6533b862fe1ef96bd12c76b3

RESEARCH PRODUCT

4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules

Raffa DemetrioFabiana PlesciaBenedetta MaggioGiuseppe Daidone

subject

ScaffoldNitrogenBioactive moleculesAnti-Inflammatory AgentsAntitubercular Agentschemistry.chemical_elementAntineoplastic Agents01 natural sciencesAntioxidants03 medical and health scienceschemistry.chemical_compoundAnti-Infective AgentsDrug DiscoveryAnimalsHumansMoleculeBenzothiazolesQuinazolinoneQuinazolinones030304 developmental biologyPharmacology0303 health sciencesMolecular Structure010405 organic chemistryOrganic ChemistryN-3 substituted-4-(3H)-quinazolinones five membered heterocycle bioactive systemGeneral MedicineSettore CHIM/08 - Chimica FarmaceuticaSulfurCombinatorial chemistryBronchodilator Agents0104 chemical sciencesOxygenThiazolesOxygen atomchemistryAnticonvulsantsSulfur

description

Abstract The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review of literature revealed how such kind of fused heterocycles, coming from natural or synthetic source, are associated with a wide range of biological activities. This review is mainly directed towards the 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle in which all the possible combinations of nitrogen, sulfur and oxygen atoms are present.

yearjournalcountryeditionlanguage
2020-06-03European Journal of Medicinal Chemistry
https://doi.org/10.1016/j.ejmech.2020.113070