Search results for "EFA"
showing 10 items of 1142 documents
Twenty Years of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Time to Reevaluate their Toxicity
2011
Twenty years of effective clinical application have consolidated non-nucleoside reverse transcriptase inhibitors (NNRTI) as essential components of the Highly Active Antiretroviral Therapy (HAART) employed in the treatment of Human Immunodeficiency Virus (HIV). However, as the disease has come under control, there has been growing emphasis on the long-term adverse effects induced by this chronic pharmacological therapy. Although traditionally considered to be safe and well-tolerated drugs, there is mounting evidence that associates NNRTI with the onset of cutaneous reactions, neuropsychiatric symptoms, hepatotoxicity, metabolic disturbances and gastrointestinal toxicity. Though the clinical…
Future Perspectives in NNRTI-Based Therapy: Bases for Understanding Their Toxicity
2011
Continuous administration of the drugs included under the term Highly Active Antiretroviral Therapy (HAART) has turned AIDS into a chronic disease, at least in developed countries (Panos et al., 2008). The initial development of these drugs was particularly rapid and focused on clinical efficacy before all other considerations. However, as the disease has come under control, there has been growing emphasis on the long-term adverse effects associated with this therapy. The first drug for the treatment of HIV infection, zidovudine (AZT), was approved in 1987. The number of other antiretroviral drugs already approved for use or under development continues to grow, and the primary aim of resear…
Efavirenz induce una respuesta diferencial en la bioenergética y función mitocondrial de neuronas y células gliales
2014
Efavirenz (EFV) es el inhibidor de la transcriptasa inversa no análogos de nucleósidos (ITINAN) más ampliamente utilizado en el tratamiento de la infección por el VIH. Durante muchos años ha contribuido significativamente a la evolución de la terapia antirretroviral de gran actividad (TARGA) y a pesar de ser considerado un fármaco seguro y bien tolerado, existe una creciente preocupación debido a que los regímenes que lo contienen han sido asociados con efectos adversos, siendo los trastornos neuropsiquiátricos la reacción adversa más notable y un factor de riesgo para el fracaso de la terapia. Los mecanismos responsables no han sido caracterizados, aunque algunos trabajos recientes vincula…
Real-Time Localization of Epileptogenic Foci EEG Signals: An FPGA-Based Implementation
2020
The epileptogenic focus is a brain area that may be surgically removed to control of epileptic seizures. Locating it is an essential and crucial step prior to the surgical treatment. However, given the difficulty of determining the localization of this brain region responsible of the initial seizure discharge, many works have proposed machine learning methods for the automatic classification of focal and non-focal electroencephalographic (EEG) signals. These works use automatic classification as an analysis tool for helping neurosurgeons to identify focal areas off-line, out of surgery, during the processing of the huge amount of information collected during several days of patient monitori…
Associations between structures, processes and outcomes in inter-municipal cooperation in out-of-hours services in Norway: A survey study
2020
Abstract Inter-municipal cooperation (IMC) has gained widespread recognition as a beneficial strategy for improving efficiency and quality in the provision of out-of-hours emergency care services (OOH services). Little attention, however, has been given to the additional costs of cooperation and the relational processes through which benefits and costs are likely to result. Based on survey data from 266 (77%) Norwegian municipalities involved in IMC in OOH services in 2015, this study aimed to investigate how the structure (governance form, complexity and stability) and quality (trust and consensus) of cooperation processes interact to influence the perceived outcomes (benefits and costs) o…
Risky Lives? Self-Directed Violence and Violence From Others Among Young People Not in Education, Employment, or Training (NEET)
2022
Self-directed violence and violence from others comprise a major public health concern in youth. However, we lack knowledge about the prevalence of violent experiences among young people that are not in education, employment, or training (NEET), whether violent occurrences are similar among girls and boys, and whether violence differs between NEET youths and young students. This cross-sectional study compared the occurrences of self-directed violence (suicide attempts and self-harm) and exposure to violence from others (violent threats, beaten without visible marks, or injured due to violent events) between 96 NEET youth and 384 age- and sex-matched upper secondary school students (16–21 ye…
Experiences of participating in individual placement and support: a meta‐ethnographic review and synthesis of qualitative studies
2019
Aim To provide increased understanding about how work applicants, employment specialists, social workers in the welfare service and clinicians in mental healthcare service experience participating in individual placement and support (IPS). Methods We searched in several databases and identified 17 studies published from 2007 to 2017 in Sweden, USA, Canada, UK, Australia and Denmark, and applied meta-ethnographic reinterpretation and synthesis. Results The employment specialists followed the core ideas of IPS, where work is seen as a way to recover. They saw the work applicants' preferences and needs as important for health and well-being, and crucial for successful work rehabilitation. In o…
Conceptual study of the coupling of a biorefinery process for hydrothermal liquefaction of microalgae with a concentrating solar power plant
2017
A conceptual analysis of the coupling of a concentrating solar power plant with a chemical process for hydrothermal liquefaction (HTL) of microalgae to biocrude was performed. The two plants were considered coupled by molten salt recirculation that granted energetic supply to the chemical process. Preliminary estimations have been done considering a solar field constituted by 3 linear parabolic solar collectors rows, each 200 m long, using a ternary molten salts mixture as heat transfer fluid, and a chemical plant sized to process 10 kT/y of microalgae. Under adopted conditions, we have estimated a minimum selling prize of the biocrude that is similar to that achieved in non-solar HTL proce…
New solutions for prefabricated secondary substations in the view of sustainability
2016
The secondary substations will assume an important role as “smart nodes” of the smart grid. So in few years there will be a widespread dissemination on the territory of this apparatus. Consequently, great care have to be taken not only on safety issues, but also on the constructive methodology, in order to determine low environmental impact and decommissioning cost. This paper focuses on innovative solutions for the realization of prefabricated secondary substations, in the direction of sustainability. Innovative layout and enclosure topologies have been here taken into account. In particular, by considering that the substation concrete box is, at the same time, uneconomical and with strong…
A back to back method for the temperature rise test of prefabricated substations: A case study
2015
In this work a back to back method is presented which allows to develop heating tests of prefabricated secondary substations with a limited number of supplying equipment (an induction regulator and a capacitor bank). The proposed method makes use of the transformer tap changers to create a voltage difference on the medium voltage side. In this way, only an adjunctive low voltage supply is needed. With the proposed test system, the heating tests are developed on a 1000 kVA prefabricated substation. Thanks to the experimental tests, the class of enclosure of the substation and the operating temperature and resistance of the power transformers are determined, according to the recommendations o…