped housing market and the massive privatisation of the housing stock to sitting tenants have contributed, since the late-Soviet period, to inherited socio-spatial stru…