Search results for "EMBER"

Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.

2000

The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …

Journal of Economics and Management Research, Vol.9

2020

Sex composition and group climate: A group actor−partner interdependence analysis.

2013

There is a lack of research examining how the proportion of women and men in a group effects both the group member’s perception of group climate and the aggregated perceptions of group climate for the other group members. We adapted the group actor–partner interdependence model (GAPIM; Kenny & Garcia, 2012) to examine how the perception of the group’s climate by a group member and by the other group members are related to the group member’s sex and the sex of the other group members. In addition, we examined how similar the group member’s sex was to the sex of the other group members by analyzing the interaction between the two sex variables. A total of 110 Italian graduate students (96 wom…

Interventions for Family Members and Carers of Patients with Borderline Personality Disorder: A Systematic Review.

2020

Carers of patients with borderline personality disorder (BPD) experience high levels of distress. Several studies have been carried out on interventions designed to decrease their burden. However, the evidence from these studies has not been summarized. The objective of this work is to explore the clinical utility of interventions developed for family members of patients with BPD. A systematic review was conducted following the PRISMA guidelines (registration number CRD42018107318), including psychological interventions focused on relatives of patients with BPD. The following databases were used: PsycINFO, PubMed, EBSCOhost, and Web of Science. Two independent researchers reviewed the studi…

Young children in day and night care : negotiating and constructing belonging during daily arrivals

2016

The paper aims at understanding the processes related to young children's belonging during daily arrivals at day and night care. Two aspects of a child's belonging are considered: membership and sense of belonging. Data were gathered by ethnographic observation of 8 children aged from 20 to 36 months in two Finnish day care centres offering day and night care. Arrival episodes taking place at different times of day were analysed qualitatively based on the children's actions and expressions. During these episodes, the children negotiated and constructed their belonging by interacting with adults, peers and material objects. These interactions took place within varying social and material sur…

EU Communication in the Member States: Comparative Analysis of Finnish and Italian Communication Strategies

2008

The aim of this paper is to analyze the information and communication policies and strategies developed by the European Union between 2001 and 2006 and their implementation in two member states, namely, Finland and Italy, from a public relations perspective. Six EU information and communication policies are presented, and it is discussed whether or not these policies affect the communication actions of the two selected member states and how these states have implemented them. The results indicate that EU communication strategies during this period were very similar in both countries and not sufficiently tailored to their individual needs. The study is based on a content analysis of EU docum…

La dinámica afiliativa sindical y las trayectorias de sus miembros

2013

Este texto recoge los primeros resultados del Proyecto trianual de Investigación Fundamental no orientada Ref. CSO2010-17962, aprobado por el Ministerio de Ciencia e Innovación (Convocatoria 2010) y del que soy investigadora principal. Dicho Proyecto de I+D, que lleva por título La construcción política del evangelismo gitano: Iglesias, federaciones y nuevos actores políticos, cuenta con la participación formal de la Dra. Teresa San Román Espinosa, catedrática de Antropología Social de la Universidad Autónoma de Barcelona Background of INCASI Project H2020-MSCA-RISE-2015 GA 691004. WP1: Compilation Este texto analiza la dinámica afiliativa de altas y bajas de los sindicatos españoles a part…

How Brexit affects EU external action: The UK’s legacy in European international cooperation

2018

Abstract What exactly Brexit means for British engagement in European external affairs and development cooperation, is highly unclear, while its potential impact is considerable. After the general election in the UK on 8 June 2017, uncertainty regarding the direction, process and timing of the Brexit negotiations and the risk of a disorderly separation have risen further. The government position of a ‘hard Brexit’ seems no longer to be carved in stone. Yet, given the expected – total or partial – withdrawal of a major EU member state, like any area of EU politics, also European development policy faces a number of challenges: short-term problems regarding existing legal obligations, looming…

On Trojan Horses and revolving doors: Assessing the autonomy of national officials in the European Commission

2014

National officials working in international bureaucracies regularly invoke the fear that member states strategically use such officials for influencing decision making and agenda-setting to their advantage. This article theoretically analyses conditions under which the autonomy of national civil servants in international bureaucracies might become compromised. The ensuing predictions are then tested using a unique survey among seconded national experts (SNEs) in the European Commission (N ≈ 400). Finally, evaluating the characteristics linked to reduced autonomy among SNEs in the Commission, the article illustrates that these officials are, in practice, likely to be relatively independent from …

Kinetic Properties of Cl−Uptake Mediated by Na+-Dependent K+-2Cl−Cotransport in Immature Rat Neocortical Neurons

2007

GABA, the main inhibitory neurotransmitter in the adult nervous system, evokes depolarizing membrane responses in immature neurons, which are crucial for the generation of early network activity. Although it is well accepted that depolarizing GABA actions are caused by an elevated intracellular Cl−concentration ([Cl−]i), the mechanisms of Cl−accumulation in immature neurons are still a matter of debate. Using patch-clamp, microfluorimetric, immunohistochemical, and molecular biological approaches, we studied the mechanism of Cl−uptake in Cajal-Retzius (CR) cells of immature [postnatal day 0 (P0) to P3] rat neocortex. Gramicidin-perforated patch-clamp and 6-methoxy-N-ethylquinolinium-microfl…