Search results for "EMU"

Performance and modelling of retention in microemulsion liquid chromatography

2020

Abstract The capability of liquid chromatography with microemulsions (MEs) as mobile phases was studied for the analysis of four parabens (butylparaben, ethylparaben, methylparaben, and propylparaben) and seven β-adrenoceptor antagonists (acebutolol, atenolol, carteolol, metoprolol, oxprenolol, propranolol, and timolol). MEs were formed by mixing aqueous solutions of the anionic surfactant sodium dodecyl sulphate, the alcohol 1-butanol that played the role of co-surfactant, and octane as oil. In order to guarantee the formation of stable MEs, a preliminary study was carried out to determine the appropriate ranges of concentrations of the three components. For this purpose, mixtures of varia…

Executive remuneration determinants: New evidence from meta-analysis

2019

This meta-analysis takes stock of 121 C.E.O. pay studies published between 1998 and 2018 with the objective of identifying the main drivers of C.E.O. pay from a global perspective and contributing to the agency vs managerial debate on this ground. The meta-results disclose a positive C.E.O. pay–performance correlation (the highest correlation coefficient corresponds to Earnings per share with a 34%) as the agency theory prescribes and the governance policies promote. However, firm size still predominates as the main driver of C.E.O. pay (correlation coefficient is around 44%) according to managerial premises. Moreover, our results reconcile both approaches because results of the meta-regres…

Fatty Acid Transporter CD36 Mediates Hypothalamic Effect of Fatty Acids on Food Intake in Rats

2013

Subject Areas: carotid arteries; emulsions; fatty acids; gene expression; heparin; hypothalamus; neurons; oxidation.; International audience; Variations in plasma fatty acid (FA) concentrations are detected by FA sensing neurons in specific brain areas such as the hypothalamus. These neurons play a physiological role in the control of food intake and the regulation of hepatic glucose production. Le Foll et al. previously showed in vitro that at least 50% of the FA sensing in ventromedial hypothalamic (VMH) neurons is attributable to the interaction of long chain FA with FA translocase/CD36 (CD36). The present work assessed whether in vivo effects of hypothalamic FA sensing might be partly m…

Critical Experiences with Sport and Wellness Technology Digital Coach : A Study among University Students with Low Levels of Physical Activity

2019

University age students have been found to be in a high risk of disengagement with physical activity and therefore exercise promotion to this target group is important. Since today’s students are familiar with different kinds of digital technology, it is worth including personal wellness devices in physical activity promotion. This study explores critical experiences occurring during the implementation phase of a sport and wellness technology digital coach among university students with low or sedentary physical activity level. This study uses qualitative methods and is based on a thematic analysis of 30 interviews combined with the critical incident technique. The study reveals the experie…

"Tässä ryhmässä olen aika hyvä" : ekologinen näkökulma kielenoppijaidentiteetteihin peruskoulun viidennen ja kuudennen luokan englannin opetuksessa

2012

Christianity and digital culture : analysis of users' experiences of the christian social networking site in Taiwan - Walei

2011

Social Networking Sites (SNSs) have been a popular phenomenon worldwide, while religion in Computer Mediated Communication (CMC) studies has gained more academic attention. Walei as a pioneering social networking site is founded by a group of Protestant Christians targeting at the youth in Taiwan, and it exemplifies religious application on the Internet. This thesis investigates what role such a website plays both for its users and against its competition, particularly in the non-Christian cultural context. Using online interviews with nine users of Walei, how the interactivity affects Christian users‟ religious identity and the impression of non-Christian users toward Christianity is explo…

"Nykyään sitä on oppinut arvostaa" : nuorten, joilla on CP- vamma, kokemuksia pitkäaikaisesta fysioterapiasta

2012

Pro gradu- tutkimukseni tarkoituksena on ymmärtää ja kuvata nuorten, joilla on CP- vamma, kokemuksia pitkäaikaisesta fysioterapiasta fenomenologis- hermeneuttisen tutkimusasetelman kautta. Tutkimus liittyy laajempaan Jyväskylän yliopiston koordinoimaan Potilasohjaus fysioterapiassa – projektiin ja sillä on tutkimuslupa HUS:n eettiseltä toimikunnalta. Tutkimukseen osallistui 10 nuorta, joilla on ollut fysioterapiaa pienestä lapsesta lähtien, 16-22 -vuotta. Aineisto kerättiin avoimien yksilöllisten haastattelujen avulla ja analysoitiin Spiegelbergin (1982) ja Laineen (2010) aineistoanalyysimenetelmän kautta. Tutkimukseen osallistuneiden nuorten merkityskokonaisuuksina ilmenivät: fysioterapia …

Aqueous two-phase system cold-set gelation using natural and recombinant probiotic lactic acid bacteria as a gelling agent

2016

The present study aimed to entrap probiotic lactic acid bacteria (LAB) in a sodium alginate and sodium caseinate aqueous two-phase gel system. The natural acidifying properties of two therapeutic probiotic LAB were exploited to liberate calcium ions progressively from calcium carbonate (CaCO3), which caused the gelation of the co-existing phases. Bi-biopolymeric matrix gelation of GDL/CaCO3 or LAB/CaCO3 was monitored by dynamic rheological measurements, and the final gels were characterized by frequency dependence measurements and confocal laser scanning microscopy. Weak to strong gels were formed with an elastic modulus G' from 10 to 1.000Pa, respectively. After cold-set gelation of our sy…

Expression of DNA repair proteins hMSH2, hMSH6, hMLH1,O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells wit…

1999

Malignant melanoma is well known for its primary unresponsiveness to chemotherapy. The mechanisms conferring this intrinsic resistance are unclear. In this study, we investigated the role of genes involved in DNA repair in a panel of human melanoma cell variants exhibiting low and high levels of resistance to 4 commonly used drugs in melanoma treatment, i.e., vindesine, etoposide, fotemustine and cisplatin. We show that in melanoma cells exhibiting resistance to cisplatin, etoposide and vindesine, the nuclear content of each of the DNA mismatch repair (MMR) proteins hMLH1, hMSH2 and hMSH6 was reduced by 30–70%. A decreased expression level of up to 80% of mRNAs encoding hMLH1 and hMSH2 was …

Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene mgmt

2001

Acquired resistance to antineoplastic agents is a frequent obstacle in tumor therapy. Malignant melanoma cells are particularly well known for their unresponsiveness to chemotherapy; only about 30% of tumors exhibit a transient clinical response to treatment. In our study, we investigated the molecular mechanism of acquired resistance of melanoma cells (MeWo) to the chloroethylating drug fotemustine. Determination of O6-methylguanine-DNA methyltransferase (MGMT) activity showed that MeWo cells that acquired resistance to fotemustine upon repeated treatment with the drug display high MGMT activity, whereas the parental cell line had no detectable MGMT. The resistant cell lines exhibit cross-…