Search results for "EMBER"

showing 10 items of 549 documents

Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand.

2014

Abstract Ethnopharmacological relevance Thai medicine has a long tradition of tonifying medicinal plants. In the present investigation, we studied the flower extracts of Jasminum sambac, Mammea siamensis, Mesua ferrea, Michelia alba, Mimusops elengi, and Nelumbo nucifera and speculated that these plants might influence metabolism and substance flow in the body. Materials and methods Isolation of porcine brain capillary endothelial cells (PBCECs) as well as multidrug-resistance CEM/ADR5000 leukemia cells, MDA-M;B-231 breast cancer, U-251 brain tumor, and HCT-116 colon cancer cells were used. The calcein-acetoxymethylester (AM) assay was used to measure inhibition of P-glycoprotein transport.…

SwineMesua ferreaMimusops elengiFlowersPharmacologyBlood–brain barrierchemistry.chemical_compoundCell Line TumorNeoplasmsDrug DiscoverymedicineAnimalsHumansATP Binding Cassette Transporter Subfamily B Member 1CytotoxicityP-glycoproteinPharmacologyMedicine East Asian TraditionalPlants MedicinalbiologyTraditional medicinePlant ExtractsMammeaBrainEndothelial Cellsmedicine.diseasebiology.organism_classificationThailandAntineoplastic Agents PhytogenicDrug Resistance MultipleLeukemiamedicine.anatomical_structurechemistryBlood-Brain BarrierDrug Resistance Neoplasmbiology.proteinEndothelium VascularGrowth inhibitionJournal of ethnopharmacology
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Evolution of the taste of a bitter camembert cheese during ripening : characterization of a matrix effect

2001

The objective of this study was to characterize the effect of ripening on the taste of a typically bitter Camembert cheese. The first step was to select a typically bitter cheese among several products obtained by different processes supposed to enhance this taste defect. Second, the evolution of cheese taste during ripening was characterized from a sensory point of view. Finally, the relative impact of fat, proteins, and water-soluble molecules on cheese taste was determined by using omission tests performed on a reconstituted cheese. These omission tests showed that cheese taste resulted mainly from the gustatory properties of water-soluble molecules but was modulated by a matrix effect d…

TasteFood HandlingOrganolepticCheese ripening01 natural sciencesSensory analysis0404 agricultural biotechnologyCheese[SDV.IDA]Life Sciences [q-bio]/Food engineeringFood scienceComputingMilieux_MISCELLANEOUSChemistry010401 analytical chemistryWaterfood and beveragesRipening04 agricultural and veterinary sciencesGeneral Chemistry[SDV.IDA] Life Sciences [q-bio]/Food engineeringCamembert cheeseBitter taste040401 food science0104 chemical sciencesSolubilityTasteGeneral Agricultural and Biological Sciences
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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The emotional timeline of September 11, 2001.

2010

Time FactorsInjury controlAccident preventionmedia_common.quotation_subjectWritingApplied psychologyEmotionsPoison controlAngerAngerAnxietyAdaptation PsychologicalmedicineHumansGeneral Psychologymedia_commonPsycholinguisticsCommunicationTimelinemedicine.diseaseSemanticsGriefMedical emergencyGriefSeptember 11 Terrorist AttacksPsychologyCell PhonePrejudiceSoftwarePsychological science
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Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1

1999

0014-2956 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't; A PCR approach has been used to isolate, from Bombyx mori, a cDNA encoding a novel orphan receptor (GRF) that is most closely related to Bombyx betaFTZ-F1 and to the vertebrate germ cell nuclear factor. The major GRF mRNA is detected in most tissues as an 8-kb transcript whose amount follows the circulating ecdysteroid concentration with a delay. The expression pattern of GRF is similar to that of the Bombyx homologue of the Drosophila early-late gene DHR3, and precedes that of betaFTZ-F1 in all stages and tissues examined. The GRF protein is thus likely to be required in many tissues, but in a temporally …

Transcription GeneticReceptors Cytoplasmic and NuclearFushi Tarazu Transcription FactorsSequence HomologyGenes InsectDevelopmental/drug effectsSteroidogenic Factor 1BiochemistryBombyx/*chemistry/growth & developmentDNA/*metabolismNuclear Receptor Subfamily 6 Group A Member 1ReceptorsCloning MolecularReceptorRegulation of gene expressionOrphan receptorbiologyGene Expression Regulation DevelopmentalDNA-Binding ProteinsEcdysterone/pharmacologyAmino AcidEcdysteroneInsect Proteins/genetics/*isolation & purification/metabolismInsect ProteinsRecombinant Fusion Proteins/metabolismTranscriptionProtein StructureRecombinant Fusion ProteinsGerm cell nuclear factorMolecular Sequence DataGeneticComplementary DNAAnimalsAmino Acid SequenceBinding siteBombyxHomeodomain ProteinsBinding Sitespurification/metabolismSequence Homology Amino AcidBase SequencefungiMolecularCytoplasmic and Nuclear/chemistryDNABombyxbiology.organism_classificationMolecular biologyProtein Structure TertiaryTranscription Factors/chemistry/genetics/*isolation &Nuclear receptorGene Expression RegulationGenesDNA-Binding Proteins/chemistry/genetics/*isolation &InsectSequence AlignmentTertiaryTranscription FactorsCloning
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In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

2010

The potent anti-tumour activities of gamma delta T cells have prompted the development of protocols in which gamma delta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a V gamma 9V delta 2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of V gamma 9V delta 2 T …

Translational Studiesmedicine.medical_treatmentLymphocyte ActivationZoledronic AcidMetastasisTNF-Related Apoptosis-Inducing LigandProstate cancerT-Lymphocyte SubsetsImmunology and AllergyMedicineDiphosphonatesRemission InductionEsterasesImidazolesReceptors Antigen T-Cell gamma-deltaMiddle AgedMetastatic breast cancerTreatment Outcomemedicine.anatomical_structureDisease ProgressionCytokinesFemaleImmunotherapyBreast diseaseChemokinesT cellImmunologyBreast NeoplasmsInterferon-gammaHemiterpenesOrganophosphorus CompoundsBreast cancerAdjuvants ImmunologicVgamma9Vdelta2 T cells Zoledronate interleukin-2advanced breast cancer patientsHumansLymphocyte CountAgedCell ProliferationSalvage Therapybusiness.industryLysineMucin-1CancerImmunotherapymedicine.diseaseTumor Necrosis Factor Receptor Superfamily Member 7ImmunologyInterleukin-2Leukocyte Common Antigensbusiness
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La creación de un nuevo orden público europeo en materia de privacidad como presupuesto para su garantía integral

2021

espanolLa normativa reciente en materia de proteccion de datos asi como los pronunciamientos del Tribunal de Justicia de la Union Europea en la cuestion y del Tribunal Europeo de Derechos Humanos sobre el derecho a la vida privada, refuerzan la idea de la existencia de un orden publico europeo distinto del orden publico interno e internacional de cada Estado miembro. En este sentido, se ha venido conformando una estrategia comunitaria y un orden publico europeo en torno a la concepcion de la vida intima y familiar y, en particular, al propio concepto de privacidad, cuyo alcance y significacion difiere de la conceptualizacion que, sobre estos elementos, se ha venido realizando por la doctrin…

TribunalLegal doctrineMember statesPolitical scienceCommon lawPublic policyLawHumanitiesFamily lifeEuropean court of justiceCUADERNOS DE DERECHO TRANSNACIONAL
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El laberinto de la sucesión de estados respecto de los tratados internacionales sobre derechos humanos

2021

This Article analyses the effects of succession of States in respect of international treaties on human rights. This is a matter not codified by the Vienna Convention on Succession of States in respect of Treaties. We have to bear in mind that human rights treaties have been adopted by international organisations, which have developed their own practice both for the succession of States as States Members of an international organisation and for the succession of States as Contracting Parties to treaties that the United Nations, the Council of Europe or the European Union have adopted in the field of human rights.

Valentín Enrique This Article analyses the effects of succession of States in respect of international treaties on human rights. This is a matter not codified by the Vienna Convention on Succession of States in respect of Treaties. We have to bear in mind that human rights treaties have been adopted by international organisationswhich have developed their own practice both for the succession of States as States Members of an international organisation and for the succession of States as Contracting Parties to treaties that the United Nations2070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055235 El laberinto de la sucesión de estados respecto de los tratados internacionales sobre derechos humanos Bou Franchtreaties on human rights 690 731UNESCO::CIENCIAS JURÍDICAStratados de derechos humanosinternational treatiesSuccession of Statesthe Council of Europe or the European Union have adopted in the field of human rights. Sucesión de Estadostratados internacionales
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The impact of foreign trade on the Netherlands' real CO2 emissions

2019

Aim: CO2 emissions and the related climate change are a global problem, where the direct impact of actions of individual countries depends on their total share in CO2 emissions. In order to assess the potential for policy measures, the openness of an economy, and the related import and export and their impacts on emissions should be considered. The aim of this paper is the attempt to show the real CO2 emissions of the Netherlands as well as the impact of its trade on CO2 emissions in other countries in the world and in the EU in 2015.Design / Research methods: This study was conducted on the group of countries that are the major emitters of CO2 in the world including most of the EU members.…

Value (ethics)business.industryMember statesthe NetherlandsGlobal problemClimate changeclimate policyInternational tradeCO2 emissionsEnergy policyexports and importsOrder (exchange)Openness to experienceddc:330EU energy policymedia_common.cataloged_instanceEuropean unionbusinessmedia_common
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