Search results for "EMBER"
showing 10 items of 549 documents
Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy.
2021
Abstract A series of eleven celastrol derivatives was designed, synthesized, and evaluated for their in vitro cytotoxic activities against six human cancer cell lines (A549, HepG2, HepAD38, PC3, DLD-1 Bax-Bak WT and DKO) and three human normal cells (LO2, BEAS-2B, CCD19Lu). To our knowledge, six derivatives were the first example of dipeptide celastrol derivatives. Among them, compound 3 was the most promising derivative, as it exhibited a remarkable anti-proliferative activity and improved selectivity in liver cancer HepAD38 versus human normal hepatocytes, LO2. Compound 6 showed higher selectivity in liver cancer cells against human normal lung fibroblasts, CCD19Lu cell line. The Ca2+ mob…
4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules
2020
Abstract The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review of literature revealed how such kind of fused heterocycles, coming from natural or synthetic source, are associated with a wide range of biological activities. This review is mainly directed towards the 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle in which all the possible combinations of nitrogen, sulfur and oxygen atoms are present.
European Collective Mark
2014
Previous chapters of Part II dealt with the protection of IGOs at the EU level, i.e. IGOs as unitary rights, through the direct protection system. However, protection of IGOs at the EU level may be ensured not only through the direct protection system, but also through trade mark protection system, namely, through protection as a Community collective mark. That protection is ensured by the Codifying Community Trade Mark Regulation, namely Title VIII containing Arts. 66–74 (previously—Arts. 64–72 of the Community Trade Mark Regulation). From the point of view of the territorial scope, Community collective mark differs from national collective marks of EU Member States. Generally trade mark l…
The Spectacle of Society
2013
Load Carrying Capacity of Glass Columns with Rectangular, T and X Transverse Cross-sections
2014
In this study, the load carrying capacities of glass columns with rectangular, T and X cross-sections having different lengths were calculated. The proposed analytical procedure allows to calculate the load carrying capacity associated with strength of transverse cross-section including local and global flexural and/or torsional buckling phenomenon. Moreover, initial imperfections and time dependant effects, the latter associated with the viscoelastic behaviour of interlayer (PVB), were included in the model as suggested in the literature. Those effects were calculated by introducing the equivalent thickness of glass panels, which takes into account the shear modulus of PVB and the viscolea…
Sine cura. Verso il ri-ciclo dell'architettura del secondo Novecento
2019
Gli argomenti discussi nel saggio interrogano il destino che il Codice dei Beni Culturali (2004- 2011) determina per le opere del secondo Novecento. Nella costruzione del futuro di questi manufatti, che per funzione, tecnologia e cicli d’uso sono spesso segnati dall’obsolescenza e dall’abbandono, le ambiguità e le incongruenze delle attuali procedure legislative sollecitano profondamente il ruolo culturale delle esperienze di ricerca che usano metodologie meta progettuali. Il confronto fra alcuni casi italiani ed altri europei rimarca il ruolo del progetto nella costruzione di una prospettiva di tutela trasformativa per il costruito del secondo Novecento. Nel quadro di azione marcato dall’o…
A Fuzzy Adaptive Controller for an Ambient Intelligence Scenario
2014
The definition of effective energy saving strategies capable of satisfying users’ requirements for environmental wellness is a complex task that requires the definition of well-tuned optimization algorithms. Sensory information depends on the environments observed, hence the model adopted to describe it should be adaptive and dynamic. This chapter presents a methodology for the tuning of a fuzzy controller capable of minimizing energy consumption while maximizing the users comfort in an Ambient Intelligence Scenario. A meta-heuristic search algorithm produces different sets of fuzzy rules depending on the needs of the system. An ontology has been developed to describe the configurations of …
Il caso Mortier c. Belgique. L’eutanasia conseguente a sofferenze psichiche
2023
Il saggio esamina la pronuncia della Corte Europea dei Diritti dell'uomo sul caso Mortier c. Belgio ed evidenzia lo scivolamento della giurisprudenza europea verso la regolamentazione dell'eutanasia per sofferenze anche psichiche negli ordinamenti degli Stati membri.
Louseborne relapsing fever in young migrants, sicily, Italy, july-september 2015
2016
To the Editor: During the early 20th century, at the end of World War I, and during World War II, louseborne relapsing fever (LBRF) caused by Borrelia recurrentis was a major public health problem, especially in eastern Europe and northern Africa (1,2). Currently, poor living conditions, famine, war, and refugee camps are major risk factors for epidemics of LBRF in resource-poor countries, such as those in the Horn of Africa (3,4). Increased migration from resource-poor countries and war/violence create new routes for spread of vectorborne diseases. Recently, several cases of LBRF have been reported among asylum seekers from Eritrea in the Netherlands, Switzerland, and Germany (5–8). All of…
Montalembert, Cochin et les États-Unis,
2013
Cet article examine le mythe des États-Unis d'Amérique dans la pensée politique de Montalmbert et Augustin Cochin.