Search results for "EMBER"
showing 10 items of 549 documents
The Migration Crisis: An Introduction
2020
In 2015, the EU and its member states struggled to coordinate, communicate, and cooperate on the migration crisis as the chapters in this section show. Schilde and Wallace Goodman point out that while border security contains examples of deeper integration, asylum management policy has followed the scenarios of breaking down and muddling through. All the authors highlight the Dublin convention as particularly ill-devised and thus paving the way for the refugee crisis. Bosilca finds evidence for breaking down in addition to minimal reforms of border security policy that constitute muddling through. Crawford argues that the migration crisis provides evidence both of muddling through and headi…
Implementing Cultural Diversity Within and Outside the European Union: A Test for the Delineation of Competences in Cultural Matters?
1970
The purpose of this paper is to evaluate the European Union’s (EU) involvement in the protection of cultural diversity, both within and outside the EU, after the entering into force of the Lisbon Treaty, in 2009, and the adoption of the UNESCO Convention of 2005. The author examines whether this involvement can be depicted in concrete measures aiming at the effective internal and external implementation of the provisions of the UNESCO Convention of 2005. The author further seeks to analyse whether the entailed consequences of EU’s actions, including the erosion of the Member State's competences in the cultural field, was translated in concrete measures or if it still remains at the politica…
Thermally Induced Structural Modification of Silica Nanoparticles Investigated by Raman and Infrared Absorption Spectroscopies
2010
We report an experimental investigation by Raman and infrared (IR) absorption spectroscopies on the structural modifications induced by isochronal thermal treatments on amorphous SiO2 nanoparticles (fumed silica). In particular, three different commercial types of this material, characterized by particle mean diameters of 7, 14, and 40 nm, were subjected to thermal treatments from 100 up to 1000 °C. We found that some properties of fumed silica, such as the SiOSi mean bond angle, ring size distribution, and surface adsorbed water content, are drastically different from those of common bulk silica materials and intimately related to the particles' dimension. The SiOSi mean bond angle, probed…
Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the intensive care unit: A Scandinavian cro…
2022
ObjectivesTo examine conditions and strategies to meet the challenges imposed by the coronavirus disease 2019 (COVID-19)-related visiting restrictions in Scandinavian intensive care units.Research methodology/designA cross-sectional survey.SettingAdult intensive care units in Denmark, Norway and Sweden.Main outcome measuresLikert scale responses and free-text comments within six areas: capacity and staffing, visiting policies and access to the unit, information and conferences with relatives, written information, children as relatives and follow-up initiatives.ResultsThe overall response rate was 53% (74/140 participating units). All intensive care units had planned for capacity extensions;…
The European Union’s Strategy for the Baltic Sea Region (EUSBSR): improving multilevel governance in Baltic Sea cooperation?
2017
ABSTRACTMacro-regional strategies – such as the ones for the Baltic Sea, the Danube, the Ionian-Adriatic, and the Alpine regions – constitute new elements of European Union (EU) Cohesion Policy and territorial cooperation. In a nutshell, these strategies aim at building functional and transnational ‘macro-regions’ involving the EU, its member states, as well as partner countries within the EU’s system of multilevel governance (MLG). As the oldest macro-regional strategy, the EU Strategy of the Baltic Sea Region has been in operation since 2009. Drawing on the theory of MLG, this contribution assesses the effects on the political mobilization and interplay between international, intergovernm…
The rising fear of terrorism and the emergence of a European security governance space: citizen perceptions and EU counterterrorism cooperation
2021
Among a wide range of challenges, EU member states have been facing a growing threat from terrorism in the recent years. The primary responsibility for combating terrorism lies with each individual member state, although the threat is becoming increasingly cross-border and diverse. Regardless of whether terrorism poses a real or perceived threat to the states’ and citizens’ security, public opinion is one important force behind the extensive counterterrorism efforts undertaken in Europe. In this article, we explore the influence of public opinion on EU policy within the security domain in the period 2005–19. We investigate the relationship between the number of attacks carried out on EU ter…
A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.
2011
Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular "xenosensors" like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicate…
Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cel…
2003
ABSTRACTThe mechanisms of immune evasion and the role of the early immune response in chronic infection caused by hepatitis C virus (HCV) are still unclear. Here, we present evidence for a cascade of molecular events that the virus initiates to subvert the innate immune attack. The HCV core protein induced p53-dependent gene expression of TAP1 (transporter associated with antigen processing 1) and consecutive major histocompatibility complex (MHC) class I upregulation. Moreover, in p53-deficient liver cell lines, only reconstitution with wild-type p53, but not mutated p53 lacking DNA binding capacity, showed this effect. As a consequence of increased MHC class I expression, a significantly …
Impaired Transporter Associated with Antigen Processing (TAP) Function Attributable to a Single Amino Acid Alteration in the Peptide TAP Subunit TAP1
2003
Abstract The heterodimeric peptide transporter TAP belongs to the ABC transporter family. Sequence comparisons with the P-glycoprotein and cystic fibrosis transmembrane conductance regulator and the functional properties of selective amino acids in these ABC transporters postulated that the glutamic acid at position 263 and the phenylalanine at position 265 of the TAP1 subunit could affect peptide transporter function. To define the role of both amino acids, TAP1 mutants containing a deletion or a substitution to alanine at position 263 or 265 were generated and stably expressed in murine and human TAP1−/− cells. The different TAP1 mutants were characterized in terms of expression and funct…
Adaptive control of a seven mode truncation of the Kolmogorov flow with drag
2009
Abstract We study a seven dimensional nonlinear dynamical system obtained by a truncation of the Navier–Stokes equations for a two dimensional incompressible fluid with the addition of a linear term modelling the drag friction. We show the bifurcation sequence leading from laminar steady states to chaotic solutions with increasing Reynolds number. Finally, we design an adaptive control which drives the state of the system to the equilibrium point representing the stationary solution.