Search results for "EMBER"
showing 10 items of 549 documents
Study on the Evolution of Defense Expenses in Nato Member States for the Period 2010–2020. “Free Rider” behavior among Allies
2021
Abstract This paper proposes a longitudinal study on the analysis of defense spending of NATO member states in the years 2010-2020. It also aims to identify the emergence of a possible “free-rider” behavior among alliance members. This behavior occurs when some members may be tempted to allocate a low level of defense spending. Defense spending is an important component of each state’s budget, which ensures a vital function of states, namely the national defense function. When the defense is carried out in military-type alliances, and the number of members is large, there is an increased possibility of observing a “free-rider” type behavior between the members of the alliances. To observe t…
Media effects on policy preferences toward free movement: evidence from five EU member states
2020
In a time when freedom of movement is being challenged by an increasing number of European Union member states, and where immigration has been dominating public debate for years, this study investi...
A new political elite in France : the end of professionalization ?
2020
Actes du projet Parcit (Participation et citoyenneté), financé par les MSH Dijon et Besançon, co-dirigé par A. Alexandre-Collier, D. Andolfatto et A. Goujon, 2017-2019; International audience; Who governs? It is this classic question in political science (Dahl, 1961) that this chapter seeks to answer. It is based on a tradition of studying parliamentary elites (Best & Cotta, 2000 & 2007 ; Norris, 1997). It proposes to analyze the sociological make up of the French National Assembly elected in June 2017. Of course, this is not the sociology of government in the strict sense of the executive power but that of the parliamentary Assembly elected by direct universal suffrage and supposed to adop…
Has the Push for Equal Gender Representation Changed the Role of Women on German Supervisory Boards?
2017
In Germany, an intensive public debate about increasing female participation in leadership positions started in 2009 and proceeded until the beginning of 2015, when the German parliament enacted a board gender quota. In that period, the share of women on supervisory boards for 111 German publicly listed and fully codetermined companies (i.e. those which are affected by the quota law) more than doubled from 10.6 percent in 2009 to 22.6 percent in 2015. In 2016, the first year when the law was effective, the female share increased again by 4.5 percentage points. Using a hand-collected dataset, we investigate whether the rise in female board representation was accompanied by a change in gender…
construcción de una europa más igualitaria desde la protección de las víctimas de violencia de género
2021
El propósito de este artículo es analizar las aristas de la Directiva sobre la Orden Europea de Protección cuando se trata de proteger a las víctimas de violencia de género. El inexistente concepto de víctima de violencia de género dificulta sobremanera el adecuado uso del instrumento y nos muestra cuánta Europa queda por construir. Al final del artículo proponemos la creación de una medida cautelar civil para acercarnos al resto de ordenamientos jurídicos de nuestro entorno y facilitar el reconocimiento mutuo.
Can aromaticity be connected with molecular polarizability? A theoretical study of benzene isomers and five-membered heterocyclic molecules
2004
Extended calculations of molecular electric dipole polarizability tensor, at Hartree-Fock and correlated level of accuracy (MP2, CCS, CC2, CCSD, and CCSD(T)) have been carried out to investigate whether aromaticity could be related to the electric dipole polarizability of planar ring systems. The calculations prove the exaltation of the average property of conjugated molecules, which is possibly due to their easily polarizable π-electron cloud. On the other hand, theoretical out-of-plane polarizability components are smaller in benzene than in any other C$_6$H$_6$ isomer. The aromatic stabilization energies of monosubstituted five-membered conjugated cyclic molecules increase in the same di…
Genetic background in nonalcoholic fatty liver disease: A comprehensive review
2015
In the Western world, nonalcoholic fatty liver disease (NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but it is also regulated by genetic background. The role of heritability has been widely demonstrated by several epidemiological, familial, and twin studies and case series, and likely reflects the wide inter-individual and inter-ethnic genetic variability in systemic metabolism and wound healing response processes. Consistent with this idea, genome-wide association studies have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148M as a major player i…
Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function
2001
The heterodimeric peptide transporter associated with antigen processing (TAP) consisting of the subunits TAP1 and TAP2 mediates the transport of cytosolic peptides into the lumen of the endoplasmic reticulum (ER). In order to accurately define domains required for peptide transporter function, a molecular approach based on the construction of a panel of human TAP1 mutants and their expression in TAP1(-/-) cells was employed. The characteristics and biological activity of the various TAP1 mutants were determined, and compared to that of wild-type TAP1 and TAP1(-/-) control cells. All mutant TAP1 proteins were localized in the ER and were capable of forming complexes with the TAP2 subunit. H…
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair
2015
Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …
Genotype and Allele Frequencies of Drug-Metabolizing Enzymes and Drug Transporter Genes Affecting Immunosuppressants in the Spanish White Population
2013
Interpatient variability in drug response can be widely explained by genetically determined differences in metabolizing enzymes, drug transporters, and drug targets, leading to different pharmacokinetic and/or pharmacodynamic behaviors of drugs. Genetic variations affect or do not affect drug responses depending on their influence on protein activity and the relevance of such proteins in the pathway of the drug. Also, the frequency of such genetic variations differs among populations, so the clinical relevance of a specific variation is not the same in all of them. In this study, a panel of 33 single nucleotide polymorphisms in 14 different genes (ABCB1, ABCC2, ABCG2, CYP2B6, CYP2C19, CYP2C…