Search results for "EMC"
showing 10 items of 369 documents
PDGFRα-Positive B Cells Are Neural Stem Cells in the Adult SVZ that Form Glioma-like Growths in Response to Increased PDGF Signaling
2006
Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRalpha in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias wi…
Patterns of Bladder Preservation Therapy Utilization for Muscle-Invasive Bladder Cancer
2016
Background: Trimodality bladder preservation therapy (BPT) in muscle invasive bladder cancer (MIBC) includes a maximal transurethral resection followed by concurrent chemoradiotherapy as an alternative to radical cystectomy (RC) in appropriately selected patients, or as a treatment option in non-cystectomy candidates. Several chemotherapy regimens can be used in BPT, but little is known about current practice patterns. Objective: To describe utilization patterns of BPT and associated survival outcomes in MIBC. Methods: Data were collected from the Retrospective International Study of Cancers of the Urothelial Tract (RISC), a database of 3,024 consecutive patients from 29 international acade…
NEONAX trial: Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer, a phase II study of the AI…
2019
4128 Background: Survival in pancreatic cancer (PDAC) is still poor even after curatively intended resection. Perioperative treatment approaches improve outcome in various tumor entities. Data on perioperative treatment in resectable PDAC are limited and there is a debate whether neoadjuvant treatment might impair subsequent surgery by adding perioperative morbidity or mortality. Methods: NEONAX is a randomized phase II study (planned 166 patients) of perioperative gemcitabine/nab-paclitaxel (Arm A: 2 pre- and 4 post-operative cycles, Arm B: 6 cycles adjuvant) for patients with primarily resectable PDAC. Primary objective is DFS at 18 months after randomization. Secondary objectives are 3-…
Formation of an interlocked double-chain from an organic-inorganic [2]rotaxane.
2019
Here we show that a structure containing a polymeric interlocking daisy chain is obtained from the reaction of an inorganic–organic [2]rotaxane [HB{CrIII7NiII(μ-F)8(O2CtBu)16}], where B is an organic thread terminated with a bi-pyridyl unit, with an oxo-centered metal carboxylate triangle [FeIII2CoII(μ3-O)(O2CtBu)6(HO2CtBu)3].
Configurations of the Interactive Use of Environmental Management Control
2013
This paper explores the use of interactive environmental management control. In order to do this, a theoretical model is designed drawing on the framework of Simons (1995) and instrumental stakeholder theory. This model defines three dimensions of interactive control: forms of interactivity (vertical, horizontal, external), frequencies of interactivity (high, medium, low) and decision levels (strategic, tactical, operational). Four typical configurations emerge from application of the model to empirical data from ten case studies: eco-designers, eco-institutionals, eco-managers and eco-educators. These configurations show the diverse roles of interactive environmental management control in …
Molecular Characterization of a Long Term Survivor Double Metastatic Non Small Sell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gef…
2019
Management of multiple primary cancers, a not so infrequent event in oncology practice, is a critical issue due to the lack of literature . In this study, we reported the case of a patient with metachronous double metastatic non small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) who received gefitinib in combination with gemcitabine plus nab-paclitaxel and with mFOLFOX6 in first and second line, respectively. She achieved a progression free survival and an overall survival (OS) of 28 months for NSCLC and PFS-1 and OS of 20 and 13 months, respectively for PDAC. Moreover, the combination of gefitinib and chemotherapies treatments displayed a good safety profile. Given …
Measurement of the semileptonic decaysB¯→Dτ−ν¯τandB¯→D*τ−ν¯τ
2009
We present measurements of the semileptonic decays B{sup -}{yields}D{sup 0}{tau}{sup -}{nu}{sub {tau}}, B{sup -}{yields}D*{sup 0}{tau}{sup -}{nu}{sub {tau}}, B{sup 0}{yields}D{sup +}{tau}{sup -}{nu}{sub {tau}}, and B{sup 0}{yields}D*{sup +}{tau}{sup -}{nu}{sub {tau}}, which are sensitive to non-standard model amplitudes in certain scenarios. The data sample consists of 232x10{sup 6} {upsilon}(4S){yields}BB decays collected with the BABAR detector at the PEP-II e{sup +}e{sup -} collider. We select events with a D or D* meson and a light lepton (l=e or {mu}) recoiling against a fully reconstructed B meson. We perform a fit to the joint distribution of lepton momentum and missing mass squared …
Serotypes of Aggregatibacter actinomycetemcomitans in relation to periodontal status and geographic origin of individuals-a review of the literature
2014
Objectives: Several studies have focused on the relationship among serotype distribution, ethnical status and geo - graphic populations, and periodontal conditions. Studies that have investigated the prevalence and the distribution of A. actinomycetemcomitans serotypes and the relation between the different serotypes of the bacterium and periodontal status were reviewed. Material and Methods: A systematic literature search for publications regarding the distribution of A. actinomyc - etemcomitans serotypes in subgingival samples of periodontitis patients and periodontally healthy subjects by employing polymerase chain reaction (PCR) was conducted. Results: From the 85 studies identified in …
The set of conjugacy class sizes of a finite group does not determine its solvability
2014
Abstract We find a pair of groups, one solvable and the other non-solvable, with the same set of conjugacy class sizes.
Influence of biochar on the physical, chemical and retention properties of an amended sandy soil
2017
Soil porosity plays an important role in soil-water retention and water availability to crops, potentially affecting both agricultural practices and environmental sustainability. The pore structure controls fluid flow and transport through the soil, as well as the relationship between the properties of individual minerals and plants. Moreover, the anthropogenic pressure on soil properties has produced numerous sites with extensive desertification process close to residential areas. Biochar (biologically derived charcoal) is produced by pyrolysis of biomasses under low oxygen conditions, and it can be applied for recycling organic waste in soils and increase soil fertility, improving soil st…