Search results for "EFFICACY"
showing 10 items of 588 documents
Persistence of protection through 33 months of age provided by immunization in infancy with two three-component acellular pertussis vaccines
1998
Abstract A large, randomized, placebo-controlled clinical trial in Italy on two three-component pertussis vaccines, given as DTaP in infancy, one manufactured by SmithKline and Beecham (SB) and one by Chiron Biocine (CB), found each vaccine to be 84% efficacious through the average age of 24 months. The cohort of children envolled in the trial was followed with unmodified case ascertainment procedures for nine additional calendar months, during which partial unblinding occurred, for the unvaccinated randomized group. For the DTaP groups, the specific vaccine assignment remained double-blinded throughout the entire additional observation period. Pertussis was defined as paroxysmal cough last…
Efficacy of Acellular Pertussis Vaccine in Early Childhood After Household Exposure
1996
Objective. —To evaluate the efficacy of a three-dose primary vaccination with a diphtheria-tetanus tricomponent acellular pertussis vaccine against "typical" pertussis, defined as a spasmodic cough of 21 days or longer with confirmation of Bordetella pertussis infection by culture or serology. Design. —Passive monitoring for suspected first household (index) cases of typical pertussis in six areas in Germany comprising 22 505 children vaccinated with study vaccine at 3, 4, and 5 months of age. Blinded, prospective follow-up of household contacts of index cases for incidence and progression of pertussis. Setting. —Six areas in Germany with a high incidence of pertussis. Subjects. —Four hundr…
Coverage, efficacy or dosing interval: which factor predominantly influences the impact of routine childhood vaccination for the prevention of varice…
2016
Background Varicella is a highly infectious disease with a significant public health and economic burden, which can be prevented with childhood routine varicella vaccination. Vaccination strategies differ by country. Some factors are known to play an important role (number of doses, coverage, dosing interval, efficacy and catch-up programmes), however, their relative impact on the reduction of varicella in the population remains unclear. This paper aims to help policy makers prioritise the critical factors to achieve the most successful vaccination programme with the available budget. Methods Scenarios assessed the impact of different vaccination strategies on reduction of varicella disease…
Timing of activation of CD4+ memory cells as a possible marker to establish the efficacy of vaccines against contagious agalactia in sheep
2013
Mycoplasma agalactiae is a major pathogen of sheep and goats in many areas of the world and particularly in Mediterranean countries. It causes contagious agalactia, an infectious disease primarily affecting mammary glands. Many vaccines against the pathogen are currently under development. The aim of the study was to investigate the involvement of T cell-mediated immunity during vaccination and challenge experiments against Mycoplasma agalactiae. A comparison of the antigen-specific expansion of interferon gamma positive T cell memory and naïve subsets was performed between vaccinated and non-vaccinated sheep to identify cellular subsets whose activation was different between protected and …
Validation of Teacher Self-efficacy (QAI) Questionnaire
2021
Negli ultimi anni numerose ricerche nazionali e internazionali hanno messo in evidenza l’importanza della Teacher Self Efficacy. Nonostante nel panorama nazionale esistano già alcuni strumenti che indagano tale costrutto, si notano sovrapposizioni e divergenze nei diversi fattori presi in considerazione, quali ad esempio la percezione di autoefficacia relativa alla possibilità di agire sull’engagement degli studenti e sulla colla- borazione con la famiglia e altre figure professionali. Pertanto l’obiettivo del presente contributo consiste nella costruzione e validazione di un nuovo strumento che tenga conto di entrambi quest’ultimi aspetti. Lo strumento, costituito da 25 item, è stato so…
Assembling a consensus on actinic cheilitis: A Delphi study.
2021
Aims: To discuss the terminology to define and classify actinic cheilitis (AC) and to build a consensus on the diagnostic and therapeutic approaches to AC. Methods: Two-round Delphi study using a questionnaire including 34 closed sentences (9 on terminology and taxonomy, 5 on potential for malignant transformation, 12 on diagnostic aspects, 8 on treatment) and 8 open questions. Experts’ agreement was rated using a Likert scale (1–7). Results: A consensus was reached on 24 out 34 statements (73.5%) and on 5 out of 8 (62.5%) close-ended questions. The response rate was identical in both rounds (attrition of 0%). AC is the term with the highest agreement (median of 7 (strongly agree; IQR: 6–7)…
A randomized phase II study of estramustine phosphate versus estramustine phosphate plus etoposide in hormone refractory prostate cancer (HRPC)
2008
20632 Background: Docetaxel-based regimens represent the treatment of choice of HRPC. However, in some patients toxicity may be a concern and the quality of life may be compromised. The aim of this phase II randomized study is to investigate the efficacy and safety of low-dose chemotherapy regimen adopting a combination of EMP and VP16 in patients affected by HRPC. Methods: 54 HRPC patients were randomized between: arm A, daily oral standard dose EMP (10mg/kg) and arm B, low-dose EMP (3mg/kg) plus VP16 (25mg/mq) for 2 weeks followed by 2-weeks’rest. Systemic toxicity and hematologic exams were monitored every 2 weeks. Performance status, pain and analgesic use were evaluated according to WH…
Effects of combined exercise on psychological and physiological variables in cancer patients: A pilot study
2020
Purpose: The aim of this study was to investigate the effect of a short-term combined exercise intervention program on perceived self-efficacy, fatigue, lower back flexibility, balance and task specific functional mobility in cancer patients. Materials and Methods: Fifteen patients met all the eligibility criteria and were assigned to a single training group (range age, 22-75 years) that performed an 8-week intervention program (∼60min, 2dwk-1). Each session included a progressive training of cardiorespiratory, resistance, flexibility and postural education exercises. Measures pre-intervention and post-intervention included psychological and physiological measurements. Adherence to training…
Cardioprotective effects of phytopigments via multiple signaling pathways.
2021
Abstract Background Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both in vitro and in vivo. Purpose This review gives an overview of the cardioprotective effects of phytopigments based on in vitro and in vivo studies as well as clinical trials. Methods A literature-based survey was performed to collect the available data on cardioprotective activities of phytopigments via electronic search engines such as Pub…
Self-efficacy and perceived control in the prevention of cardiovascular disease
2010
Desde la Teoría de Acción Planeada (TAP), el objetivo de este trabajo es analizar si la autoeficacia y la percepción de control presentan diferencias predictivas sobre la intención y las conductas preventivas de la enfermedad cardiovascular. La muestra estuvo compuesta por 359 sujetos. Los datos han sido analizados empleando el paquete estadístico EQS 6.1. Los resultados muestran que la autoeficacia influye positiva y significativamente sobre la intención y sobre la conducta, mientras que la percepción de control influye negativa y significativamente sobre la intención de conducta, pero no sobre la conducta preventiva. Este trabajo ha mostrado la conveniencia de distinguir entre autoeficaci…