Search results for "EMBER"
showing 10 items of 549 documents
B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.
2010
Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy el…
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1997
Abstract The molecular characterization of T-cell-defined tumor-associated antigens has provided targets for cell-mediated immunotherapy for malignant diseases. The success of this strategy is negatively influenced by structural and functional abnormalities of major histocompatibility complex (MHC) class I molecules, which provide tumor cells with resistance to T-cell-mediated immune recognition. This article reviews the physiology of the MHC class I processing machinery and describes the deficiencies of this pathway in malignant cells.
INTRODUZIONE AL D.LGS. 19 GENNAIO 2017, N. 3, DI ATTUAZIONE DELLA DIR. 2014/104/UE SUL RISARCIMENTO DEI DANNI PER VIOLAZIONE DELLA NORMATIVA ANTITRUST
2018
Con l’emanazione del d.lgs. 19 gennaio 2017, n. 3 e` stata data attuazione alla direttiva 2014/104/UE del Parlamento e del Consiglio del 26 novembre 2014, relativa a determinate norme che regolano le azioni per il risarcimento del danno ai sensi del diritto nazionale per violazioni delle disposizioni del diritto della concorrenza degli Stati membri e dell’Unione europea. Lo scritto, nell'introdurre una serie di commenti alla neo-introdotta normativa, esamina il percorso evolutivo che ha condotto all'emanazione della direttiva, le scelte con essa operate e le modalità di recepimento nell'ordinamento italiano. With the issuance of Legislative Decree January 19, 2017, no. 3 was implemented the…
Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial B…
2014
International audience; The objective of this study was to evaluate the biological activities of the major phytosterols present in argan oil (AO) and in cactus seed oil (CSO) in BV2 microglial cells. Accordingly, we first determined the sterol composition of AO and CSO, showing the presence of Schottenol and Spinasterol as major sterols in AO. While in CSO, in addition to these two sterols, we found mainly another sterol, the Sitosterol. The chemical synthesis of Schottenol and Spinasterol was performed. Our results showed that these two phytosterols, as well as sterol extracts from AO or CSO, are not toxic to microglial BV2 cells. However, treatments by these phytosterols impact the mitoch…
The Southern African Development Community (SADC): An Analytical Overview of Its History, Policies and Institutional Framework
2017
This chapter gives fundamental background information about the history and development of regionalism in Southern Africa and about the current state of the SADC as a modern regional integration organisation. In terms of an analytical overview, Muntschick reflects briefly on the formation, character and objectives of the region’s old regionalisms such as the Southern African Customs Union (SACU), the Frontline States (FLS) and particularly the Southern African Development Co-ordination Conference (SADCC) as predecessors of the SADC. Also, this chapter turns to the new regionalism and provides detailed information on the SADC as an organisation, its member states, key agenda and central poli…
The use of steel angles for the connection of laminated glass beams: Experiments and modelling
2012
Abstract In the present paper the experimental results relative to three-point bending tests on multilayer glass beams and on semi-rigid connections realised with stainless double web angles are presented and discussed. Small and medium size glass beams were tested and load–deflection curves and crack patterns at failure were recorded. The laminated glass specimens, of equal cross-section, were characterised by three different combinations of annealed float and fully thermally tempered glass plies and different interlayers. Steel joints constituted by double web angles to connect two glass beams were tested adopting several geometrical configurations and using stainless steel bolts preloade…
Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages rela…
2010
Recently it has been reported that low serum IL-10 levels are associated with an increased susceptibility for metabolic syndrome and type 2 diabetes mellitus (T2DM). We investigated whether the -1087G/A (rs1800896), -824C/T (rs1800871), -597C/A (rs1800872) IL-10 polymorphisms were associated with type 2 diabetes in a study on a cohort of Italian Caucasians comprising 490 type 2 diabetic and 349 control subjects. Stratifying the data according to IL-10 genotypes, trends for the progressive increase of glucose and neutrophil levels were observed in -1087GG vs. -1087GA vs. -1087AA positive diabetic patients (-1087GG < -1087GA < -1087AA). In addition, evaluating the laboratory parameters accord…
Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice
2010
Abstract Background P-glycoprotein (P-gp), an efflux transporter localized in the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). For the new antipsychotic aripiprazole and its active metabolite dehydroaripiprazole differences in disposition in blood and brain were investigated after acute and sub-chronic administration in a P-gp knockout mouse model. Methods Serum and brain concentrations of both drugs were measured at several time points 1–24 h after i.p. injection of 10 mg/kg aripiprazole and after 11 days of sub-chronic administration in several tissues. Moreover, the expression of P-gp was determined by Western blot analysis after sub…
Th17 immunity in children with allergic asthma and rhinitis: a pharmacological approach
2013
Th17 cells and IL-17A play a role in the development and progression of allergic diseases. We analyzed the IL-17A levels in sputum supernatants (Ss), nasal wash (NW) and plasma (P) from Healthy Controls (HC) and children with Asthma/Rhinitis. We tested the expression of IL-17A, RORγ(t) and FOXP3 in peripheral blood T-lymphocytes from intermittent and mild-moderate asthma. The effect of Budesonide and Formoterol was tested "in vitro" on IL-17A, RORγ(t) and FOXP3 expression in cultured T-lymphocytes from mild-moderate asthma/persistent rhinitis patients, and on nasal and bronchial epithelial cells stimulated with NW and Ss from mild-moderate asthma/persistent rhinitis. Further, the effect of …
Simplified technique for constitutive analysis of SFRC
2014
Steel fibre reinforced concrete (SFRC) has become widespread material in areas such as underground shotcrete structures and industrial floors. However, due to the absence of material models of SFRC reliable for numerical analysis, application fields of this material are still limited. Due to interaction of concrete with fibres, a cracked section is able to carry a significant portion of tensile stresses, called the residual stresses. In present practices, residual stresses used for strength, deflection and crack width analysis are quantified by means of standard tests. However, interpretation of these test results is based on approximation using empirically deduced relationships, adequacy o…