Search results for "ERAS"
showing 10 items of 4431 documents
Stress, Professional Lifestyle, and Telomere Biology in Elite Athletes: A Growing Trend in Psychophysiology of Sport
2020
Professional lifestyle and championship period often put a great deal of pressure on athletes, who usually experience highly stressful periods during training for competitions. Recently, biomarkers of cellular aging, telomere length (TL) and telomerase activity (TA), have been considered to investigate the effects of stress and lifestyle factors. Studies in non-athletic populations have shown that stress and poor lifestyle decrease TL and TA. On the other hand, it has been shown that in general, exercise increases TL and its activity, although the underlying mechanisms remained largely unexplored. TL and TA outcomes in elite athletes remain inconclusive and mainly affected by confounding fa…
Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast.
2017
Urm1 is a unique dual-function member of the ubiquitin protein family and conserved from yeast to man. It acts both as a protein modifier in ubiquitin-like urmylation and as a sulfur donor for tRNA thiolation, which in concert with the Elongator pathway forms 5-methoxy-carbonyl-methyl-2-thio (mcm5s2) modified wobble uridines (U34) in anticodons. Using Saccharomyces cerevisiae as a model to study a relationship between these two functions, we examined whether cultivation temperature and sulfur supply previously implicated in the tRNA thiolation branch of the URM1 pathway also contribute to proper urmylation. Monitoring Urm1 conjugation, we found urmylation of the peroxiredoxin Ahp1 is suppre…
Reconstrucción de un flujo de derrubios: el desastre de Marines (Valencia) de octubre de 1957
2021
espanolEn la manana del 14 de octubre de 1957 una masa compuesta principalmente por bloques y fango procedente de la vertiente oeste de las crestas del Rodeno (Sierra Calderona) asolo la mayor parte del casco urbano de Marines (Valencia), causando 6 victimas mortales y numerosos danos materiales. A partir de la consulta de documentacion de archivo, de la revision de diversas fotografias, del examen de los depositos sedimentarios y de los testimonios de algunos supervivientes, este trabajo ensaya una reconstruccion del episodio y una interpretacion geomorfologica del movimiento de masa. Los materiales analizados han permitido elaborar una cartografia detallada de los procesos y formas del ev…
Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled rando…
2019
Abstract Background Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], HAEGARDA®, CSL Behring) twice weekly significantly reduced the frequency of acute edema attacks. Analysis of treatment effects by subgroups, onset of effect, and other exploratory analysis have not been reported. Methods This is a post hoc exploratory analysis on data from the randomized, placebo-controlled COMPACT study. 90 patients with C1-INH-HAE were randomized to 1 of 4 treatment sequences: C1-INH (SC) 40 or 60 IU/kg of body weight twice weekly for 16 weeks, pre…
Fundamentos de diseño de un entorno tecnológico para el estudio de las habilidades en resolución de problemas en primeras edades escolares
2019
En este trabajo se presentan los fundamentos de diseno de un software capaz de monitorizar y registrar datos referentes a la gestion de procesos de resolucion de problemas matematicos. El software permite una recogida sistematica de las variables del proceso de resolucion a partir de las cuales es posible obtener diferentes metricas de aprendizaje del estudiante. Al no centrar la atencion exclusivamente en el resultado final del proceso de resolucion, es posible identificar tendencias cognitivas de los estudiantes. En este manuscrito describimos las caracteristicas de este entorno tecnologico junto con la base didactica que justifica el interes de la investigacion en niveles escolares en …
La web 2.0: una ventana abierta a la interculturalidad
2012
En los últimos años se han estado desarrollando varias perspectivas y maneras de abordar la enseñanza de lenguas extranjeras desde dos puntos de vista principales que se conjugan perfectamente. Por un lado, le damos una mayor importancia a la cultura desde varias perspectivas: una cultura tan observada, tanto desde de la lengua meta como desde el punto de vista de la cultura del alumno extranjero que aprende la lengua. Hemos aprendido que la enseñanza de la lengua es indisoluble de la cultura que la envuelve. Por otro lado, combinamos este axioma de trabajo con un instrumento que se ha revelado imprescindible en la enseñanza actual, nos referimos a las nuevas tecnologías y, más concretament…
Suppression and mediation effect in psychosocial intervention: differences, similarities and examples
2013
El presente trabajo compara el efecto mediador y el supresor de una tercera variable. Ambos efectos parcelan la varianza de la variable dependiente (Y). La mediación es la reducción, tras introducir una tercera variable (Z) en el modelo, de la proporción de varianza explicada directamente por la variable independiente (X) en la variable criterio (Y) y la supresión es el incremento de la proporción de varianza explicada directamente por la independiente en la variable criterio, al incluir la tercera variable en el modelo. Se analizan las características y diferencias de cada efecto y se examina en qué situaciones se produce uno u otro. Cada situación, compuesta de tres variables correlaciona…
Synthetic approaches towards huperzine A and B
2013
Huperzine A and B are potent acetylcholinesterase inhibitors and promising against Alzheimer's disease. Completed and formal total syntheses of these medically relevant alkaloids are presented and discussed.
Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma
2010
Abstract Background Cancer genomes display characteristic patterns of chromosomal imbalances, often with diagnostic and prognostic relevance. Therefore assays for genome-wide copy number screening and simultaneous detection of copy number alterations in specific chromosomal regions are of increasing importance in the diagnostic work-up of tumors. Results We tested the performance of Multiplex Amplicon Quantification, a newly developed low-cost, closed-tube and high-throughput PCR-based technique for detection of copy number alterations in regions with prognostic relevance for neuroblastoma. Comparison with array CGH and the established Multiplex Ligation-dependent Probe Amplification method…
3 ′-5 ′ crosstalk contributes to transcriptional bursting
2019
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bay…