Search results for "ENO.1"

showing 10 items of 27 documents

Excess electronic recoil events in XENON1T

2020

We report results from searches for new physics with low-energy electronic recoil data recorded with the XENON1T detector. With an exposure of 0.65 t-y and an unprecedentedly low background rate of $76\pm2$ events/(t y keV) between 1 and 30 keV, the data enables sensitive searches for solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter. An excess over known backgrounds is observed at low energies and most prominent between 2 and 3 keV. The solar axion model has a 3.4$\sigma$ significance, and a 3D 90% confidence surface is reported for axion couplings to electrons, photons, and nucleons. This surface is inscribed in the cuboid defined by $g_{ae}<3.8 \times 10^{-12}$,…

xenon: targetaxionssolar axionmagnetic momentdimension: 3neutrino: solarPhysics beyond the Standard ModelSolar neutrinodark matter: direct detection01 natural sciences7. Clean energyHigh Energy Physics - ExperimentDark matter direct detection axionHigh Energy Physics - Experiment (hep-ex)neutrinoXENONHigh Energy Physics - Phenomenology (hep-ph)background: lowRecoilelectron: recoil[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]beta-raysParticle Physics Experimentscoupling: (axion 2electron)multi-purpose particle detectornuclear instrumentationComputingMilieux_MISCELLANEOUSinstrumentationPhysicsxenon: liquidboson: dark matteraxion 2nucleontritiumnew physics: search forsemileptonic decayboson: vectortensionneutrino: magnetic momentHigh Energy Physics - Phenomenologyaxion 2photonlow backgroundbosonNeutrinoionizing radiationNucleonAstrophysics - Cosmology and Nongalactic AstrophysicsCosmology and Nongalactic Astrophysics (astro-ph.CO)dark matter detectorelectronic recoilElectron captureXENON1T detectorDark matterlow-energy electronic recoil dataFOS: Physical sciences[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]dark matterNONuclear physicsPE2_2PE2_1tritium: semileptonic decay0103 physical sciencessolar axion modelsurface[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]axion: couplingPE2_4010306 general physicspseudoscalarAxiondark matter: vectordark matter XENON1T detector electronic recoilsolar neutrinodetectorDark Matter Axions Beta Decay Liquid Xenon TPC010308 nuclear & particles physicsaxion 2electroncoupling: (axion 2nucleon)dark matter: detectormodel: axionGran Sassometrology[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph]axionstellar constraintscoupling: (axion 2photon)High Energy Physics::Experimentparticle dark matterdirect detectionbeta decayaxion: solar[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]experimental results
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Vaccination with ENO1 DNA Prolongs Survival of Genetically Engineered Mice with Pancreatic Cancer

2013

Background & Aims Pancreatic ductal adenocarcinoma (PDA) is an aggressive tumor, and patients typically present with late-stage disease; rates of 5-year survival after pancreaticoduodenectomy are low. Antibodies against α-enolase (ENO1), a glycolytic enzyme, are detected in more than 60% of patients with PDA, and ENO1-specific T cells inhibit the growth of human pancreatic xenograft tumors in mice. We investigated whether an ENO1 DNA vaccine elicits antitumor immune responses and prolongs survival of mice that spontaneously develop autochthonous, lethal pancreatic carcinomas. Methods We injected and electroporated a plasmid encoding ENO1 (or a control plasmid) into Kras G12D /Cre (KC) mice …

medicine.medical_treatmentDNA Vaccine; Enolase; Parnceratic cancer; Transgeneic miceEnolasegenetically engineered miceceEnzyme-Linked Immunosorbent AssayTransgeneic miceDNA vaccination03 medical and health sciencesMice0302 clinical medicineImmune systemPancreatic cancerGenetic modelmedicineVaccines DNADNA VaccineAnimalsSurvival rate030304 developmental biology0303 health sciencesImmunity CellularHepatologybiologyENO.1; DNA Vaccine; genetically engineered miceceVaccinationGastroenterologyParnceratic cancerImmunotherapyNeoplasms Experimentalmedicine.diseaseImmunohistochemistryMice Mutant Strains3. Good healthPancreatic NeoplasmsSurvival RateSettore BIO/18 - GeneticaTumor progression030220 oncology & carcinogenesisPhosphopyruvate HydrataseImmunologybiology.proteinAntibodyENO.1Carcinoma Pancreatic Ductal
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CCDC 1995028: Experimental Crystal Structure Determination

2020

Related Article: Justin J. Dressler, Joshua E. Barker, Lucas J. Karas, Hannah E. Hashimoto, Ryohei Kishi, Lev N. Zakharov, Samantha N. MacMillan, Carlos J. Gomez-Garcia, Masayoshi Nakano, Judy I. Wu, Michael M. Haley|2020|J.Org.Chem.|85|10846|doi:10.1021/acs.joc.0c01387

Space GroupCrystallography714-bis(246-trimethylphenyl)-512-dibenzo[dd']s-indaceno[12-b:56-b']bisthiophene-551212-tetrone chloroform solvateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1014064: Experimental Crystal Structure Determination

2014

Related Article: Yann Bernhard, Pascale Winckler, Remi Chassagnon, Philippe Richard, Élodie Gigot, Jean-Marie Perrier-Cornet, Richard A. Decréau|2014|Chem.Commun.|50|13975|doi:10.1039/C4CC05503A

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters4-(14dH-59101414e15-hexaaza-14d-boradibenzo[23:56]-s-indaceno[187-bcde]fluoranthen-14d-yloxy)anilineExperimental 3D Coordinates
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CCDC 1949614: Experimental Crystal Structure Determination

2020

Related Article: Justin J. Dressler, Abel Cárdenas Valdivia, Ryohei Kishi, Gabriel E. Rudebusch, Austin M. Ventura, Brian E. Chastain, Carlos J. Gómez-García, Lev N. Zakharov, Masayoshi Nakano, Juan Casado, Michael M. Haley|2020|Cell Press: Chem|6|1353|doi:10.1016/j.chempr.2020.02.010

{[1020-bis(246-trimethylphenyl)bisbenzo[45]indeno[12-b:1'2'-i]anthracene-818-diyl]bis(ethyne-21-diyl)}bis[tri-isopropylsilane]Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1408336: Experimental Crystal Structure Determination

2017

Related Article: Debin Xia, Xin Guo, Manfred Wagner, Martin Baumgarten, Dieter Schollmeyer, Klaus Müllen|2017|Cryst.Growth Des.|17|2816|doi:10.1021/acs.cgd.7b00272

Space GroupCrystallographyCrystal SystemCrystal Structure33'99'-tetra-t-butyl-66'-spirobi[diindeno[12-b:2'1'-h]fluorene]-1212'1515'-tetrone unknown solvateCell ParametersExperimental 3D Coordinates
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CCDC 1949613: Experimental Crystal Structure Determination

2020

Related Article: Justin J. Dressler, Abel Cárdenas Valdivia, Ryohei Kishi, Gabriel E. Rudebusch, Austin M. Ventura, Brian E. Chastain, Carlos J. Gómez-García, Lev N. Zakharov, Masayoshi Nakano, Juan Casado, Michael M. Haley|2020|Cell Press: Chem|6|1353|doi:10.1016/j.chempr.2020.02.010

Space GroupCrystallography{[919-bis(246-trimethylphenyl)bisbenzo[56]indeno[12-b:1'2'-i]anthracene-717-diyl]bis(ethyne-21-diyl)}bis[tri-isopropylsilane]Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1456530: Experimental Crystal Structure Determination

2016

Related Article: Yann Bernhard, Elodie Gigot, Victor Goncalves, Mathieu Moreau, Nicolas Sok, Philippe Richard, Richard A. Decréau|2016|Org.Biomol.Chem.|14|4511|doi:10.1039/C6OB00530F

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters14d-(4-(Prop-2-yn-1-yloxy)phenoxy)-14dH-59Λ51014Λ514elambda515-hexaaza-14dlambda5-boradibenzo[23:56]-s-indaceno[187-bcde]fluorantheneExperimental 3D Coordinates
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CCDC 843819: Experimental Crystal Structure Determination

2012

Related Article: H.Isla, B.Grimm, E.M.Perez, M.R.Torres, M.A.Herranz, R.Viruela, J.Arago, E.Orti, D.M.Guldi, N.Martin|2012|Chemical Science|3|498|doi:10.1039/c1sc00669j

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1015-bis(13-dithiol-2-ylidene)-1015-dihydro-5H-diindeno[12-a:1'2'-c]fluoren-5-oneExperimental 3D Coordinates
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CCDC 623710: Experimental Crystal Structure Determination

2007

Related Article: E.M.Perez, M.Sierra, L.Sanchez, M.R.Torres, R.Viruela, P.M.Viruela, E.Orti, N.Martin|2007|Angew.Chem.,Int.Ed.|46|1847|doi:10.1002/anie.200604327

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters22'2''-(5H-diindeno[12-a:1'2'-c]fluorene-51015-triylidene)tris(13-dithiole) chloroform solvateExperimental 3D Coordinates
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