Search results for "ENaC"
showing 10 items of 307 documents
Good Old-Fashioned Artificial Consciousness and the Intermediate Level Fallacy
2018
Recently, there has been considerable interest and effort to the possibility to design and implement conscious robots, i.e., the chance that a robot may have subjective experiences. However, typical approaches as the global workspace, information integration, enaction, cognitive mechanisms, embodiment, i.e., the Good Old-Fashioned Artificial Consciousness, henceforth, GOFAC, share the same conceptual framework. In this paper, we discuss GOFAC's basic tenets and their implication for AI and Robotics. In particular, we point out the intermediate level fallacy as the central issue affecting GOFAC. Finally, we outline a possible alternative conceptual framework towards robot consciousness.
Farmacologia de la solifenacina
2010
Departamento de Farmacologia. Facultad de Medicina y Odontologia. Universidad de Valencia. Valencia. Espana.Resumen.- Los antimuscarinicos son los farmacos de primera eleccion para el tratamiento del sindrome de vejiga hiperactiva y su relacion beneficio/riesgo depen-de en gran medida de la selectividad por los distintos subtipos de receptores muscarinicos. Solifenacina es el antimuscarinico que muestra mayor selectividad por los receptores M3 vesicales, lo que puede traducirse en una menor incidencia de reacciones adversas relacionadas con otros subtipos de receptor. Las vias metabolicas de los antimuscarinicos pueden influir en la eficacia y en la aparicion de interacciones. Solifenacina es …
Rainfall timing and runoff: The influence of the criterion for rain event separation
2016
Abstract Rain is not uniform in time and space in semiarid areas and its distribution is very important for the runoff process. Hydrological studies usually divide rainfall into events. However, defining rain events is complicated, and rain characteristics vary depending on how the events are delimited. Choosing a minimum inter-event time (MIT) is a commonly used criterion. Our hypothesis is that there will be an optimal MIT that explains the maximum part of the variance of the runoff, with time to runoff used as a surrogate. The objective is to establish a procedure in order to decide upon this optimal MIT. We developed regressions between time to runoff (T0) and three descriptive variable…
La continuidad ecológico-ambiental como estrategia de ordenación del territorio
2013
El presente trabajo intenta describir las modalidades a través de las cuales la dimensión ecológico-ambiental puede devenir parte estructurante de la ordenación del territorio, en un contexto como el siciliano, particularmente frágil tanto bajo el perfil de los procesos de fragmentación ambiental en acto, como bajo el de las criticidades de los instrumentos de planificación urbanística y territorial. Las reflexiones que siguen, en particular, intentan traducir en indicaciones concretas y espacialmente territorializadas tales contenidos, a través de la aplicación del tema del proyecto de la continuidad ambiental y de las redes ecológicas en el territorio de la provincia de Trapani. El trabaj…
Graphic proposal for the great hall of the Palace of the Counts of Oliva
2021
[EN] The now-demolished Palace of the Counts of Oliva, in the province of Valencia (Spain), was an outstanding example of late Gothic and early Renaissance architecture and art. Its great hall was particularly impressive, with rich, complex decoration that constituted a cultural milestone linked recently to the ‘Germanías’, or Brotherhoods. Through research conducted in image and document collections, a graphic reproduction of the room has been produced, with special emphasis on its frieze. The procedures and techniques used in this process are examined here, before a final contemplation of the possible uses for these results.
Biosynthesis of beauvericin and enniatins in vitro by wheat Fusarium species and natural grain contamination in an area of central Italy
2015
Contamination of wheat grain by beauvericin (BEA) and enniatins (ENs) is a global emerging mycotoxicological food problem. In this study, strains of Fusarium avenaceum (FA), Fusarium poae (FP), Fusarium equiseti and Fusarium sporotrichioides, all potential BEA and EN producers, isolated from 162 grain samples of durum and soft wheat harvested in 2009 and 2010 collected in an area of central Italy, were preliminarily screened for the presence of the esyn1 gene, encoding the multifunctional enzyme enniatin-synthetase for the detection of potential hexadepsipeptide-producing isolates. All positive isolates were tested for their ability to biosynthesize BEA and ENs in vitro. In addition, all wh…
Isolation and purification of enniatins A, A1, B, B1, produced by Fusarium tricinctum in solid culture, and cytotoxicity effects on Caco-2 cells
2010
Enniatins (ENs) are antibiotic compounds of hexadepsipeptidic structure produced by several strains of Fusarium spp. The ENs A, A(1), B, B-1 were purified from extracts of Fusarium tricinctum grown on a solid medium of corn, by a low pressure liquid chromatography (LPLC) on reverse phase of Amberlite XAD-7 followed by semipreparative LC. The purity and the structure of the isolated compounds were confirmed by LC-MS/MS. The technique of the purification of the fungal extract enabled complete separation of the ENs A, A(1), B, B-1 with a mean purity of 97% for all the compounds. The cytoxicity of the ENs was tested in the cell lines of human origin (epithelial colorectal adenocarcinoma cells, …
Evaluation of Fungistatic Activity of Eight Selected Essential Oils on Four Heterogeneous Fusarium Isolates Obtained from Cereal Grains in Southern P…
2020
The aim of the study was to determine the relationship between the chemical composition of eight commercial essential oils (EsO) (garlic, grapefruit, lemon grass, tea tree, thyme, verbena, cajeput, and Litsea cubeba) and their fungistatic activity in relation to four species of Fusarium: F. avenaceum, F. culmorum, F. graminearum, and F. oxysporum. The species identification of Fusarium isolates was confirmed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. The determination of qualitative and quantitative chemical composition of the EsO was carried out using the gas chromatography&ndash
About the Ambassador Vich Palace s distribution and some thoughts on its patio
2019
[ES] El palacio del Embajador Vich es todavía una de las grandes asignaturas pendientes de la historiografía valenciana. Su patio, reconstruido en el Museo de Bellas Artes de Valencia, ha sido estudiado por diversos autores en las últimas décadas y se ha relacionado con el panorama romano de la época, asumiendo no obstante su autoría local. En cuanto al resto del edificio, apenas se ha tratado sobre él, más allá de algunas interpretaciones basadas en los planos de Tosca y Fortea. En el presente artículo pretendemos contribuir a conocer algo mejor la residencia histórica de los barones de Llaurí a partir de dos inventarios del siglo XVII. Igualmente reflexionaremos sobre algunas incógnitas t…
Two new triterpenoid saponins fromPittosporum senaciaPutterlick (Pittosporaceae)
2012
From the branches of Pittosporum senacia Putterlick (Pittosporaceae), two new triterpenoid saponins, senaciapittosides A and B (1, 2), were isolated. Their structures were elucidated by extensive analysis of one- and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionization mass spectrometry (HR-ESIMS) and chemical evidence as 3-O-[β-d-glucopyranosyl-(1 2)]-[α-l-arabinopyranosyl-(1 3)]-[α-l-arabinofuranosyl-(1 4)]-β-d-glucuronopyranosyl oleanolic acid 28-O-β-d-glucopyranosyl ester (1) and 3-O-[β-d-glucopyranosyl-(1 2)]-[α-l-arabinopyranosyl-(1 3)]-[α-l-arabinofuranosyl-(1 4)]-β-d-glucuronopyranosyl-22-O-α-l-arabinopyranosyl-21-acetoxy R1-barrigen…