Search results for "EDM"

Direct identification of the agonist binding site in the human brain cholecystokinin-B receptor

1999

In investigating the agonist binding site of the human brain cholecystokininB receptor (CCKBR), we employed the direct protein chemical approach using a photoreactive tritiated analogue of sulfated cholecystokinin octapeptide, which contains the p-benzoylbenzoyl moiety at the N-terminus, followed by purification of the affinity-labeled receptor to homogeneity. This probe bound specifically, saturably, and with high affinity (KD = 1.2 nM) to the CCKBR and has full agonistic activity. As the starting material for receptor purification, we used stably transfected HEK 293 cells overexpressing functional CCKBR. Covalent labeling of the WGA-lectin-enriched receptor revealed a 70-80 kDa glycoprote…

The rhythm of stability: Husserl's worlds and Deleuze's territories

2019

On the Complexity and Wholeness of Human Beings: Husserlian Perspectives

2017

At the beginning of Being and Time, Heidegger rejects Husserl’s classical phenomenology on three grounds: he claims that Husserlian phenomenology is impaired by indeterminate concepts, by naïve personalism, and by obscurities in its account of individuation. The paper studies the validity of this early critique by explicating Husserl’s discourse on human persons as bodily-spiritual beings and by clarifying his account of the principles by which such beings can be individuated. The paper offers three types of considerations. After a summary of Heidegger’s early critique of Husserl, the second section of the paper distinguishes between two dimensions of Husserl’s discourse on human persons. I…

A model for the very early universe

2008

A model with N species of massless fermions interacting via (microscopic) gravitational torsion in de Sitter spacetime is investigated in the limit N->infinity. The U_V(N)*U_A(N) flavor symmetry is broken dynamically irrespective of the (positive) value of the induced four-fermion coupling. This model is equivalent to a theory with free but massive fermions fluctuating about the chiral condensate. When the fermions are integrated out in a way demonstrated long ago by Candelas and Raine, the associated gap equation together with the Friedmann equation predict that the Hubble parameter vanishes. Introducing a matter sector (subject to a finite gauge symmetry) as a source for subsequent cos…

The cosmological constant problem in codimension-two brane models

2005

We discuss the possibility of a dynamical solution to the cosmological constant problem in the contaxt of six-dimensional Einstein-Maxwell theory. A definite answer requires an understanding of the full bulk cosmology in the early universe, in which the bulk has time-dependent size and shape. We comment on the special properties of codimension two as compared to higher codimensions.

Adiabatic expansions for Dirac fields, renormalization, and anomalies

2018

11 pags.

Social Invisibility and Emotional Blindness

2020

The unsettling, humiliating, and often threatening experience of feeling oneself ‘invisible’ before the gazes of other people in one’s social world has obvious potential as a theme for collaborative efforts between social theorists and phenomenologists. This chapter proposes one way of approaching such an engagement, drawing in particular upon three authors who offer detailed analyses of social visibility and its potential pathologies: Axel Honneth, Frantz Fanon, and Edmund Husserl. The specific phenomenon is first be located by way of Honneth’s treatment of social invisibility as frequented by behaviour that expresses an attitude of nonrecognition towards other persons immediately present.…

Intuition and meaning. The Husserlian doctrine of intuitive sense in the contemporary field of reflection

1999

Intuition, verstanden als analoge, nicht-diskursive Darstellungsweise, ist bei Husserl seit jeher klar vom symbolischen Denken in der Sprachproduktion abgegrenzt. Anfänglich abhängig vom symbolischen Denken, das bis zu den Logische Untersuchungen als einziges Sinnvehikel erscheint, gewinnt die Intuition aus Ideen allmählich einen Grundwert und eine Autonomie des Funktionierens und wird zum Ort der Wahl einer bestimmten Bedeutung. Daher wird eine Theorie der intuitiven Sinn konstruiert, die vom Fregeenschen Bedeutungsmodell befreit ist, trotz Husserls Zurückhaltung, alle ihre Implikationen zuzugeben. Die Analyse dieser Theorie erfolgt parallel zur zeitgenössischen Kognitionsforschung, in der…

Edmund Husserl

2020

This chapter indicates that Edmund Husserl’s published and unpublished writings contain important contributions to the phenomenological study of emotional life, and to our understanding of the emotions more broadly. It focuses on Husserl’s most productive and significant period as a phenomenologist of the emotions dating between the publication of Logical Investigations in 1900 and Ideas I in 1913. In the second volume of Logical Investigations, Husserl briefly takes up the question of whether the phenomenologist ought to class feelings (Gefühle) as intentional experiences. Non-intentional feelings are exclusively confined to what Husserl calls sensory feelings (sinnliche Gefühle) or affect…

Anonymity of the ‘Anyone’ : The Associative Depths of Open Intersubjectivity

2018

Husserl’s concept of “open intersubjectivity” expresses the peculiarity that the environment appears as being there for “anyone”. The structurally implicated, potential co-perceivers have been rendered anonymous, unspecified, which is another way of saying that the horizontally implicated “anyone” refers to no one in particular, but to “any alter egos whatever”. My article focuses on this tacit structural referencing to potential others and challenges the claim of anonymity. In the literature, it has been argued that the potential others are implicitly specified as co-members of our community, or “homecomrades”. I will push the idea of specification further, and into a new direction, by arg…